Results 181 to 190 of about 5,645,262 (348)
Aberrant activation of Wnt signaling pathway altered osteocyte mineralization
, 2019 Mineralization of bone is a dynamic process, involving a complex interplay between cells, secreted macromolecules, signaling pathways, and enzymatic reactions; the dysregulation of bone mineralization may lead to serious skeletal disorders, including ...
Zhou, Yinghong +13 more
core +1 more source
Advanced Science, EarlyView.Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi +7 more
wiley +1 more source
Identification of target cell signaling responsiveness to small molecules using in vivo biosensors
, 2022 reservedIntroduzione: Le vie di segnalazione intracellulari costituiscono un sistema integrato di trasmissione dell’informazione biologica, potenzialmente recepita a livello della membrana cellulare, per l’avvio di un programma coordinato di trascrizione
PIOVAN, BEATRICE
core
Advanced Science, EarlyView.A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick +8 more
wiley +1 more source
Eafs Control Erythroid Cell Fate by Regulating c-myb Expression through Wnt Signaling
, 2013 ELL associated factor 1 and ELL associated factor 2 (EAF1/2 factors) are reported to play important roles in tumor suppression and embryogenesis. Our previous studies showed that eaf factors mediated effective convergence and extension (C&E) movements ...
Liu, JX (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China. +2 more
core +1 more source
Traction Force Microscopy for Viscoelastic Substrates: A Semi‐Analytical Method
Advanced Science, EarlyView.A semi‐analytical viscoelastic traction force microscopy framework is introduced for quantifying time‐resolved cell tractions on flat finite‐thickness substrates. The method generalizes elastic traction force microscopy to Generalized Maxwell materials, identifies when elastic approximations remain valid and, when they do not, shows that inferred ...
Adrià Villacrosa‐Ribas +10 more
wiley +1 more source
Characterisation of Aardvark, a Dictyostelium ß-catenin. [PDF]
, 2003 Wnt signalling is active both in development and the progression of certain disease processes, most notably cancer. Glycogen Synthase Kinase-3 (GSK-3) and ß-catenin both define the canonical Wnt pathway, where GSK-3 negatively regulates ß-catenin ...
Reynolds, Jonathan Peter, Reynolds, JP
core
Advanced Science, EarlyView.METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu +7 more
wiley +1 more source
Wnt/beta-catenin signaling in development and disease.
Cell, 2006 H. Clevers
semanticscholar +1 more source
Structural and Functional Insights into Dishevelled-Mediated Wnt Signaling
Dishevelled (DVL) proteins precisely control Wnt signaling pathways with many effectors. While substantial research has advanced our understanding of DVL’s role in Wnt pathways, key questions regarding its regulatory mechanisms and interactions ...
Rui Zhu +6 more
core +1 more source