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Effects of the WNT signaling pathway on inflammation and fibrosis in idiopathic pulmonary fibrosis: Clinical, radiological and molecular evaluation. [PDF]
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Prickle and Ror modulate Dishevelled-Vangl interaction to regulate non-canonical Wnt signaling during convergent extension in <i>Xenopus</i>. [PDF]
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Wnt signaling in periodontitis
Clinical Oral Investigations, 2023This study aimed to evaluate the Wnt/β-catenin signaling pathway activity in gingival samples obtained from patients with periodontitis.Fifteen patients with stage III grade B (SIIIGB) and eleven with stage III grade C (SIIIGC) periodontitis were included and compared to 15 control subjects.
ÖNDER, CANAN +7 more
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WNT signalling and haematopoiesis: a WNT–WNT situation
Nature Reviews Immunology, 2005The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic ...
Staal, Frank, Clevers, HC
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Wnt signaling and osteoarthritis
Bone, 2009Osteoarthritis is a common disease, clinically manifested by joint pain, swelling and progressive loss of function. The severity of disease manifestations can vary but most of the patients only need intermittent symptom relief without major interventions.
Frank P, Luyten +2 more
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Wnt signaling and osteoblastogenesis
Reviews in Endocrine and Metabolic Disorders, 2006Wnts are a large family of growth factors that mediate fundamental biological processes like embryogenesis, organogenesis and tumorigenesis. These proteins bind to a membrane receptor complex comprised of a frizzled (FZD) G-protein-coupled receptor (GPCRs) and a low-density lipoprotein (LDL) receptor-related protein (LRP).
Peter V N, Bodine, Barry S, Komm
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Current Opinion in Immunology, 2003
Wnt proteins are secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis in many different tissues and species. Wnt signaling is required for normal thymocyte development, most dramatically at the pro-T-cell stage, although recent reports also indicate a role for Wnt proteins in later stages of thymocyte ...
Staal, Frank, Clevers, HC
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Wnt proteins are secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis in many different tissues and species. Wnt signaling is required for normal thymocyte development, most dramatically at the pro-T-cell stage, although recent reports also indicate a role for Wnt proteins in later stages of thymocyte ...
Staal, Frank, Clevers, HC
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Wnt signaling in the vasculature
Angiogenesis, 2002The Wnt signaling pathway regulates normal development as well as a variety of pathologies. Studies of the Wnt pathway have focused largely on very early development and on tumorigenesis. Recent observations point to a role for Wnt signaling in vessel development and pathology. Although not yet investigated systematically, several Wnt ligands have been
A M, Goodwin, P A, D'Amore
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Cancer Biomarkers, 2007
WNT signaling plays a key role in the developing embryo and in the maintenance of a stem/progenitor cell compartment in adult tissues. However, WNT signaling is also believed to play an important role in carcinogenesis. WNT signaling may be activated directly through WNT ligand overexpression, or more often through mutations downstream in the WNT ...
Michael J, Pishvaian, Stephen W, Byers
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WNT signaling plays a key role in the developing embryo and in the maintenance of a stem/progenitor cell compartment in adult tissues. However, WNT signaling is also believed to play an important role in carcinogenesis. WNT signaling may be activated directly through WNT ligand overexpression, or more often through mutations downstream in the WNT ...
Michael J, Pishvaian, Stephen W, Byers
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