Results 71 to 80 of about 1,289,348 (247)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

The Effects of Aqueous Extracts of Purtulaca oleracea on Withdrawal Syndrome in Mice

Journal of Medicinal Plants, 2009
Background: Purtulaca pleracea (PO) overgrows in the different parts of Iran. In previous studies, the extract of P.O showed antinociceptive, anxiolytic and anti inflammation effects in Mice and rats.
H Miladi-Gorgi, AA Vafaei, AA Taherian, T Vaezi   +3 more
doaj  

Clinical management of gamma-hydroxybutyrate (GHB) withdrawal delirium with CIWA-Ar protocol

Journal of the Formosan Medical Association, 2018
Gamma-hydroxybutyrate (GHB) is a synthetic drug used mainly for recreational purpose. Although the prevalence of GHB abuse is low in Taiwan, GHB has become increasingly popular in certain subpopulations such as clubbers and men who have sex with men (MSM)
Po-Chiao Liao, Hu-Ming Chang, Lian-Yu Chen   +2 more
doaj   +1 more source

Benzodiazepine Withdrawal Syndrome Seizures

Pharmacopsychiatry, 1995
In this study, we present five cases of seizures following withdrawal of flunitrazepam, lorazepam, or triazolam, representing 3% of a sample consisting of 153 patients dependent on benzodiazepines. Both abrupt cessation of benzodiazepine intake and high-dose use seem to be critical for the appearance of seizures. Pharmacological features, such as short
H, Martínez-Cano, A, Vela-Bueno, M, de Iceta, R, Pomalima, I, Martínez-Gras   +4 more
openaire   +2 more sources

Propranolol withdrawal syndrome. [PDF]

Introduction. Propranolol, a non-selective beta-blocker widely used for the treatment of various cardiovascular diseases. However, its abrupt discontinuation can lead to withdrawal syndrome.This syndrome manifests as increased adrenergic sensitivity ...
Žemaitis, Augustinas,, Podčašinskytė, Kotryna,   +1 more
core   +1 more source

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

Advanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian, Yalan Wan, Chen Chen, Xiaoyu Zheng, Wenjing Du, Junhan Yang, Zhihao Quan, Biyu Yang, Jiaxi Yu, Jie Zheng, Zhaoxia Wang, Jianwen Deng, Qiang Guo   +12 more
wiley   +1 more source

Effect of Zhumeria majdae Rech. f. & Wendelbo Aerial Parts Extracts and Fractions on Morphine Withdrawal Syndrome in Mice

Journal of Medicinal Plants, 2007
Background: Zhumeria majdae showed antinociceptive and anti-inflammatory activity. The antinociceptive effect was inhibited by naloxone in hot-plate test. Objective: As Z.
H Hosseinzadeh, M Ramezani, M Ghorbani
doaj  

Status dystonicus resembling the intrathecal baclofen withdrawal syndrome: a case report and review of the literature

Journal of Medical Case Reports, 2010
Introduction Status dystonicus is a rare but life-threatening disorder characterized by increasingly frequent and severe episodes of generalized dystonia that may occur in patients with primary or secondary dystonia.
Muirhead William, Jalloh Ibrahim, Vloeberghs Michael   +2 more
doaj   +1 more source