Results 221 to 230 of about 315,126 (245)
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Caught up in a Wnt storm: Wnt signaling in cancer
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2003The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in various differentiation events during embryonic development and leads to tumor formation when aberrantly activated. Molecular studies have pinpointed activating mutations of the Wnt signaling pathway as the cause of approximately 90% of colorectal cancer (CRC), and
Johan H. van Es +2 more
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Trends in Cell Biology, 2000
Wnts regulate cell differentiation through receptors of the Frizzled family, involving translocation of β-catenin to the nucleus, where it binds to TCF/LEF transcription factors that regulate Wnt target genes. Ross et al.1xInhibition of adipogenesis by Wnt signaling. Ross, S.E. et al. Science.
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Wnts regulate cell differentiation through receptors of the Frizzled family, involving translocation of β-catenin to the nucleus, where it binds to TCF/LEF transcription factors that regulate Wnt target genes. Ross et al.1xInhibition of adipogenesis by Wnt signaling. Ross, S.E. et al. Science.
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Sailing with the Wnt: Charting the Wnt processing and secretion route
Experimental Cell Research, 2009Wnt proteins are members of a highly conserved family of signalling molecules that play a central role in development and disease. During the past years, the different signalling pathways that are triggered by Wnt proteins have been studied in detail, but it is still largely unknown how a functional Wnt protein is produced and secreted.
Magdalena J. Lorenowicz +1 more
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Wnt signaling in the vasculature
Angiogenesis, 2002The Wnt signaling pathway regulates normal development as well as a variety of pathologies. Studies of the Wnt pathway have focused largely on very early development and on tumorigenesis. Recent observations point to a role for Wnt signaling in vessel development and pathology. Although not yet investigated systematically, several Wnt ligands have been
Anne M. Goodwin, Patricia A. D'Amore
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Current Opinion in Immunology, 2003
Wnt proteins are secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis in many different tissues and species. Wnt signaling is required for normal thymocyte development, most dramatically at the pro-T-cell stage, although recent reports also indicate a role for Wnt proteins in later stages of thymocyte ...
Hans Clevers, Frank J. T. Staal
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Wnt proteins are secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis in many different tissues and species. Wnt signaling is required for normal thymocyte development, most dramatically at the pro-T-cell stage, although recent reports also indicate a role for Wnt proteins in later stages of thymocyte ...
Hans Clevers, Frank J. T. Staal
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Modulating Wnt signaling at the root: Porcupine and Wnt acylation
Pharmacology & Therapeutics, 2019Communication between cells occurs through secreted molecules, among which Wnt ligands play a critical role in balancing cell proliferation, differentiation and cellular homeostasis. The action of Wnt signaling can be modulated at several levels, including posttranslational modification of the Wnt ligands, whose acylation is critical for biological ...
Nibaldo C. Inestrosa +4 more
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Wnts, Signaling and Sulfates [PDF]
Science's STKE, 2001 Questions remain about the signaling pathways that control pattern formation during development. Blair describes how sulfated glycosaminoglycans affect several developmentally important signaling pathways, including Wnt-Wingless, Fibroblast growth factor, Hedgehog, and Bone morphogenetic protein-4 signaling.
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Anatomy and Embryology, 2005
The neural crest is a multipotent tissue that originates between the neural epithelium and non-neural ectoderm, which can develop into numerous cell types, including neurons, glia, pigment cells, smooth muscle, cartilage and bone. Work in a variety of animal models has shown that a number of signalling factors are necessary for the induction ...
Corina Schmidt +2 more
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The neural crest is a multipotent tissue that originates between the neural epithelium and non-neural ectoderm, which can develop into numerous cell types, including neurons, glia, pigment cells, smooth muscle, cartilage and bone. Work in a variety of animal models has shown that a number of signalling factors are necessary for the induction ...
Corina Schmidt +2 more
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Trends in Genetics, 2004
Recent research on the WNT signaling pathway warrants a reassessment of the basic mechanism that transmits signal from the membrane-bound receptor to the nucleus. This article incorporates these findings into a revised model for pathway activation. We propose that the control of Axin stability, rather than the control of ZW3 phosphorylation of the ...
Nicholas S. Tolwinski, Eric Wieschaus
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Recent research on the WNT signaling pathway warrants a reassessment of the basic mechanism that transmits signal from the membrane-bound receptor to the nucleus. This article incorporates these findings into a revised model for pathway activation. We propose that the control of Axin stability, rather than the control of ZW3 phosphorylation of the ...
Nicholas S. Tolwinski, Eric Wieschaus
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A Wnt-er Wonderland—The complexity of Wnt signaling in melanoma
Cancer and Metastasis Reviews, 2005Wnt signaling is a complex process that requires the interplay of several different proteins. In addition to a large cohort of Wnt ligands, and frizzled receptors, some Wnt pathways also require the presence of co-receptors. Wnt ligands may activate one of three pathways, the canonical pathway, involving beta -catenin, the planar cell polarity pathway ...
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