Results 311 to 320 of about 5,645,262 (348)
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Wnt signaling pathway in aging-related tissue fibrosis and therapies.
Ageing Research Reviews, 2020Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the pathogenesis of various chronic diseases and aging-related organ failure to fully control chronic wound-healing and restoring tissue function.
He-He Hu +4 more
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Cancer Biomarkers, 2007
WNT signaling plays a key role in the developing embryo and in the maintenance of a stem/progenitor cell compartment in adult tissues. However, WNT signaling is also believed to play an important role in carcinogenesis. WNT signaling may be activated directly through WNT ligand overexpression, or more often through mutations downstream in the WNT ...
Michael J, Pishvaian, Stephen W, Byers
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WNT signaling plays a key role in the developing embryo and in the maintenance of a stem/progenitor cell compartment in adult tissues. However, WNT signaling is also believed to play an important role in carcinogenesis. WNT signaling may be activated directly through WNT ligand overexpression, or more often through mutations downstream in the WNT ...
Michael J, Pishvaian, Stephen W, Byers
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Wnt signaling in the vasculature
Experimental Cell Research, 2013The development of the vascular system requires orchestrated activities of various molecular pathways to assure the formation of a hierarchically branched tubular network. Furthermore, endothelial cell (EC) populations are heterogeneous to meet organ-specific requirements in the mature vasculature. This developmental scheme is probably best represented
Marco, Reis, Stefan, Liebner
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Wnt signaling and osteoarthritis
Bone, 2009Osteoarthritis is a common disease, clinically manifested by joint pain, swelling and progressive loss of function. The severity of disease manifestations can vary but most of the patients only need intermittent symptom relief without major interventions.
Frank P, Luyten +2 more
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2020
Wnt molecules are a class of cysteine-rich secreted glycoproteins that participate in various developmental events during embryogenesis and adult tissue homeostasis. Since its discovery in 1982, the roles of Wnt signaling have been established in various key regulatory systems in biology.
Amit, Singla +5 more
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Wnt molecules are a class of cysteine-rich secreted glycoproteins that participate in various developmental events during embryogenesis and adult tissue homeostasis. Since its discovery in 1982, the roles of Wnt signaling have been established in various key regulatory systems in biology.
Amit, Singla +5 more
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2021
The WNT/β-catenin signalling pathway is a rich and complex network of cellular proteins that orchestrates diverse short-range cell-to-cell communication in metazoans and is essential for both embryonic development and adult homeostasis. Due to its fundamental importance in controlling cell behaviour at multiple levels, its deregulation is associated ...
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The WNT/β-catenin signalling pathway is a rich and complex network of cellular proteins that orchestrates diverse short-range cell-to-cell communication in metazoans and is essential for both embryonic development and adult homeostasis. Due to its fundamental importance in controlling cell behaviour at multiple levels, its deregulation is associated ...
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Targeting Oncogenic WNT Signalling with WNT Signalling-Derived Peptides
2021WNT signalling is known to be a crucial regulator of embryonic development and tissue homeostasis. Aberrant expression of WNT signalling elements or their mutations has been implicated in carcinogenesis and/or the progression of several different cancer types.
Vikas, Yadav +3 more
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2008
Cnidarians are an ancient group of animals at the base of metazoan evolution. They exhibit a simple body plan with only one well-defined body axis and a small number of cell types. Cnidarians are also well known for their enormous regeneration capacity.
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Cnidarians are an ancient group of animals at the base of metazoan evolution. They exhibit a simple body plan with only one well-defined body axis and a small number of cell types. Cnidarians are also well known for their enormous regeneration capacity.
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Trends in Genetics, 2004
Recent research on the WNT signaling pathway warrants a reassessment of the basic mechanism that transmits signal from the membrane-bound receptor to the nucleus. This article incorporates these findings into a revised model for pathway activation. We propose that the control of Axin stability, rather than the control of ZW3 phosphorylation of the ...
Nicholas S, Tolwinski, Eric, Wieschaus
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Recent research on the WNT signaling pathway warrants a reassessment of the basic mechanism that transmits signal from the membrane-bound receptor to the nucleus. This article incorporates these findings into a revised model for pathway activation. We propose that the control of Axin stability, rather than the control of ZW3 phosphorylation of the ...
Nicholas S, Tolwinski, Eric, Wieschaus
openaire +2 more sources
2014
Osteosarcoma (OS) is the most common primary bone malignancy diagnosed in children and adolescents with a high propensity for local invasion and distant metastasis. Despite current multidisciplinary treatments, there has not been a drastic change in overall prognosis within the last two decades.
Carol H, Lin +3 more
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Osteosarcoma (OS) is the most common primary bone malignancy diagnosed in children and adolescents with a high propensity for local invasion and distant metastasis. Despite current multidisciplinary treatments, there has not been a drastic change in overall prognosis within the last two decades.
Carol H, Lin +3 more
openaire +2 more sources