Results 211 to 220 of about 206,629 (264)

E3 ligase MKRN2 destabilizes PPP2CA proteins to inactivate canonical Wnt pathway and mitigates tumorigenesis of clear cell renal cell carcinoma. [PDF]

Int J Biol Sci
Yu T, Li W, Meng X, Yuan H, Ruan H, Xiao W, Zhang X.   +6 more
europepmc   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

Rhaponitin Reverses Cisplatin Resistance and Impairs Cancer Stemness Through HIF-1α/MCT4/Wnt Pathway in Tongue Squamous Cell Carcinoma. [PDF]

Kaohsiung J Med Sci
Wu Y, Wan XW, Jiang L, Wang W, Zhu JJ, Shao YS.   +5 more
europepmc   +1 more source

NID1 promotes laryngeal cancer stemness via activating WNT pathway. [PDF]

Biol Direct
Liu W, Wu J, Lai Y, Zhang S, Yang A, Li Y, Chen C, Lu Z.   +7 more
europepmc   +1 more source

Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb. [PDF]

Sci Rep
Varella FJ, Xavier FAC, Zanirati G, Gonçalves JIB, Previato TTR, Pazzin DB, Pereira-Neto NG, Paglioli E, Martins WA, Palmini A, Dos Santos AS, Abreu JG, Leichtweis KS, Machado DC, Da Costa JC, Marinowic DR.   +15 more
europepmc   +1 more source

Conversational AI agent for precision oncology: AI-HOPE-WNT integrates clinical and genomic data to investigate WNT pathway dysregulation in colorectal cancer. [PDF]

Front Artif Intell
Yang EW, Waldrup B, Velazquez-Villarreal E.   +2 more
europepmc   +1 more source

Unraveling the Role of the Wnt Pathway in Hepatocellular Carcinoma: From Molecular Mechanisms to Therapeutic Implications. [PDF]

J Clin Transl Hepatol
Liang Z, Li S, Wang Z, Zhou J, Huang Z, Li J, Bao H, Yam JWP, Xu Y.   +8 more
europepmc   +1 more source

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The Wnt Pathway

Annual Review of Biochemistry, 2022
The Wnt pathway is central to a host of developmental and disease-related processes. The remarkable conservation of this intercellular signaling cascade throughout metazoan lineages indicates that it coevolved with multicellularity to regulate the generation and spatial arrangement of distinct cell types.
Rim, Ellen Youngsoo, Clevers, Hans, Nusse, Roel   +2 more
openaire   +1 more source

Drosophila Wnt/Fz Pathways

Science's STKE, 2005
Wnts [also known as Wingless (Wg)] are a family of conserved signaling molecules involved in a plethora of fundamental developmental and cell biological processes, such as cell proliferation, differentiation, and cell polarity. Dysregulation of the pathway can be detrimental, because several components are tumorigenic when mutated and are ...
Ramanuj, DasGupta, Michael, Boutros, Norbert, Perrimon   +2 more
openaire   +2 more sources