Results 31 to 40 of about 81,875,801 (209)
Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
Biomedicines, 2020 Withaferin A (WA), a manifold studied, C28-steroidal lactone withanolide found in Withania somnifera. Given its unique beneficial effects, it has gathered attention in the era of modern science.
Tapan Behl +7 more
doaj +1 more source
Withaferin A: From Ancient Remedy to Potential Drug Candidate [PDF]
Molecules, 2021 Withaferin A (WA) is a pivotal withanolide that has conquered a conspicuous place in research, owning to its multidimensional biological properties. It is an abundant constituent in Withania somnifera Dunal. (Ashwagandha, WS) that is one of the prehistoric pivotal remedies in Ayurveda.
Tahira Sultana +6 more
openaire +4 more sources
Withaferin A downregulates COX-2/NF-κB signaling and modulates MMP-2/9 in experimental endometriosis
, 2022 Purpose: To study the effect of withaferin A on an experimentally-induced endometriosis (EM) model. Methods: Female Sprague-Dawley rats were induced EM by implantation of autologous endometrium.
Huimin, Wang +5 more
core +2 more sources
Withaferin A Improves Nonalcoholic Steatohepatitis in Mice [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2019 Nonalcoholic steatohepatitis (NASH) is the progressive stage of nonalcoholic fatty liver disease that highly increases the risk of cirrhosis and liver cancer, and there are few therapeutic options available in the clinic. Withaferin A (WA), extracted from the ayurvedic medicine Withania somnifera, has a wide range of pharmacological activities; however,
Daxesh P, Patel +6 more
openaire +2 more sources
Vimentin as a potential therapeutic target in sorafenib resistant HepG2, a HCC model cell line [PDF]
Clinical and Molecular Hepatology, 2020 Background/Aims Hepatocellular carcinoma (HCC) is the most common liver cancer with high mortality rate in patients suffering from liver diseases. The drug of choice used in advanced-stage of HCC is sorafenib.
Ankita Makol +5 more
doaj +1 more source
Evaluation of the geroprotective effects of withaferin A in Drosophila melanogaster
Aging, 2021 Withanolides are a class of compounds usually found in plant extracts which are an attractive geroprotective drug design starting point. We evaluated the geroprotective properties of Withaferin A (WA) in vivo using the Drosophila model. Flies were supplemented by nutrient medium with WA (at a concentration of 1, 10, or 100 μM dissolved in ethanol) for ...
Koval, Liubov +4 more
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Frontiers in Pharmacology, 2018 Pulmonary fibrosis (PF) is chronic lung disease with only two FDA approved clinically available drugs, with limited safety profile. Inadequate therapy motivated us to explore the effect of vimentin inhibitor Withaferin A, as an anti-fibrotic agent ...
Swarna Bale +3 more
doaj +1 more source
, 2022 Withaferin A, a natural steroidal lactone found in the extracts of Withania somnifera, is used extensively in traditional medicine and part of an ancient remedy in ayurvedic medicine.
Winssinger, Nicolas +2 more
core +1 more source
Withaferin A for COVID-19: a Network Pharmacology Approach
Applied Biochemistry and Biotechnology, 2023 COVID-19 has become a global challenge as there are very few treatment options available. This has proved to impact several physiological implications like immunological injury, myocardial infarction, micro-thrombus formation, neurological complications and multi-organ dysfunction. A combination therapy or a systems pharmacology approach can be adopted
Ashasmita S. Mishra +3 more
openaire +2 more sources
Benefits of Withania somnifera (Ashwagandha) supplementation in obesity
Journal of Education, Health and Sport, 2023 Introduction and purpose: Ashwagandha (fam. Solanaceae) also known as Withania somnifera, is an herb commonly used in traditional Ayurvedic medicine. It is sometimes called Indian ginseng or winter cherry and it is used for its extensive health benefits
Alicja Nowak +8 more
doaj +1 more source