Results 121 to 130 of about 2,631,798 (305)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

“Just Don’t Bore Us To Death”: Seventh Graders’ Perceptions of Flipping a Technology-Mediated English Language Arts Unit [PDF]

, 2018
This mixed methods study aimed to assess student engagement during the flipped model of instruction in two seventh-grade English language arts (ELA) classrooms.
Moran, Clarice M
core   +1 more source

Modelling Early User-Game Interactions for Joint Estimation of Survival Time and Churn Probability

, 2019
Data-driven approaches which aim to identify and predict player engagement are becoming increasingly popular in games industry contexts. This is due to the growing practice of tracking and storing large volumes of in-game telemetries coupled with a ...
Bonometti, Valerio, Drachen, Anders, Hall, Mark, Ringer, Charles, Wade, Alex R.   +4 more
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A Framework for Holistic Assessment of Professional Competencies in Environmental Health WIL at a University of Technology

Education Sciences
The benefits of work-integrated learning (WIL) in higher education are well documented. Conversely, the assessment thereof, across disciplines, remains challenging.
Louella M. Daries, Lizel S. Hudson, Lalini Reddy   +2 more
doaj   +1 more source

Emerging strategies to target metastasis and therapy resistance in melanoma

Molecular Oncology, EarlyView.
Emerging studies propose new approaches to interfere with melanoma progression. In recognition of melanoma awareness month, at Molecular Oncology, we highlight recently published research articles, focusing on novel therapeutic targets driving metastatic spread and outlining different strategies to overcome resistance to BRAF inhibitors and anti‐PD‐1 ...
Amel Aziba
wiley   +1 more source

Evidence of occupational therapy intervention for depression: A rapid review

South African Journal of Occupational Therapy
Introduction: Depression is a leading cause of disability. Occupational therapy interventions address the multifaceted impact of depression by promoting participation and engagement in meaningful activities.
Madri Engelbrecht, Hester Van Biljon, Janke Van der Walt, Shaheed Soeker   +3 more
doaj   +1 more source

Students’ Engagement in School: A literature review [PDF]

, 2012
This work is financed by National Founds through FCT-Fundação para a Ciência e Tecnologia, in the context of the project PTDC/CPE-CED/114362/2009- Students Engagement in Schools: Differentiation and Promotion, coordinated by Prof. Feliciano H.
Almeida, Ana, Bahia, Sara, Caldeira, Suzana, Carvalho, Carolina, CONBOY, JOSEPH, Festas, Maria Isabel, Galvão, Diana, Janeiro, Isabel Nunes, Melo, Madalena, Nogueira, João, Pereira, Tiago, Taveira, Maria do Céu, Veiga, Feliciano Henriques   +12 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source