Results 31 to 40 of about 317,971 (305)
Evolution of the Wnt Pathways [PDF]
, 2008 Wnt proteins mediate the transduction of at least three major signaling pathways that play central roles in many early and late developmental decisions. They control diverse cellular behaviors, such as cell fate decisions, proliferation, and migration, and are involved in many important embryological events, including axis specification, gastrulation ...
Croce, Jenifer, Mcclay, David
openaire +3 more sources
Model Reduction on the Wnt Pathway Leads to Biological Adaptation [PDF]
, 2001 Complex systems are an unavoidable problem in the field of biology. One of the ways that scientists have tried to overcome this problem is by building mathematical models—manageable representations designed to look at specific physical phenomena. The Wnt
Filej, B. +4 more
core +2 more sources
Osteocytes and mechanical loading: The Wnt connection [PDF]
, 2019 Bone adapts to the mechanical forces that it experiences. Orthodontic tooth movement harnesses the cell‐ and tissue‐level properties of mechanotransduction to achieve alignment and reorganization of the dentition.
Ahn Y +21 more
core +1 more source
From individual Wnt pathways towards a Wnt signalling network [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2008 Wnt proteins play important roles during vertebrate and invertebrate development. They obviously have the ability to activate different intracellular signalling pathways. Based on the characteristic intracellular mediators used, these are commonly described as the Wnt/β-catenin, the Wnt/calcium and the Wnt/Jun N-terminal kinase pathways (also called ...
Hans A, Kestler, Michael, Kühl
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Role of the Wnt signaling molecules in the tooth
Japanese Dental Science Review, 2016 Wnt signaling plays a central role in many processes during embryonic development and adult homeostasis. At least 19 types of Wnt ligands, receptors, transducers, transcription factors, and antagonists have been identified in mammals.
Masato Tamura, PhD, DDS +1 more
doaj +1 more source
The C. Elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway [PDF]
, 2007 Inhibitors of Wnt signaling promote normal development and prevent cancer by restraining when and where the Wnt pathway is activated. ROR proteins, a class of Wnt-binding receptor tyrosine kinases, inhibit Wnt signaling by an unknown mechanism.
Green, Jennifer L. +2 more
core +2 more sources
Interaction of viral oncogenic proteins with the Wnt signaling pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2018 It is estimated that up to 20% of all types of human cancers worldwide are attributed to viruses. The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation.
Sayyad Khanizadeh +4 more
doaj +1 more source
Premise and peril of Wnt signaling activation through GSK-3β inhibition
iScience, 2022 Summary: Wnt signaling pathways have been extensively studied in the context of several diseases, including cancer, coronary artery disease, and age-related disorders.
Samuel M. Law, Jie J. Zheng
doaj +1 more source
Activation of the Wnt Pathway by Mycobacterium tuberculosis: A Wnt–Wnt Situation [PDF]
Frontiers in Immunology, 2017 Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogenic Gram-positive bacterium, is the cause of Tuberculosis, a major worldwide human infectious disease. The innate immune system is the first host defense against M. tuberculosis. The recognition of this pathogen is mediated by several classes of pattern recognition receptors (PRRs ...
Tomás Villaseñor +5 more
openaire +2 more sources
Wnt signalling in intestinal stem cells: lessons from mice and flies [PDF]
, 2018 Adult stem cells play critical roles in the basal maintenance of tissue integrity, also known as homeostasis, and in tissue regeneration following damage. The highly conserved Wnt signalling pathway is a key regulator of stem cell fate.
Carroll, Lynsey +2 more
core +2 more sources