Results 31 to 40 of about 1,026,340 (233)

Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]

, 2017
BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves, Couraud, Pierre-Olivier, Mauborgne, Annie, Moreau, Nathan, Pohl, Michel, Romero, Ignacio A, Villanueva, Luis, Weksler, Babette B   +7 more
core   +3 more sources

Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway

Acta Biochimica et Biophysica Sinica, 2023
Roof plate-specific spondin 1 (R-spondin1, RSPO1) is a Wnt/β-catenin signaling pathway activator that binds with Wnt ligands to stimulate the Wnt/β-catenin signaling pathway, which is key to hair regeneration. However, it is not clear whether recombinant
Chen Yijun, Lu Zhujin, Feng Jiaxin, Chen Zefeng, Liu Zejian, Wang Xiuqi, Yan Huichao, Gao Chunqi   +7 more
doaj   +1 more source

IGFBP-3 inhibits Wnt signaling in metastatic melanoma cells. [PDF]

, 2016
In previous works, we have shown that insulin-like growth factor-binding protein-3 (IGFBP-3), a tissue and circulating protein able to bind to IGFs, decreases drastically in the blood serum of patients with diffuse metastatic melanoma.
Londei, Paola, Martella, M, Naspi, A, Panasiti, Vincenzo, Polinari, Dorina, Rosa Alba, R, Sancillo, L, Zingariello, M   +7 more
core   +1 more source

Squalene activates Wnt/β-Catenin signaling pathway to mediate NF-κB pathway to regulate inflammatory response and disease resistance in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu)

Aquaculture Reports, 2023
We previously found that squalene may influence immunity of grouper by affecting the Wnt/β-Catenin signaling pathway, but the exact mechanism is uncertain.
Xiaobo Yan, Simiao Pan, Tao Li, Weibin Huang, Menglong Zhou, Shuang Zhang, Yuanzhi Yang, Beiping Tan, Xiaohui Dong   +8 more
doaj  

Dapper-1 is essential for Wnt5a induced cardiomyocyte hypertrophy by regulating the Wnt/PCP pathway [PDF]

, 2014
The Wnt signaling pathway was identified as crucial mediator of cardiomyocyte hypertrophy. In this study we found that activation of non-canonical Wnt signaling by Wnt5a stimulates protein synthesis and enlargement of cardiomyocyte surface area.
Bernhold, Elmar, Fan, Jingjing, Hagenmueller, Marco, Hardt, Stefan E., Katus, Hugo A., Riffel, Johannes H.   +5 more
core   +1 more source

Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling

Frontiers in Cell and Developmental Biology, 2021
Primary cilia act as crucial regulators of embryo development and tissue homeostasis. They are instrumental for modulation of several signaling pathways, including Hedgehog, WNT, and TGF-β.
Ondrej Bernatik, Petra Paclikova, Anna Kotrbova, Vitezslav Bryja, Lukas Cajanek   +4 more
doaj   +1 more source

Inhibition of Oncogenic Wnt Signaling through Direct Targeting of β-Catenin [PDF]

, 2014
Aberrant activation of signaling by the Wnt pathway is strongly implicated in the onset and progression of numerous types of cancer. Owing to the persistent dependence of these tumors on Wnt signaling for growth and survival, inhibition of this pathway ...
Bowman, Brian R., Chu, Qian, Grossmann, Tom N., Moellering, Raymond E., Verdine, Gregory L., Yeh, Johannes Johannes   +5 more
core   +1 more source

WNT signaling in neuronal maturation and synaptogenesis [PDF]

, 2013
The Wnt signaling pathway plays a role in the development of the central nervous system and growing evidence indicates that Wnts also regulates the structure and function of the adult nervous system.
Nibaldo C. Inestrosa, Silvana B. Rosso
core   +1 more source

The recent progress of peptide regulators for the Wnt/β-catenin signaling pathway

Frontiers in Medicine, 2023
Wnt signaling plays an important role in many biological processes such as stem cell self-renewal, cell proliferation, migration, and differentiation.
Nan Zhang, Huaxing Shen, Baobao Chen, Honggang Hu, Chao Liu, Yan Chen, Wei Cong   +6 more
doaj   +1 more source

Targeting the Wnt pathways for therapies [PDF]

, 2014
The Wnt/β-catenin signaling pathway is crucial in animal development from sponges to humans. Its activity in the adulthood is less general, with exceptions having huge medical importance.
Blagodatski, A., Katanaev, V.L., Poteryaev, D.   +2 more
core   +1 more source