Results 41 to 50 of about 503,226 (216)

What difference does it make? A laboratory experiment on the effectiveness of health-oriented leadership working on-site compared to the digital working context

BMC Public Health, 2023
Background Health-oriented leadership (HoL) represents an important workplace resource for employees. However, as opportunities to work from home increase, the question arises, whether leadership is more or less effective in digital working contexts ...
Laura Klebe, Jörg Felfe
doaj   +1 more source

Working from home in Australia during the COVID-19 pandemic: cross-sectional results from the Employees Working From Home (EWFH) study

BMJ Open, 2022
Objectives To investigate the impacts, on mental and physical health, of a mandatory shift to working from home during the COVID-19 pandemic.Design Cross sectional, online survey.Setting Online survey was conducted from September 2020 to November 2020 in
Rwth Stuckey, Jodi Oakman, Natasha Kinsman, Katrina Lambert, Melissa Graham, Victoria Weale   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Working From Home Phenomenon As an Effort to Prevent COVID-19 Attacks and Its Impacts on Work Productivity

TIJAB (The International Journal of Applied Business), 2020
COVID-19 attacks have changed the methods and cultures of work in many organizations, the working from home (WFH) phenomenon as an effort to prevent the spread of COVID-19 in many countries in the world has impacts on employee productivity.
Duta Mustajab, Azies Bauw, Abdul Rasyid, Andri Irawan, Muhammad Aldrin Akbar, Muhammad Amin Hamid   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

When Do Teleworkers Feel both Job-Satisfied and Productive? Boundary Conditions of the Telework Satisfaction-Productivity Relationship

Journal of Work and Organizational Psychology
Recent research suggests that employee well-being plays a key mediating role in transmitting the positive effects of telework on productivity. However, there are circumstances in which employee satisfaction with telework is insufficient for employee ...
Ernesto del Castillo, Sergio Madero, Alexander Lapshun, Juan I. Sanchez   +3 more
doaj   +1 more source

Liquid lives – Blurred boundaries: Working from home and the transport practices of parents

Transportation Research Interdisciplinary Perspectives
In some sectors and settings, the ability to work from home is increasingly common. The way this ability is experienced, and its impact on socio-spatial ordering, is shaped by context.
Jennifer L. Kent, Alexa Delbosc
doaj   +1 more source