Results 201 to 210 of about 6,882,389 (239)
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Behavioural Brain Research, 2020
Pain is a physiological response which is mediated via the central and peripheral nervous system. Betaine, is a methyl glycine derivative and a commonly used nutrient supplement. The main purpose of the current paper is to determine the possible anti-nociceptive and antioxidant activity and sedative effect of betaine in mice.
Seyed mohammad mojtaba Razavi +2 more
exaly +3 more sources
Pain is a physiological response which is mediated via the central and peripheral nervous system. Betaine, is a methyl glycine derivative and a commonly used nutrient supplement. The main purpose of the current paper is to determine the possible anti-nociceptive and antioxidant activity and sedative effect of betaine in mice.
Seyed mohammad mojtaba Razavi +2 more
exaly +3 more sources
Archives of Pharmacal Research, 2010
It has been reported that hypobaric hypoxia exposure by high altitude is responsible for neuropsychological impairment. In the present study, we examined an effect of hypobaric hypoxia on the writhing test. The ICR mice were exposed in hypobaric chamber with several altitudes (5000, 10,000 or 20,000 ft) for 1 or 2 h, and then immediately injected ...
Min-Soo Kwon
exaly +3 more sources
It has been reported that hypobaric hypoxia exposure by high altitude is responsible for neuropsychological impairment. In the present study, we examined an effect of hypobaric hypoxia on the writhing test. The ICR mice were exposed in hypobaric chamber with several altitudes (5000, 10,000 or 20,000 ft) for 1 or 2 h, and then immediately injected ...
Min-Soo Kwon
exaly +3 more sources
Supraspinal and spinal potency of selective opioid agonists in the mouse writhing test.
The Journal of Pharmacology and Experimental Therapeutics, 1987Three agonists with the highest degree of selectivity available for mu ([D-Ala2,NMePhe4,Gly-ol]enkephalin, DAGO), delta ([ D-Pen2,D-Pen5]enkephalin, DPDPE) and kappa (U-50,488H, U50) opioid receptors were compared for their activity in inhibiting acetic acid-induced writhing in mice.
F, Porreca +4 more
openaire +2 more sources
European Journal of Pharmacology, 2006
Some antidepressants, as well as antiepileptics, are effective for treating pain of varying etiology. The present study was designed to characterize the antinociceptive effects of imipramine, a tricyclic antidepressant, fluvoxamine, a selective serotonin reuptake inhibitor, milnacipran, a serotonin noradrenaline reuptake inhibitor, and carbamazepine ...
Minoru Tsuji +2 more
exaly +3 more sources
Some antidepressants, as well as antiepileptics, are effective for treating pain of varying etiology. The present study was designed to characterize the antinociceptive effects of imipramine, a tricyclic antidepressant, fluvoxamine, a selective serotonin reuptake inhibitor, milnacipran, a serotonin noradrenaline reuptake inhibitor, and carbamazepine ...
Minoru Tsuji +2 more
exaly +3 more sources
A test for analgesics: incoordination in writhing mice.
Methods and findings in experimental and clinical pharmacology, 1987Acetic acid administered to mice resulted in post-writhing incoordination and a subsequent fall in the rota-rod test. This fall from rota-rod induced by 3% acetic acid was dose-dependently protected by the non-narcotic analgesics. While suprofen was found to be the most potent (ED50 = 15.29 mg/kg), aspirin was found to be the least potent (ED50 = 81.54
P P, Singh, A Y, Junnarkar, R K, Varma
openaire +1 more source
Interaction of angiotensin II and adenosine A1 and A2A receptor ligands on the writhing test in mice
Pharmacology Biochemistry and Behavior, 2002The effects of adenosine A1 and A2A receptor agonists and antagonists administered intraperitoneally (i.p.) and their interaction with angiotensin II (Ang II) administered intracerebroventricularly (i.c.v.) were studied in mice using the acetic acid-induced abdominal constriction test.
Daniela Marinova, Pechlivanova +1 more
openaire +2 more sources
Synergistic interaction between rilmenidine and ibuprofen in the writhing test in mice.
Neuro endocrinology letters, 2009The aim of the study was to ascertain whether rilmenidine, a second generation imidazoline-alpha-2-adrenoreceptor agonist, is able to increase analgesic effects of ibuprofen in the writhing test in mice. Experimental studies combining these agents have not yet been published.An acetic acid (0.7%) solution was injected into the peritoneal cavity and the
Soukupova M, Dolezal T, Krsiak M
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A test for analgesics as an indicator of locomotor activity in writhing mice.
Archives internationales de pharmacodynamie et de therapie, 1980Marked depression of locomotor activity was observed in writhing mice given acetic acid i.p. This depression of the activity was evidenced by a squatting posture in reaction to pain. The hypoactivity was reversed dose-dependently by nonnarcotic analgesics such as acetyl-salicylic acid, aminopyrine and mefenamic acid in smaller dosages than those ...
T, Harada +3 more
openaire +1 more source
Acetic acid and phenylquinone writhing test: a critical study in mice.
Methods and findings in experimental and clinical pharmacology, 1984Studies were planned to establish the dose-effect relationship with both acetic acid and phenylquinone and to find out suitable concentrations for these two chemicals for pre- and post screening. The LD50 of acetic acid and phenylquinone were found to be 3.16% and 0.23%, respectively.
P P, Singh +4 more
openaire +1 more source
Protein & Peptide Letters, 2009
Diocleinae lectins administered per oral route in mice inhibited the abdominal constrictions induced by acetic acid. The percentage of the lectins antinociception varied from 61% for Canavalia grandiflora (ConGf) to 20% for Dioclea violacea. ConGf inhibited contortions at all doses tested but not in a dose-dependent manner, involving carbohydrate ...
Fernanda R, Holanda +8 more
openaire +2 more sources
Diocleinae lectins administered per oral route in mice inhibited the abdominal constrictions induced by acetic acid. The percentage of the lectins antinociception varied from 61% for Canavalia grandiflora (ConGf) to 20% for Dioclea violacea. ConGf inhibited contortions at all doses tested but not in a dose-dependent manner, involving carbohydrate ...
Fernanda R, Holanda +8 more
openaire +2 more sources