Results 31 to 40 of about 289,302 (355)
WNT signaling in neuronal maturation and synaptogenesis [PDF]
, 2013 The Wnt signaling pathway plays a role in the development of the central nervous system and growing evidence indicates that Wnts also regulates the structure and function of the adult nervous system.
Nibaldo C. Inestrosa, Silvana B. Rosso
core +1 more source
From individual Wnt pathways towards a Wnt signalling network [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2008 Wnt proteins play important roles during vertebrate and invertebrate development. They obviously have the ability to activate different intracellular signalling pathways. Based on the characteristic intracellular mediators used, these are commonly described as the Wnt/β-catenin, the Wnt/calcium and the Wnt/Jun N-terminal kinase pathways (also called ...
Hans A, Kestler, Michael, Kühl
openaire +2 more sources
Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma
Nature Communications, 2023 The Wnt pathway is frequently dysregulated in many cancers, underscoring it as a therapeutic target. Wnt inhibitors have uniformly failed in clinical trials.
Jing Hao +8 more
doaj +1 more source
The C. Elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway [PDF]
, 2007 Inhibitors of Wnt signaling promote normal development and prevent cancer by restraining when and where the Wnt pathway is activated. ROR proteins, a class of Wnt-binding receptor tyrosine kinases, inhibit Wnt signaling by an unknown mechanism.
Green, Jennifer L. +2 more
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WNT Signaling Pathway and Stem Cell Signaling Network [PDF]
Clinical Cancer Research, 2007 Abstract WNT signals are transduced to the canonical pathway for cell fate determination, and to the noncanonical pathway for control of cell movement and tissue polarity. Canonical WNT signals are transduced through Frizzled family receptors and LRP5/LRP6 coreceptor to the β-catenin signaling cascade.
Masuko, Katoh, Masaru, Katoh
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Inhibition of Oncogenic Wnt Signaling through Direct Targeting of β-Catenin [PDF]
, 2014 Aberrant activation of signaling by the Wnt pathway is strongly implicated in the onset and progression of numerous types of cancer. Owing to the persistent dependence of these tumors on Wnt signaling for growth and survival, inhibition of this pathway ...
Bowman, Brian R. +5 more
core +1 more source
Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]
, 2017 BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves +7 more
core +4 more sources
Wnt Signaling Pathway in Oral Lesions
Journal of the Pakistan Medical Association, 2019 Wingless-Integrated/Beta-catenin (WNT/-catenin) signalling pathway is one of the principal intercellular signalling pathways in humans. It plays an intrinsic role in the cellular proliferation, differentiation and regeneration along with many other cellular functions.
Iqra, Ejaz, Sarah, Ghafoor
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WTX beyond WNT signaling pathway
Visualized Cancer Medicine, 2023 Gastric cancer (GC) is a major malignancy in many developing countries with low early detection rate. As a tumour suppressor gene, WTX inhibits PI3K/AKT/mTOR pathway activity by inhibiting PI3K phosphorylation. WTX loss of WTX protein associates with tumor metastasis and poor survival of GC patients.
Zhang Qingling +3 more
openaire +2 more sources
Targeting the Wnt pathways for therapies [PDF]
, 2014 The Wnt/β-catenin signaling pathway is crucial in animal development from sponges to humans. Its activity in the adulthood is less general, with exceptions having huge medical importance.
Blagodatski, A. +2 more
core +1 more source