Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The effects of written languaging on new essay writing:a qualitative analysis [PDF]
According to Swain(2006), providing learners with the opportunity to language about or reflect on their developing linguistic knowledge in the course of L2 learning mediates L2 learning and development.
SUZUKI Wataru
core +1 more source
Feedback Given By The Teacher On Students' Writing At The Seventh Grade Of Smp Negeri 2 Juwiring [PDF]
The objectives of the study are to describe the types of teacher’s feedback on the students’ writing at the seventh grade of SMP Negeri 2 Juwiring and the students’ responses toward the teacher’s feedback.
, Mauly Halwat Hikmat, Ph.D +1 more
core
A model of factors affecting independent learners’ engagement with feedback on language learning tasks [PDF]
In independent learning contexts, the effectiveness of the feedback dialogue between student and tutor or, in the absence of a tutor, the quality of the learning materials, is essential to successful learning.
Fernández-Toro, Maria, Hurd, Stella
core +1 more source
Grammatical Accuracy using Teacher’s Written Corrective Feedback
The purpose of this research was to improve grammatical accuracy on writing descriptive text by using Teacher’s Written Corrective Feedback and to know their perceptions toward the application of the technique in teaching writing. This research design was a classroom action research that was conducted collaboratively with the English teacher.
Solfiyatuzzahro Solfiyatuzzahro +2 more
openaire +2 more sources
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
College students’ preferences for written corrective feedback
Although written corrective feedback (WCF) is provided to give students information about their writing which intends to help them make improvement, students may have different expectations of how WCF should be delivered. This study was focused on investigating English Language Education (ELE) students’ preferences for the WCF covering the preferences ...
Nova Ariani +2 more
openaire +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source

