Results 11 to 20 of about 289,302 (355)
Progress of Wnt Signaling Pathway in Osteoporosis
Biomolecules, 2023 Osteoporosis, one of the serious health diseases, involves bone mass loss, bone density diminishing, and degeneration of bone microstructure, which is accompanied by a tendency toward bone fragility and a predisposition to fracture. More than 200 million
Yongguang Gao +3 more
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Wnt signal transduction pathways [PDF]
Organogenesis, 2008 The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development. The Wnts are secreted glycoproteins and comprise a large family of nineteen proteins in humans hinting to a daunting ...
Yuko, Komiya, Raymond, Habas
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Wnt Signaling Pathway in Tumor Biology. [PDF]
Genes (Basel)Relapse and metastasis are the major challenges that stand in the way of cancer healing and survival, mainly attributed to cancer stem cells (CSCs). Their capabilities of self-renewal and tumorigenic potential leads to treatment resistance development. CSCs function through signaling pathways such as the Wnt/β-catenin cascade.
Iluta S, Nistor M, Buruiana S, Dima D.
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The Wnt signalling pathway [PDF]
Journal of Cell Science, 2002 Recent advances in the field require an update of our Wnt pathway scheme ( [Hulsken and Behrens, 2000][1]). Intracellular signaling of the Wnt pathway diversifies into at least three branches: (1) the β-catenin pathway (canonical Wnt pathway, blue), which activates target genes in the nucleus ...
Joerg, Huelsken, Juergen, Behrens
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Wnt/β-catenin signaling pathway in lung cancer
Medicine in Drug Discovery, 2022 The Wnt signaling pathway regulates cell proliferation, differentiation, migration, genetic stability, and apoptosis in almost all tissues and organs. It plays a crucial role in the normal development of embryos and the dynamic balance of adult tissues ...
Wenhua Zhu, Heng Wang, Di Zhu
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Wnt Signaling Pathways in Keratinocyte Carcinomas [PDF]
Cancers, 2019 The skin functions as a barrier between the organism and the surrounding environment. Direct exposure to external stimuli and the accumulation of genetic mutations may lead to abnormal cell growth, irreversible tissue damage and potentially favor skin malignancy.
Christopher M. R. Lang +3 more
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Role of the Wnt signaling molecules in the tooth
Japanese Dental Science Review, 2016 Wnt signaling plays a central role in many processes during embryonic development and adult homeostasis. At least 19 types of Wnt ligands, receptors, transducers, transcription factors, and antagonists have been identified in mammals.
Masato Tamura, PhD, DDS +1 more
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Biomolecules, 2023 The WNT signaling pathway plays a critical role in a variety of biological processes, including development, adult tissue homeostasis maintenance, and stem cell regulation.
Ruoxue Bai +5 more
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Wnt signaling pathways meet Rho GTPases [PDF]
Genes & Development, 2009 Wnt ligands and their receptors orchestrate many essential cellular and physiological processes. During development they control differentiation, proliferation, migration, and patterning, while in the adult, they regulate tissue homeostasis, primarily through their effects on stem cell proliferation and differentiation.
Karni, Schlessinger +2 more
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Role of Wnt canonical pathway in hematological malignancies
Journal of Hematology & Oncology, 2010 Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt/β-catenin signaling pathway is involved in the pathogenesis of many carcinomas.
Wang Xin, GE Xueling
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