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Molecular insight in the multifunctional activities of Withaferin A

open access: yesBiochemical Pharmacology, 2012
Herbal medicine which involves the use of plants for their medicinal value, dates as far back as the origin of mankind and demonstrates an array of applications including cardiovascular protection and anti-cancer activities, via antioxidant, anti-inflammatory and metabolic activities.
Wim Vanden Berghe   +2 more
exaly   +5 more sources
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Cytotoxic screening and antibacterial activity of Withaferin A

Journal of Toxicology and Environmental Health, Part A, 2022
Cancer and bacterial infections are among the leading causes of death worldwide. Plant-derived bioactive compounds constitute promising alternatives for development of new therapeutics. This study aimed at evaluating the biological activity of Withaferin A using 6 tumor cell lines: A549 (lung cancer), U87MG (glioblastoma), SH-SY5Y (neuroblastoma), B16 ...
Altevir, Rossato Viana   +9 more
openaire   +2 more sources

Microbiological and chemical dehydrogenation of withaferin A

Folia Microbiologica, 1987
Arthrobacter simplex dehydrogenated withaferin A to 4-dehydrowithaferin A but it was not able to dehydrogenate this substrate in position 27. 27-Dehydrowithaferin A was prepared chemically using pyridinium chlorochromate. Whereas 4-dehydrowithaferin A surpassed in its effect on leukemic (388 cells the original compound and all its derivates synthesized
J, Fuska   +3 more
openaire   +2 more sources

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