Results 21 to 30 of about 1,031,479 (367)
An update on Wnt signaling pathway in cancer [PDF]
Translational Cancer Research, 2020 Wnt signaling involves many aspects of development, cell biology and physiology. Mutations in the Wnt gene can lead to abnormal embryonic development and cancer formation, including various aspects that affect proliferation, morphogenesis, and differentiation. The occurrence and development of tumors is a complex process involving multiple factors. The
Guoqing Ying +3 more
openaire +3 more sources
Wnt/β-catenin signaling pathway inhibits the proliferation and apoptosis of U87 glioma cells via different mechanisms. [PDF]
PLoS ONE, 2017 The Wnt signaling pathway is necessary for the development of the central nervous system and is associated with tumorigenesis in various cancers. However, the mechanism of the Wnt signaling pathway in glioma cells has yet to be elucidated. Small-molecule
Liyang Gao +6 more
doaj +1 more source
SnapShot: Noncanonical Wnt Signaling Pathways [PDF]
Cell, 2007 Noncanonical Wnt signaling is defined here as Wnt- or Fz-initiated signaling that is independent of β-catenin transcriptional function. Noncanonical Wnt pathways are diverse and in many cases less characterized/defined. They are grouped into several categories for clarity and simplicity.
Raymond Habas +3 more
openaire +2 more sources
Interaction of viral oncogenic proteins with the Wnt signaling pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2018 It is estimated that up to 20% of all types of human cancers worldwide are attributed to viruses. The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation.
Sayyad Khanizadeh +4 more
doaj +1 more source
mBio, 2023 The segmented negative-strand RNA viruses (sNSVs) include highly pathogenic human and animal viruses such as Lassa virus (LASV), severe fever with thrombocytopenia syndrome virus (SFTSV), and influenza A virus (IAV).
Xia-Ming Jiang +9 more
doaj +1 more source
Wnt Signaling Pathways in Keratinocyte Carcinomas [PDF]
Cancers, 2019 The skin functions as a barrier between the organism and the surrounding environment. Direct exposure to external stimuli and the accumulation of genetic mutations may lead to abnormal cell growth, irreversible tissue damage and potentially favor skin malignancy.
Christopher M. R. Lang +3 more
openaire +3 more sources
A CRISPR knockout screen reveals new regulators of canonical Wnt signaling
Oncogenesis, 2021 The Wnt signaling pathways play fundamental roles during both development and adult homeostasis. Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including cancer, and is especially implicated in the ...
Tamar Evron +9 more
doaj +1 more source
SMAD4 activates Wnt signaling pathway to inhibit granulosa cell apoptosis
Cell Death and Disease, 2020 The TGF-β and Wnt signaling pathways are interrelated in many cell types and tissues, and control cell functions in coordination. Here, we report that SMAD4, a downstream effector of the TGF-β signaling pathway, induces FZD4, a receptor of the Wnt ...
Xing Du +5 more
semanticscholar +1 more source
The WNT signalling pathway and diabetes mellitus [PDF]
Diabetologia, 2008 The WNT signalling pathway is involved in many physiological and pathophysiological activities. WNT ligands bind to Frizzled receptors and co-receptors (LDL receptor-related protein 5/6), triggering a cascade of signalling events. The major effector of the canonical WNT signalling pathway is the bipartite transcription factor beta-catenin/T cell ...
Tianru Jin, Tianru Jin
openaire +3 more sources
Regulation of SUMOylation Targets Associated With Wnt/β-Catenin Pathway
Frontiers in Oncology, 2022 Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology.
Linlin Fan +6 more
doaj +1 more source