Results 221 to 230 of about 423,254 (279)

ISX9 activates the Wnt/β-catenin signaling pathway and exerts neuroprotective effects in Alzheimer's disease. [PDF]

Alzheimers Res Ther
Xiao J, Liu Y, Peng M, Ma J, Lei S, Chen Y, Liu S, Zhao X, Lu D, Sun Q.   +9 more
europepmc   +1 more source

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy

Advanced Science, EarlyView.
CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng, Simei Zhao, Zheng Wei, Wenwen Wang, Feiquan Ying, Lin Huang, Mengna Zhu, Mengqing Chen, Qiang Yang, Si Sun, Dawei Jiang, Lingling Gao, Jing Cai   +12 more
wiley   +1 more source

The Role of Fibroblast-Epithelial Cross-Talk on the Distribution of Distinct Fibroblast Phenotypes in the Intestinal Crypt. [PDF]

Bull Math Biol
Atkinson G, Leedham S, Byrne HM.
europepmc   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

FNDC1 Competitively Binds Gβ2 to Suppress the β-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy. [PDF]

FASEB J
Gao W, Chen H, Lin F, Liu J, Huang T, Wang H, Weng X, Wang X, Lin X, Jiang T.   +9 more
europepmc   +1 more source

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

The role of deubiquitinase USP33 in colorectal cancer tumorigenesis and its potential as a therapeutic target predictor. [PDF]

Discov Oncol
Dai Y, Luo X, Wu H, Luo Y, Deng Z, Wu J, Zhang L, Yan J.   +7 more
europepmc   +1 more source

Approaching Scarless Wound Healing: From Passive Anti‐Fibrotic to Proactive and Programmable Pro‐Regenerative Strategies

Advanced Science, EarlyView.
This review outlines the wound healing process and factors influencing scar formation, explores how certain animals and human fetuses achieve scarless skin or tissue regeneration, and details tissue engineering material strategies employed in scarless wound dressings.
Meimei Fu, Zhuoyi Huang, Jintao Li, Yue Li, Zhou Fang, Yiwen Jiang, Keke Wu, Jinshan Guo   +7 more
wiley   +1 more source

Anti-resonance in developmental signaling regulates cell fate decisions. [PDF]

Elife
Rosen SJ, Witteveen O, Baxter N, Lach RS, Hopkins E, Bauer M, Wilson MZ.   +6 more
europepmc   +1 more source