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Progress of Wnt Signaling Pathway in Osteoporosis [PDF]
Biomolecules, 2023 Osteoporosis, one of the serious health diseases, involves bone mass loss, bone density diminishing, and degeneration of bone microstructure, which is accompanied by a tendency toward bone fragility and a predisposition to fracture. More than 200 million
Yongguang Gao +3 more
doaj +5 more sources
The Wnt Signaling Pathway in Diabetic Nephropathy [PDF]
Frontiers in Cell and Developmental Biology, 2022 Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2 diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease. DN can lead to hypertension, edema, and proteinuria. In some cases, DN can
Haiying Wang +9 more
semanticscholar +4 more sources
The Wnt signaling pathway in cancer. [PDF]
Critical Reviews in Oncology/Hematology, 2016 The Wnt signaling pathway is critically involved in both the development and homeostasis of tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been described as a key player in the initiation of and/or maintenance and development of many cancers, via affecting the behavior of Cancer Stem Cells (CSCs).
Yann Duchartre, Yong-Mi Kim, M. Kahn
semanticscholar +4 more sources
The Wnt signaling pathway in development and disease. [PDF]
Annual Review of Cell and Developmental Biology, 2004 Tight control of cell-cell communication is essential for the generation of a normally patterned embryo. A critical mediator of key cell-cell signaling events during embryogenesis is the highly conserved Wnt family of secreted proteins.
C. Logan, R. Nusse
semanticscholar +4 more sources
Wnt Signaling Pathway in Tumor Biology. [PDF]
Genes (Basel)Relapse and metastasis are the major challenges that stand in the way of cancer healing and survival, mainly attributed to cancer stem cells (CSCs). Their capabilities of self-renewal and tumorigenic potential leads to treatment resistance development. CSCs function through signaling pathways such as the Wnt/β-catenin cascade.
Iluta S, Nistor M, Buruiana S, Dima D.
europepmc +4 more sources
Autophagy and the Wnt Signaling Pathway: A Focus on Wnt/β-catenin signaling.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020 Cellular homeostasis and adaptation to various environmental conditions are importantly regulated by the sophisticated mechanism of autophagy and its crosstalk with Wnt signaling and other developmental pathways. Both autophagy and Wnt signaling are involved in embryogenesis and differentiation. Autophagy is responsible for degradation and recycling of
Shahrokh Lorzadeh +3 more
semanticscholar +3 more sources
Secreted antagonists of the Wnt signalling pathway [PDF]
Journal of Cell Science, 2003 The extracellular antagonists of the Wnt signalling pathway can be divided into two broad classes. Both classes of molecule prevent ligand-receptor interactions, but by different mechanisms: members of the first class, which include the sFRP (secreted Frizzled-related protein) family, WIF (Wnt inhibitory factor)-1 and Cerberus, primarily bind to Wnt ...
Yoshiaki Kawano, Robert Kypta
openalex +4 more sources
Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development [PDF]
Organogenesis, 2023 It is known to all that Wnt signaling pathway plays an important role in the early development of tooth. Our previous research found that Wnt signaling pathway played crucial roles in dental development, and mutations in antagonist of Wnt signaling ...
Yuhan Song +4 more
doaj +2 more sources
Wnt signaling pathway in retinal vascularization
Eye and Brain, 2016 Wnt-signaling, a ubiquitous pathway that directs differentiation, cell polarity, and tissue specificity, has been implicated as an important gene-expression pathway in retinal development.
K. Drenser
semanticscholar +6 more sources
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
Journal of Hematology & OncologyThe Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development, tissue homeostasis, and cell proliferation.
Pan Song +7 more
doaj +2 more sources