Results 61 to 70 of about 13,034,377 (234)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

WORK MEANINGFULNESS: EXAMINING S-ABC NEEDS-SUPPLIES FIT AND WORK AS JOBS, CAREERS AND CALLINGS

, 2021
Work meaningfulness is fundamental to how employees approach, enact, and experience tasks and interpersonal relationships, and to maintain mental well-being in the workplace. However, research on the antecedents of work meaningfulness is unbalanced, i.e.,
Zhou, Wenqian
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Beyond “Psychic Income”: An Exploration of Interventions to Address Work-Life Imbalances, Burnout, and Precarity in Contemporary Nonprofit Work

Nonprofit Policy Forum, 2023
Nonprofit scholars and practitioners alike adhere to a long-held assumption that nonprofit work is, and will remain, inherently meaningful work. The long-term marketization of the nonprofit sector coupled with the influence of the COVID-19 pandemic has ...
Robichau Robbie Waters, Sandberg Billie, Russo Andrew   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Pengaruh Work Meaningfulness Terhadap Intention to Stay di Generasi Z [PDF]

, 2023
Penelitian ini diambil dari mengeksplorasi karakteristik pekerjaan yang bermakna bagi generasi Z dan pengaruhnya terhadap retensi karyawan. Kualitas intrinsik dari karakteristik pekerjaan akan menumbuhkan kebermaknaan pengalaman yang akhirnya ...
Nina Nurhasanah, Pina Dewi Astuti
core   +1 more source

Engagement of employees in a research organisation: A relational perspective

South African Journal of Economic and Management Sciences, 2017
Background: Increasing work engagement in a sustainable way remains a challenge despite years of research on the topic. Relationships at work are vital to foster engagement or disengagement.
Doris Asiwe, Sebastiaan Rothmann, Lene Jorgensen, Carin Hill   +3 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

COVID-19 triggering homecare professionals’ change of attitudes towards e-Welfare

Finnish Journal of eHealth and eWelfare, 2020
During 2020, the COVID-19 crisis expanded the use of digital tools in public health and social care. The aim of this qualitative, single-case study was to scrutinize how homecare professionals experienced meaningfulness in their work in the midst of a ...
Päivikki Kuoppakangas, Juha Lindfors, Jari Stenwall, Tony Kinder, Antti Talonen   +4 more
doaj   +1 more source