Results 51 to 60 of about 259,205 (374)
Interaction of Wnt-1 proteins with the binding protein BiP. [PDF]
Molecular and Cellular Biology, 1992 The mouse Wnt-1 gene, a target for insertional activation in mouse mammary tumor virus-induced mammary tumors, encodes poorly secreted, cysteine-rich glycoproteins required for proper central nervous system development. We have been analyzing the biosynthesis of Wnt-1 proteins in several cell lines that express Wnt-1 cDNA from heterologous promoters. A
Harold E. Varmus +2 more
openaire +3 more sources
Targeted protein degradation systems to enhance Wnt signaling
eLife, 2023 Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. Human hepatic lectin, asialoglycoprotein receptor (ASGR) is selectively expressed on hepatocytes. We have previously engineered an anti-ASGR1 antibody-mutant RSPO2 (RSPO2RA) fusion protein (called SWEETS TM ) to drive tissue-specific degradation of ...
Heekyung Jung +12 more
openaire +3 more sources
Scientific Reports, 2022 The Wnt family features conserved glycoproteins that play roles in tissue regeneration, animal development and cell proliferation and differentiation. For its functional diversity and importance, this family has been studied in several species, but not ...
Cuili Pan +9 more
doaj +1 more source
LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
Frontiers in Cell and Developmental Biology, 2021 The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic development, injury repair and the pathogenesis of human diseases.
Qian Ren +3 more
doaj +1 more source
Target specific peptide design using latent space approximate trajectory collector [PDF]
arXiv, 2023 Despite the prevalence and many successes of deep learning applications in de novo molecular design, the problem of peptide generation targeting specific proteins remains unsolved. A main barrier for this is the scarcity of the high-quality training data. To tackle the issue, we propose a novel machine learning based peptide design architecture, called
arxiv
Current perspectives of the signaling pathways directing neural crest induction. [PDF]
, 2012 The neural crest is a migratory population of embryonic cells with a tremendous potential to differentiate and contribute to nearly every organ system in the adult body.
García-Castro, Martín I +1 more
core +2 more sources
Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling. [PDF]
PLoS ONE, 2011 Canonical Wnt signaling is controlled intracellularly by the level of β-catenin protein, which is dependent on Axin scaffolding of a complex that phosphorylates β-catenin to target it for ubiquitylation and proteasomal degradation.
Marinella G Callow +14 more
doaj +1 more source
Dickkopf1 - a new player in modelling the Wnt pathway [PDF]
, 2010 The Wnt signalling pathway transducing the stabilization of beta-catenin is essential for metazoan embryo development and is misregulated in many diseases such as cancers. In recent years models have been proposed for the Wnt signalling pathway during the segmentation process in developing embryos.
arxiv +1 more source
Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth [PDF]
, 2017 Bone morphogenetic proteins (Bmp) are well-known to induce bone formation following chondrogenesis, but the direct role of Bmp signaling in the osteoblast lineage is not completely understood.
Bellido, Teresita +5 more
core +2 more sources
, 2019 The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years.
Aleithe, S. +20 more
core +1 more source