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Wnt Signaling Pathway in Schizophrenia
CNS & Neurological Disorders - Drug Targets, 2014The Wnt signaling pathway is one of the crucial signaling pathways that regulate many aspects of central nervous system. In this review, we tempt to depict an overall picture of the Wnt signaling with its multitude of roles in schizophrenia. If the Wnt signaling pathway plays a crucial role in the pathogenesis of schizophrenia as we suggest, a better ...
Yanmin, Peng, Yifeng, Xu, Donghong, Cui
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Wnt signalling: pathway or network?
Current Opinion in Genetics & Development, 1999Members of the Wnt family of secreted glycoproteins participate in many signalling events during development. Recent findings suggest that Wnt signals can sometimes play a permissive role during cell-fate assignment. Wnt proteins have been shown to interact with a number of extracellular and cell-surface proteins, whereas many intracellular components ...
Arias, Alfonso Martinez +2 more
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Frontiers in Bioscience, 2007
Breast cancer is one of the most debilitating human carcinomas with second highest mortality rate after lung cancer in women. Recent advancement in genetic and biochemical analyses has deciphered the molecular pathways involved in breast cancer development. Wnt signal has long been established to play a critical role in normal development as well as in
Sonia, Mohinta +3 more
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Breast cancer is one of the most debilitating human carcinomas with second highest mortality rate after lung cancer in women. Recent advancement in genetic and biochemical analyses has deciphered the molecular pathways involved in breast cancer development. Wnt signal has long been established to play a critical role in normal development as well as in
Sonia, Mohinta +3 more
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Science Signaling, 2015
Wnt signals through G proteins to activate the transcriptional coregulators YAP and TAZ.
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Wnt signals through G proteins to activate the transcriptional coregulators YAP and TAZ.
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2008
Abstract The Wnt (wingless) signaling pathway is an important signal transduction pathway that is well conserved across animal phyla. Wnts are a large family of secreted signaling molecules known to play important and diverse roles in developmental processes such as cell fate speci7cation, cell migration, and cell proliferation ...
Lorna S Kategaya +2 more
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Abstract The Wnt (wingless) signaling pathway is an important signal transduction pathway that is well conserved across animal phyla. Wnts are a large family of secreted signaling molecules known to play important and diverse roles in developmental processes such as cell fate speci7cation, cell migration, and cell proliferation ...
Lorna S Kategaya +2 more
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Science's STKE, 2001
A canonical Wnt pathway has been established in which Wnt proteins signal though homologues of b-catenin, which regulates activity of Tcf transcription factors (see the Wnt/beta-catenin Connections Map by Moon ). Herman analyzed Wnt signaling in C elegans (see the C. elegans
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A canonical Wnt pathway has been established in which Wnt proteins signal though homologues of b-catenin, which regulates activity of Tcf transcription factors (see the Wnt/beta-catenin Connections Map by Moon ). Herman analyzed Wnt signaling in C elegans (see the C. elegans
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Science, 2004
STKE Frizzled proteins act as receptors for Wnts, secreted proteins that play a critical role in animal development. In Caenorhabditis elegans vulval development, the anterior-posterior orientation of cells of the P7.p lineage is disrupted by mutation of lin-17 (which encodes a Frizzled protein)
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STKE Frizzled proteins act as receptors for Wnts, secreted proteins that play a critical role in animal development. In Caenorhabditis elegans vulval development, the anterior-posterior orientation of cells of the P7.p lineage is disrupted by mutation of lin-17 (which encodes a Frizzled protein)
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Clinical calcium, 2013
Wnts transduce signals through Wnt/β-catenin pathway (canonical pathway) , in which β-catenin stimulates transcription of target genes, as well as several kinds of non-β-catenin Wnt pathways (alternative pathways) . Wnt/β-catenin pathway is essential for cell proliferation and survival, and its activity is strictly regulated by several antagonists ...
Yuka, Kinoshita, Seiji, Fukumoto
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Wnts transduce signals through Wnt/β-catenin pathway (canonical pathway) , in which β-catenin stimulates transcription of target genes, as well as several kinds of non-β-catenin Wnt pathways (alternative pathways) . Wnt/β-catenin pathway is essential for cell proliferation and survival, and its activity is strictly regulated by several antagonists ...
Yuka, Kinoshita, Seiji, Fukumoto
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Wnt pathway modulators in cancer therapeutics: An update on completed and ongoing clinical trials
International Journal of Cancer, 2022Anitha Shenoy
exaly