Results 31 to 40 of about 176,136 (293)
Frontiers in Pharmacology, 2021 The Wnt/β-catenin signaling pathway plays important roles in embryonic development and tissue homeostasis. Wnt signaling is induced, and β-catenin is activated, associated with the development and progression of renal fibrosis. Wnt/β-catenin controls the
Shan-Shan Li +8 more
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CellsUpon engagement of one of the nineteen secreted Wnt signaling proteins with one of the ten Frizzled transmembrane Wnt receptors (FZD1–10), a wide variety of cellular Wnt signaling responses can be elicited, the selectivity of which depends on the ...
Janine Wesslowski +4 more
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Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome). [PDF]
PLoS ONE, 2012 Focal Dermal Hypoplasia (FDH) is a genetic disorder characterized by developmental defects in skin, skeleton and ectodermal appendages. FDH is caused by dominant loss-of-function mutations in X-linked PORCN.
Wei Liu +7 more
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Hipk proteins dually regulate Wnt/Wingless signal transduction [PDF]
Fly, 2012 The Wnt/Wingless (Wg) pathway is an evolutionarily conserved signaling system that is used reiteratively, both spatially and temporally, to control the development of multicellular animals. The stability of cytoplasmic β-catenin/Armadillo, the transcriptional effector of the pathway, is controlled by sequential N-terminal phosphorylation and ...
Esther M, Verheyen +2 more
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Scientific Reports, 2022 The Wnt family features conserved glycoproteins that play roles in tissue regeneration, animal development and cell proliferation and differentiation. For its functional diversity and importance, this family has been studied in several species, but not ...
Cuili Pan +9 more
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LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
Frontiers in Cell and Developmental Biology, 2021 The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic development, injury repair and the pathogenesis of human diseases.
Qian Ren +3 more
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Spreading around a Wnt protein [PDF]
Journal of Cell Biology, 2013 ![Figure][1] In a fly lacking Trol, arrows and arrowheads mark the extra boutons in a neuromuscular junction stained for pre- (purple) and postsynaptic (green) markers. Aproteoglycan helps disperse Wnt proteins during development of the neuromuscular junction, [Kamimura et al.][2 ...
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
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Sperm Motility Requires Wnt/GSK3 Stabilization of Proteins [PDF]
Developmental Cell, 2015 Inhibition of GSK3 by Wnt signaling stabilizes many cellular proteins, but proof that this effect is independent of β-catenin-mediated transcription is lacking. Koch, Acebron, and colleagues (2015) now demonstrate that transcriptionally silent mammalian sperm require Wnt signaling via exosomes to prevent protein degradation during their lengthy travels
De Robertis, Edward M, Ploper, Diego
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Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source