Results 41 to 50 of about 81,875,801 (209)

Estimating the production of withaferin A and withanolide A in Withania somnifera (L.) dunal using aquaponics for sustainable development in hill agriculture

Frontiers in Plant Science, 2023
IntroductionHumanity is suffering from huge and severe difficulties, including changes in climate, soil degradation, scarcity of water and the security of food and medicines, among others.
Manali Singh, Shivani Bhutani, Nisha Dinkar, Anita Mishra, Kahkashan Perveen, Alanoud T. Alfagham, Mehrun Nisha Khanam, Santosh Chandra Bhatt, Deep Chandra Suyal   +8 more
doaj   +1 more source

Evaluation of the Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects of Withaferin A (WA) against Lipopolysaccharide (LPS)-Induced Inflammation in Immune Cells Derived from BALB/c Mice

Pharmaceutics, 2022
(1) Background: Inflammation is one of the primary responses of the immune system and plays a key role in the pathophysiology of various diseases. Recent reports suggest that various phytochemicals exhibit promising anti-inflammatory and immunomodulation
Abdullah M. Alnuqaydan, Abdulmajeed Almutary, Gh Rasool Bhat, Tanveer Ahmad Mir, Shadil Ibrahim Wani, Mohd Younis Rather, Shabir Ahmad Mir, Bader Alshehri, Sulaiman Alnasser, Faten M. Ali Zainy, Bilal Rah   +10 more
doaj   +1 more source

Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights [PDF]

Drug Metabolism and Disposition, 2022
Withaferin A (WA) is a natural steroidal compound used in Ayurvedic medicine in India and elsewhere. Although WA was used as an anticancer reagent for decades, its role in the treatment of liver diseases has only recently been experimentally explored.
Yangliu, Xia, Mingrui, Yan, Ping, Wang, Keisuke, Hamada, Nana, Yan, Haiping, Hao, Frank J, Gonzalez, Tingting, Yan   +7 more
openaire   +2 more sources

Withaferin A Analogs That Target the AAA+ Chaperone p97 [PDF]

ACS Chemical Biology, 2015
Understanding the mode of action (MOA) of many natural products can be puzzling with mechanistic clues that seem to lack a common thread. One such puzzle lies in the evaluation of the antitumor properties of the natural product withaferin A (WFA). A variety of seemingly unrelated pathways have been identified to explain its activity, suggesting a lack ...
Shasha, Tao, Joseph, Tillotson, E M Kithsiri, Wijeratne, Ya-Ming, Xu, MinJin, Kang, Tongde, Wu, Eric C, Lau, Celestina, Mesa, Damian J, Mason, Robert V, Brown, James J La, Clair, A A Leslie, Gunatilaka, Donna D, Zhang, Eli, Chapman   +13 more
openaire   +2 more sources

Pharmacokinetics and bioequivalence of Withania somnifera (Ashwagandha) extracts – A double blind, crossover study in healthy adults

Heliyon, 2023
Introduction: Withania somnifera (WS) or ashwagandha is an adaptogenic plant used extensively in traditional medicines and as a food supplement. Despite a long history of use and numerous clinical trials, the human pharmacokinetics of withanolides, the ...
Se-Kwon Kim, Jayachandran Venkatesan, Priyank Rathi, Benny Antony   +3 more
doaj   +1 more source

Withaferin A recovery in sWRE.

, 2013
sWRE powder was dissolved in different solvents and the concentration (A) and recovery rate (B) of Withaferin A in sWRE was measured by HPLC. The stability of Withaferin A in sWRE (90% EtOH stock solution) over time is shown in a bar graph with the ...
Doris R. Powell (457630), Songli Xu (457629), Anapatricia Garcia (457628), Paula M. Vertino (457631), Zhen Yang (107412), Adam I. Marcus (457633), Shivendra Singh (457632)   +6 more
core   +1 more source

Design and synthesis of new withaferin A inspired hedgehog pathway inhibitors [PDF]

, 2021
Withanolides constitute a well-known family of plant-based alkaloids characterised by widespread biological properties, including the ability of interfering with Hedgehog (Hh) signalling pathway.
Basili I., Passarella D., Mori M., Bonandi E., Calcaterra A., Botta B., Infante P., Catti F., Di Marcotullio L.   +8 more
core   +1 more source

Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells

Mediators of Inflammation, 2017
There are increasing evidences of proinflammatory cytokine involvement in cancer development. Here, we found that two cytokines, IL-6 and TNF-α, activated colorectal cancer cells to be more invasive and stem-like.
Seyung S. Chung, Yong Wu, Quincy Okobi, Debbie Adekoya, Mohammad Atefi, Orette Clarke, Pranabananda Dutta, Jaydutt V. Vadgama   +7 more
doaj   +1 more source

Withaferin A: a potential therapeutic agent against COVID-19 infection

Journal of Ovarian Research, 2020
The outbreak and continued spread of the novel coronavirus disease 2019 (COVID-19) is a preeminent global health threat that has resulted in the infection of over 11.5 million people worldwide.
Alex R. Straughn, Sham S. Kakar
doaj   +1 more source

Supplementary Figure from Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors

, 2023
Supplementary Figure from Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary ...
Krishna B. Singh (15111017), Shivendra V. Singh (15111026), Eun-Ryeong Hahm (15111020), Su-Hyeong Kim (15111023)   +3 more
core   +3 more sources