Results 251 to 260 of about 176,136 (293)

Exploring the origins of a signaling pathway. [PDF]

Elife
Santhanam B.
europepmc   +1 more source

Application of STUPPIT to identify novel intermediary proteins between SMAD4 and β-catenin, central hubs of BMP and Wnt pathway.

Lin Xie (136792), Lijuan Gao (5093777), Weihong Fu (8430690), Gangyun Wu (22676687), Hua Li (46469), Wenxiu Ning (18239607)   +5 more
openalex   +1 more source

Creating Cell‐Based Hybrid Noodles for Sustainable and Nutrient‐Balanced Diets via a Serum‐Free and Animal‐Free 3D Co‐Differentiation System

Advanced Science, EarlyView.
This study develops a 3D co‐culture and co‐differentiation system for porcine muscle stem cells (pMuSCs) and mesenchymal stem cells (pMSCs) on edible starch‐based scaffolds. The system simultaneously generates myotubes and adipocytes without using serum or chemical inducers.
Xin Guan, Luyi Wang, Wanqiang Sun, Yiwei Feng, Dandan Wang, Haohao Tang, Zhenwu Ma, Guocheng Du, Jian Chen, Jingwen Zhou   +9 more
wiley   +1 more source

Sesamin alleviates androgenetic alopecia by targeting the AR MAPK Wnt axis. [PDF]

Sci Rep
Li Y, Chen J, Xi R, Tang Q, Gao T, Qian Y, Huang Z, Ding B, Cao Y.   +8 more
europepmc   +1 more source

Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact

Advanced Science, EarlyView.
Multi‐omics profiling of stroke patients exposes systemic molecular fingerprints of immune activation, oxidative stress and metabolic collapse. Complement and coagulation cascade, and cholesterol metabolism emerge as shared functional hallmarks of plasma migrasomes in stroke patients and migrasomes isolated from experimental stroke mice.
Huifen Zhou, Yingying Zhang, Peng Zhou, Haofang Wan, Lingling Li, Bin Xu, Yuping Wan, Yingming Song, Yi Kang, Hongbo Zhang, Min Shi, Qun Hou, Jiehong Yang, Chen Ding, Wei Fu, Buchang Zhao, Haitong Wan   +16 more
wiley   +1 more source

Targeted protein degradation of Wnt/β-catenin signaling pathway: an effective strategy for cancer therapy. [PDF]

J Transl Med
Mao S, Zhang X, Zhao Y, Li X, Wang Z, Zhou P, Wang Z, Zhang X, Hu X, Huang G, Xie W.   +10 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

RGS20 reduces glioma stemness and temozolomide resistance by intrinsically inhibiting the WNT/β-catenin signaling pathway. [PDF]

Sci Rep
Xie Y, Li Q, Ma Y, Yang Y, Jin X, Yi T, Ge X, Xu X, Yang X, Huang Q, Lu Y, Li P, Li W, Wang X, Piao Y, Jin X.   +15 more
europepmc   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Searching for biological processes as targets for rheumatoid arthritis targeted therapy with ANDSystem, an integrated software and information platform. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Mishchenko EL, Yatsyk IV, Demenkov PS, Adamovskaya AV, Ivanisenko TV, Kleshchev MA, Ivanisenko VA.   +6 more
europepmc   +1 more source