Results 41 to 50 of about 1,031,479 (367)

Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway

Acta Biochimica et Biophysica Sinica, 2023
Roof plate-specific spondin 1 (R-spondin1, RSPO1) is a Wnt/β-catenin signaling pathway activator that binds with Wnt ligands to stimulate the Wnt/β-catenin signaling pathway, which is key to hair regeneration. However, it is not clear whether recombinant
Chen Yijun, Lu Zhujin, Feng Jiaxin, Chen Zefeng, Liu Zejian, Wang Xiuqi, Yan Huichao, Gao Chunqi   +7 more
doaj   +1 more source

WNT signaling in neuronal maturation and synaptogenesis [PDF]

, 2013
The Wnt signaling pathway plays a role in the development of the central nervous system and growing evidence indicates that Wnts also regulates the structure and function of the adult nervous system.
Nibaldo C. Inestrosa, Silvana B. Rosso
core   +1 more source

Squalene activates Wnt/β-Catenin signaling pathway to mediate NF-κB pathway to regulate inflammatory response and disease resistance in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu)

Aquaculture Reports, 2023
We previously found that squalene may influence immunity of grouper by affecting the Wnt/β-Catenin signaling pathway, but the exact mechanism is uncertain.
Xiaobo Yan, Simiao Pan, Tao Li, Weibin Huang, Menglong Zhou, Shuang Zhang, Yuanzhi Yang, Beiping Tan, Xiaohui Dong   +8 more
doaj  

Targeting the Wnt pathways for therapies [PDF]

, 2014
The Wnt/β-catenin signaling pathway is crucial in animal development from sponges to humans. Its activity in the adulthood is less general, with exceptions having huge medical importance.
Blagodatski, A., Katanaev, V.L., Poteryaev, D.   +2 more
core   +1 more source

Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma

Nature Communications, 2023
The Wnt pathway is frequently dysregulated in many cancers, underscoring it as a therapeutic target. Wnt inhibitors have uniformly failed in clinical trials.
Jing Hao, Xiangzi Han, Haidong Huang, Xingjiang Yu, Jiankang Fang, Jianjun Zhao, Richard A. Prayson, Shideng Bao, Jennifer S. Yu   +8 more
doaj   +1 more source

Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling

Frontiers in Cell and Developmental Biology, 2021
Primary cilia act as crucial regulators of embryo development and tissue homeostasis. They are instrumental for modulation of several signaling pathways, including Hedgehog, WNT, and TGF-β.
Ondrej Bernatik, Petra Paclikova, Anna Kotrbova, Vitezslav Bryja, Lukas Cajanek   +4 more
doaj   +1 more source

The role of Wnt signaling pathway in tumor metabolic reprogramming

Journal of Cancer, 2019
The occurrence and development of tumors is a complex process involving long-term multi-factor participation. In this process, tumor cells from a set of abnormal metabolic patterns that are different from normal cells.
Yongzhen Mo, Yumin Wang, Lishen Zhang, Liting Yang, Ming Zhou, Xiaoling Li, Yong Li, Gui-yuan Li, Zhaoyang Zeng, W. Xiong, F. Xiong, Can Guo   +11 more
semanticscholar   +1 more source

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson, Adams, Aicher, Armulik, Arosarena, Augustin, Benedito, Bergers, Blouw, Brastianos, Cancer Genome Atlas Research Network, Carmeliet, Cathrin J. Czupalla, Cattelino, Chien, Claxton, Corada, Daneman, Daneman, Devraj, Ernesto Bockamp, Estrach, Fisher, Franco, Gerhardt, Gerhardt, Harada, Harrington, Hellström, Jadranka Macas, Jakobsson, Jenny Zinke, Kamino, Karl H. Plate, Kavi Devraj, Kotliarova, Li, Liebner, Liebner, Liebner, Liebner, Lobov, Lobov, Lucero, Machein, Mailhos, Makoto M. Taketo, Marco Reis, Marcus Fruttiger, McCarty, Min, Nicole Ziegler, Noguera-Troise, Olsson, Phng, Phng, Rosario Heck, Saharinen, Sascha Seidel, Schneider, Segarra, Siekmann, Smadja, Smolich, Sonja Thom, Stefan Liebner, Stefanie Dimmeler, Stenman, Streit, Thomas, Vleminckx, Willert, Williams, Wolburg, Yano, Yano, Yoshio-Hoshino, Zhang, Zhang, Zhou   +79 more
core   +1 more source

Inhibition of Oncogenic Wnt Signaling through Direct Targeting of β-Catenin [PDF]

, 2014
Aberrant activation of signaling by the Wnt pathway is strongly implicated in the onset and progression of numerous types of cancer. Owing to the persistent dependence of these tumors on Wnt signaling for growth and survival, inhibition of this pathway ...
Bowman, Brian R., Chu, Qian, Grossmann, Tom N., Moellering, Raymond E., Verdine, Gregory L., Yeh, Johannes Johannes   +5 more
core   +1 more source

The recent progress of peptide regulators for the Wnt/β-catenin signaling pathway

Frontiers in Medicine, 2023
Wnt signaling plays an important role in many biological processes such as stem cell self-renewal, cell proliferation, migration, and differentiation.
Nan Zhang, Huaxing Shen, Baobao Chen, Honggang Hu, Chao Liu, Yan Chen, Wei Cong   +6 more
doaj   +1 more source