Results 71 to 80 of about 3,274 (173)

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, Volume 13, Issue 38, 9 July 2026.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Withaferin A attenuates ovalbumin induced airway inflammation

Frontiers in Bioscience, 2019
The molecular mechanism of how airway inflammation develops is not fully understood. Withaferin A (WA) is a natural phytochemical isolated from the plant Withania somnifera. It is a well-investigated bioactive compound that possesses a variety of health-promoting effects, including anti-inflammatory and anti-oxidative activities.
Hong Mei, Zhao, Zhi Wei, Gao, Shou Xiang, Xie, Xiang, Han, Qing Song, Sun   +4 more
openaire   +2 more sources

Structural Elucidation and Antibacterial Activity Studies of Leaf Extracts of Withania somnifera

Indonesian Journal of Chemistry, 2022
Withania somnifera (W. somnifera), a small, woody shrub in the Solanaceae family, has been studied using a phytochemical test, antibacterial activity and partial characterizations. Air-dried and powdered leaves of the plant were extracted with maceration
Amsalu Genanaw Gebeyehu, Kumlachew Zelalem Walle, Meseret ZEbeaman Birhanu, Rahel Gebeyehu   +3 more
doaj   +1 more source

Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.
ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen, Tao‐Tao Shi, Dan‐Yang Hu, Xiao‐Na Su, Jian‐Xiang Jin, Mao‐Song Chen, Hao Wang, Wei Chen   +7 more
wiley   +1 more source

Broad-spectrum antitumor properties of Withaferin A: a proteomic perspective

RSC Medicinal Chemistry, 2020
A review discussing the broad-spectrum antitumor properties of the natural steroid Withaferin A based on the binding with its true cancer protein targets: a defined stress dependent and stress independent mode of action.
Martin Dom, Wim Vanden Berghe, Xaveer Van Ostade   +2 more
openaire   +4 more sources

Evaluation of Withaferin A Content in Withania somnifera Using NMR and HPLC: A Comparative Assessment of Traditional and PCSL Extraction Methods

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
A comparative evaluation of traditional aqueous extractions and innovative pressurised cyclic solid–liquid extraction is presented for Withania somnifera leaves. Quantitative NMR, validated by HPLC, reveals a markedly enhanced preservation and recovery of withaferin A using PCSL.
Silvana Pedatella, Maria Chiara Di Meo, Daniele Naviglio, Gionata De Vico, Armando Zarrelli   +4 more
wiley   +1 more source

Genetic and Withaferin A Analysis of Iranian Natural Populations of and by RAPD and HPTLC

Natural Product Communications, 2009
For successful conservation and breeding of a medicinal species, it is important to evaluate its genetic diversity as well as its content of phytochemical compounds. The aim of the present study was to investigate the genetic variation of Iranian natural
Mohammad Hossein Mirjalili, Seyyed Mohammad Fakhr-Tabatabaei, Houshang Alizadeh, Alireza Ghassempour, Fateme Mirzajani   +4 more
doaj   +1 more source

Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice [PDF]

Nature Medicine, 2016
The increasing global prevalence of obesity and its associated disorders points to an urgent need for the development of novel and effective therapeutic strategies that induce healthy weight loss. Obesity is characterized by hyperleptinemia and central leptin resistance.
Lee, Jaemin, Feng, Xudong, Ozcan, Umut, Liu, Junli, Salazar Hernández, Mario Andrés, Mucka, Patrick, Ibi, Dorina, Choi, Jae Won   +7 more
openaire   +4 more sources

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, Volume 5, Issue 3, June 2026.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source