Evaluating anticancer properties of Withaferin A—a potent phytochemical
Frontiers in Pharmacology, 2022 Withaferin A is a C28 steroidal lactone derived from the plant Withania somnifera, commonly known as Ashwagandha. Withaferin A has received great attention for its anticancer properties noted in cancer cells of various origins.
Maushma Atteeq
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Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC
Frontiers in Oncology, 2021 Withaferin A, a steroidal lactone derived from the Withania somnifera plant has been known for its anti-cancerous effects on various types of cancer cells.
Varsha D. Shiragannavar +4 more
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Cytotoxic Potential Evaluation of Innovative Pressurised Cyclic Solid–Liquid Extracts from Withania somnifera [PDF]
PlantsEthnopharmacological relevance. Withania somnifera (L.) Dunal, widely used in traditional medical systems such as Ayurveda, Unani, and Middle Eastern folk medicine, is valued for its adaptogenic, anti-inflammatory, neuroprotective, antimicrobial, and ...
Rosanna Culurciello +9 more
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Formulation and In Vitro Characterisation of Withaferin A-Loaded Liposomal Gels for the Topical Management of Chronic Inflammatory Skin Conditions [PDF]
British Journal of Biomedical ScienceChronic inflammatory skin conditions such as psoriasis, eczema, and acne are driven by sustained inflammation, oxidative stress, and impaired tissue repair.
Mandeep Kaur Marwah +6 more
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Estimation of Withaferin-A by HPLC and standardization of the Ashwagandhadi lehyam formulation
Heliyon, 2021 Standardization is an important measurement for ensuring the quality control of herbal drugs. It has become essential to develop reliable, specific and sensitive quality control methods.
Ajay Kumar Meena +5 more
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Withaferin A Associated Differential Regulation of Inflammatory Cytokines [PDF]
Frontiers in Immunology, 2018 A role of inflammation-associated cytokines/chemokines has been implicated in a wide variety of human diseases. Here, we investigated the regulation of inflammatory cytokines released by monocyte-derived THP-1 cells following treatment with the dietary ...
Seema Dubey +5 more
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Tackling Chronic Inflammation with Withanolide Phytochemicals—A Withaferin A Perspective [PDF]
Antioxidants, 2020 Chronic inflammatory diseases are considered to be one of the biggest threats to human health. Most prescribed pharmaceutical drugs aiming to treat these diseases are characterized by side-effects and negatively affect therapy adherence.
Emilie Logie, Wim Vanden Berghe
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Overview of Ayurveda and Ashwagandha: Bioactive Phytochemicals and Potential Applications to Gliomas [PDF]
MoleculesAyurveda is the traditional medical system of India and has been in use for more than 5000 years. The focus of Ayurveda is to maintain harmony and balance of the three Doshas (Vata, Pitta, Kapha), or life forces, that govern the physiology and health of ...
Herbert B. Newton
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Network pharmacology and in-silico studies for molecular mechanisms of analgesic, anti-inflammatory and anti-arthritic effects of Withania somnifera (L.) Dunal phytoconstituents [PDF]
Journal of Ayurveda and Integrative MedicineBackground: Withania somnifera (L.) Dunal, commonly known as ashwagandha, is an Ayurvedic herb belonging to the family Solanaceae. Objectives: This study aims to explore the analgesic, anti-inflammatory and anti-arthritic potential of phytoconstituents ...
Mukul S. Tambe +4 more
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Computational discovery of natural inhibitors targeting enterovirus D68 3C protease using molecular docking pharmacokinetics and dynamics simulations [PDF]
Scientific ReportsEnterovirus D68 (EV-D68) is a significant global health threat, responsible for severe respiratory and neurological complications, with no FDA-approved antiviral treatments currently available.
Mansoor Alsahag
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