Results 51 to 60 of about 114,628,411 (160)

Enhanced production of withaferin - a in shoot cultures of Withania somnifera (L) Dunal [PDF]

, 2014
Withania somnifera (L) Dunal, commonly known as ashwagandha or Indian ginseng, is the source of large number of pharmacologically active withanolides. Withaferin-A (WS-3), a major withanolide of W.
Koul, Sushma, Khazir, Jabeena, Cowan, Don A., Hakeem, Khalid Rehman, Mir, Bilal Ahmad, Hakeem, Khalid R.   +5 more
core   +1 more source

Design and synthesis of new withaferin A inspired hedgehog pathway inhibitors [PDF]

, 2021
Withanolides constitute a well-known family of plant-based alkaloids characterised by widespread biological properties, including the ability of interfering with Hedgehog (Hh) signalling pathway.
Basili I., Passarella D., Mori M., Bonandi E., Calcaterra A., Botta B., Infante P., Catti F., Di Marcotullio L.   +8 more
core   +1 more source

Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells

Mediators of Inflammation, 2017
There are increasing evidences of proinflammatory cytokine involvement in cancer development. Here, we found that two cytokines, IL-6 and TNF-α, activated colorectal cancer cells to be more invasive and stem-like.
Seyung S. Chung, Yong Wu, Quincy Okobi, Debbie Adekoya, Mohammad Atefi, Orette Clarke, Pranabananda Dutta, Jaydutt V. Vadgama   +7 more
doaj   +1 more source

Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine

Molecules, 2009
Withania somnifera, commonly known as Ashwagandha, is an important medicinal plant that has been used in Ayurvedic and indigenous medicine for over 3,000 years.
Javier Palazón, Rosa M. Cusido, Mercedes Bonfill, Elisabeth Moyano, Mohammad Hossein Mirjalili   +4 more
doaj   +1 more source

Withaferin A: a potential therapeutic agent against COVID-19 infection

Journal of Ovarian Research, 2020
The outbreak and continued spread of the novel coronavirus disease 2019 (COVID-19) is a preeminent global health threat that has resulted in the infection of over 11.5 million people worldwide.
Alex R. Straughn, Sham S. Kakar
doaj   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Overexpression of the Arabidopsis thaliana squalene synthase gene in Withania coagulans hairy root cultures

Biologia Plantarum, 2011
Squalene synthase (SS) dimerizes two molecules of farnesyl diphosphate to synthesize squalene, a shared precursor in steroid and triterpenoid biosynthesis in plants.
M. H. Mirjalili, E. Moyano, M. Bonfill, R. M. Cusido, J. Palazón   +4 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Withaferin-A displays enhanced anxiolytic efficacy without tolerance in rats following sub chronic administration [PDF]

, 2013
Withaferin-A dose-dependently (10 tob40 mg/kg) displayed anxiolytic activity, as measured by an increase in open arm exploration time in the elevated plus-maze (EPM), following intraperitoneal (i.p.) administration in rats.
Ghosh, AR, Khan, ZA
core   +1 more source

Supplementary Figure from Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors

, 2023
Supplementary Figure from Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary ...
Krishna B. Singh (15111017), Shivendra V. Singh (15111026), Eun-Ryeong Hahm (15111020), Su-Hyeong Kim (15111023)   +3 more
core   +3 more sources