Results 81 to 90 of about 13,034,377 (234)

Playful Work as a Pathway to Meaningfulness [PDF]

open access: yes
This research examines how the co-existence of work and play can lead to meaningfulness and what this might signify sociologically. Drawing upon forty qualitative interviews with autonomous neo-craft workers in Italy, we contribute the concept of playful
Moraes, Caroline; id_orcid   +1 more
core   +5 more sources

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

The effect of occupational meaningfulness on occupational commitment

open access: yesInternational Journal of Psychological Research, 2013
Existing research lacks a scholarly consensus on how to define and validly measure ‘meaningful work’ (e.g., Rosso, Dekas & Wrzesniewski, 2010). The following correlational study highlights the value of investigating meaningfulness in the context of ...
Itai Ivtzan   +2 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Effectiveness of using Scenario Based Learning Strategy for Nurse’ Managers Cognitive Flexibility on Nurses’ Organizational Excellence and Meaningfulness of Work [PDF]

open access: yesEgyptian Journal of Health Care
Implementing a training program based on the organizational cognitive felxibility using new methods of teaching as secnario based learning for nurse managers significantly improves organizational effectiveness in healthcare settings as organizational ...
Mona Thabet   +2 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The effects of job crafting on subjective well-being amongst South African high school teachers

open access: yesSA Journal of Industrial Psychology, 2016
Orientation: Job crafting can result in a number of positive outcomes for teachers, such as increased meaningfulness and engagement at work. Increased work engagement and psychological meaningfulness may yield positive benefits for the practice of ...
Sergio Peral, Madelyn Geldenhuys
doaj   +1 more source

Positive Sensemaking on the Past Strengthens Work Meaningfulness [PDF]

open access: yes, 2021
학위논문(석사) -- 서울대학교대학원 : 경영대학 경영학과, 2021.8. 박원우.This study aims to study how work meaningfulness could be achieved via justification path when self-realization path is constrained.
지선영
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

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