Results 231 to 240 of about 459,861 (330)

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway. [PDF]

Int J Mol Med
Zhao Q, Gao S, Du Q, Liu Y.
europepmc   +1 more source

Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism [PDF]

, 2000
Tannishtha Reya, Mary O’Riordan, Ross M. Okamura, Erik Devaney, Karl Willert, Roel Nusse, Rudolf Grosschedl   +6 more
openalex   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

ZNF710 regulates the proliferation, migration, apoptosis, and cell cycle progression of gastric cancer cells through the Wnt/β-catenin pathway. [PDF]

Am J Cancer Res
Zhou R, Zhou J, Cai J, Wen J, Wang F, Ma D, Luo Q, Yalikun A, Han J, Zhou X, Yu Y, Li Q, Wen Y.   +12 more
europepmc   +1 more source

Wnt/β-Catenin Signaling: a Promising New Target for Fibrosis Diseases

, 2012
Yulong Guo, Lianbo Xiao, Lunquan Sun, F. Liu   +3 more
openalex   +1 more source

Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind [PDF]

, 2019
Joanna Bem, Nikola Brożko, Chaitali Chakraborty, Marcin Andrzej Lipiec, Kamil Koziński, Andrzej Nagalski, Łukasz M. Szewczyk, M. Wisniewska   +7 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Regulation of glypican 6-mediated Wnt activation maintains TDP-43 nuclear localization in neurons. [PDF]

Sci Rep
Zhang N, Sockanathan S.
europepmc   +1 more source

Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice [PDF]

, 2009
Hong Zhou, Wendy Mak, Robert Kalak, Janine Street, Colette Fong-Yee, Yu Zheng, Colin R. Dunstan, Markus J. Seibel   +7 more
openalex   +1 more source