Results 21 to 30 of about 289,302 (355)

Research progress of the role of non-canonical Wnt signaling pathway in ovarian cancer and its potential therapeutic implications

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Ovarian cancer is a malignant tumor of the female reproductive system with the highest mortality, and involves the aberrant regulation of multiple molecular signaling pathways.
ZHOU Wanzhen, TENG Yincheng
doaj   +1 more source

The Wnt signaling pathway in cancer [PDF]

Critical Reviews in Oncology/Hematology, 2016
The Wnt signaling pathway is critically involved in both the development and homeostasis of tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been described as a key player in the initiation of and/or maintenance and development of many cancers, via affecting the behavior of Cancer Stem Cells (CSCs).
Yann Duchartre, Yong-Mi Kim, Michael Kahn   +2 more
openaire   +2 more sources

A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin. [PDF]

, 2017
Cellular proliferation is antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the noncanonical Wnt ...
Aznar, Nicolas, Buschman, Matthew D, Dunkel, Ying, Ear, Jason, Ghosh, Pradipta, Sun, Nina   +5 more
core   +3 more sources

IGFBP-3 inhibits Wnt signaling in metastatic melanoma cells. [PDF]

, 2016
In previous works, we have shown that insulin-like growth factor-binding protein-3 (IGFBP-3), a tissue and circulating protein able to bind to IGFs, decreases drastically in the blood serum of patients with diffuse metastatic melanoma.
Londei, Paola, Martella, M, Naspi, A, Panasiti, Vincenzo, Polinari, Dorina, Rosa Alba, R, Sancillo, L, Zingariello, M   +7 more
core   +1 more source

SnapShot: Noncanonical Wnt Signaling Pathways

Cell, 2007
Noncanonical Wnt signaling is defined here as Wnt- or Fz-initiated signaling that is independent of β-catenin transcriptional function. Noncanonical Wnt pathways are diverse and in many cases less characterized/defined. They are grouped into several categories for clarity and simplicity.
Semenov, Mikhail V., Habas, Raymond, MacDonald, Bryan T., He, Xi   +3 more
openaire   +2 more sources

The Wnt Signaling Pathway in Diabetic Nephropathy [PDF]

Frontiers in Cell and Developmental Biology, 2022
Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2 diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease. DN can lead to hypertension, edema, and proteinuria. In some cases, DN can even progress to kidney failure, a life-threatening condition.
Haiying Wang, Ran Zhang, Xinjie Wu, Yafen Chen, Wei Ji, Jingsuo Wang, Yawen Zhang, Yong Xia, Yiqun Tang, Jinxiang Yuan   +9 more
openaire   +3 more sources

Regulation of SUMOylation Targets Associated With Wnt/β-Catenin Pathway

Frontiers in Oncology, 2022
Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology.
Linlin Fan, Xudong Yang, Minying Zheng, Xiaohui Yang, Yidi Ning, Ming Gao, Shiwu Zhang   +6 more
doaj   +1 more source

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson, Adams, Aicher, Armulik, Arosarena, Augustin, Benedito, Bergers, Blouw, Brastianos, Cancer Genome Atlas Research Network, Carmeliet, Cathrin J. Czupalla, Cattelino, Chien, Claxton, Corada, Daneman, Daneman, Devraj, Ernesto Bockamp, Estrach, Fisher, Franco, Gerhardt, Gerhardt, Harada, Harrington, Hellström, Jadranka Macas, Jakobsson, Jenny Zinke, Kamino, Karl H. Plate, Kavi Devraj, Kotliarova, Li, Liebner, Liebner, Liebner, Liebner, Lobov, Lobov, Lucero, Machein, Mailhos, Makoto M. Taketo, Marco Reis, Marcus Fruttiger, McCarty, Min, Nicole Ziegler, Noguera-Troise, Olsson, Phng, Phng, Rosario Heck, Saharinen, Sascha Seidel, Schneider, Segarra, Siekmann, Smadja, Smolich, Sonja Thom, Stefan Liebner, Stefanie Dimmeler, Stenman, Streit, Thomas, Vleminckx, Willert, Williams, Wolburg, Yano, Yano, Yoshio-Hoshino, Zhang, Zhang, Zhou   +79 more
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Porcine Circovirus-Like Virus P1 Inhibits Wnt Signaling Pathway in Vivo and in Vitro

Frontiers in Microbiology, 2018
Porcine circovirus-like virus P1 is an important pathogen of the current pig industry, the infection mechanism is not entirely clear. Wnt signaling pathway plays an important role in the growth of young animals and infection of some viruses.
Xuejiao Zhu, Xuejiao Zhu, Xuejiao Zhu, Libin Wen, Libin Wen, Libin Wen, Shaoyang Sheng, Shaoyang Sheng, Wei Wang, Wei Wang, Wei Wang, Qi Xiao, Qi Xiao, Qi Xiao, Meng Qu, Meng Qu, Yiyi Hu, Yiyi Hu, Yiyi Hu, Chuanmin Liu, Chuanmin Liu, Chuanmin Liu, Kongwang He, Kongwang He, Kongwang He   +24 more
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Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway

Acta Biochimica et Biophysica Sinica, 2023
Roof plate-specific spondin 1 (R-spondin1, RSPO1) is a Wnt/β-catenin signaling pathway activator that binds with Wnt ligands to stimulate the Wnt/β-catenin signaling pathway, which is key to hair regeneration. However, it is not clear whether recombinant
Chen Yijun, Lu Zhujin, Feng Jiaxin, Chen Zefeng, Liu Zejian, Wang Xiuqi, Yan Huichao, Gao Chunqi   +7 more
doaj   +1 more source