Results 1 to 10 of about 765,056 (100)
Progress of Wnt Signaling Pathway in Osteoporosis
Biomolecules, 2023 Osteoporosis, one of the serious health diseases, involves bone mass loss, bone density diminishing, and degeneration of bone microstructure, which is accompanied by a tendency toward bone fragility and a predisposition to fracture. More than 200 million
Yongguang Gao +3 more
semanticscholar +1 more source
The Wnt Signaling Pathway in Diabetic Nephropathy
Frontiers in Cell and Developmental Biology, 2022 Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2 diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease. DN can lead to hypertension, edema, and proteinuria. In some cases, DN can
Haiying Wang +9 more
semanticscholar +1 more source
Roles of the Wnt Signaling Pathway in Head and Neck Squamous Cell Carcinoma
Frontiers in Molecular Biosciences, 2021 Head and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck tumor. It is a high incidence malignant tumor associated with a low survival rate and limited treatment options.
Jing Xie +3 more
semanticscholar +1 more source
SMAD4 activates Wnt signaling pathway to inhibit granulosa cell apoptosis
Cell Death and Disease, 2020 The TGF-β and Wnt signaling pathways are interrelated in many cell types and tissues, and control cell functions in coordination. Here, we report that SMAD4, a downstream effector of the TGF-β signaling pathway, induces FZD4, a receptor of the Wnt ...
Xing Du +5 more
semanticscholar +1 more source
The Wnt signaling pathway in development and disease.
Annual Review of Cell and Developmental Biology, 2004 Tight control of cell-cell communication is essential for the generation of a normally patterned embryo. A critical mediator of key cell-cell signaling events during embryogenesis is the highly conserved Wnt family of secreted proteins.
C. Logan, R. Nusse
semanticscholar +1 more source
The role of Wnt signaling pathway in tumor metabolic reprogramming
Journal of Cancer, 2019 The occurrence and development of tumors is a complex process involving long-term multi-factor participation. In this process, tumor cells from a set of abnormal metabolic patterns that are different from normal cells.
Yongzhen Mo +11 more
semanticscholar +1 more source
The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators.
Annual Review of Biochemistry, 2022 The Wnt pathway is central to a host of developmental and disease-related processes. The remarkable conservation of this intercellular signaling cascade throughout metazoan lineages indicates that it coevolved with multicellularity to regulate the ...
E. Y. Rim, H. Clevers, R. Nusse
semanticscholar +1 more source
Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder
Translational Psychiatry, 2018 The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the function and structure of the adult nervous system.
E. Hoseth +13 more
semanticscholar +1 more source
Targeting the Wnt/β-catenin signaling pathway in cancer
Journal of Hematology & Oncology, 2020 The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response.
Ya Zhang, Xin Wang
semanticscholar +1 more source
Journal of experimental & clinical cancer research : CR, 2018 40–50% of colorectal cancer (CRC) patients develop metastatic disease; the presence of metastasis hinders the effective treatment of cancer through surgery, chemotherapy and radiotherapy, which makes 5-year survival rate extremely low; therefore ...
Mengmeng Zhang +14 more
semanticscholar +1 more source