Results 91 to 100 of about 20,035 (219)
Mouse models of ageing and their relevance to disease [PDF]
, 2016 Ageing is a process that gradually increases the organism’s vulnerability to death. It affects different biological pathways, and the underlying cellular mechanisms are complex.
Dogan, Soner +5 more
core +2 more sources
Dietary Overlap of Sympatric Polyphagous Alpine Grasshoppers Includes Invasive Plant Species
Ecology and Evolution, Volume 16, Issue 5, May 2026.The diets of three sympatric grasshopper species were compared using mandible morphological analysis, microhistological examination, and DNA metabarcoding of gut contents. Although mandible morphology differed across species and sexes, dietary divergence was not evident.
Mari Nakano +3 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 2005 Werner syndrome (WS) is a premature aging disease caused by a mutation in the WRN gene. The gene was identified in 1996 and its product acts as a DNA helicase and exonuclease. Some specific WRN polymorphic variants were associated with increased risk for
M.A.C. Smith +9 more
doaj +1 more source
Characterization of Stress Responses in a Drosophila Model of Werner Syndrome
Biomolecules, 2021 As organisms age, their resistance to stress decreases while their risk of disease increases. This can be shown in patients with Werner syndrome (WS), which is a genetic disease characterized by accelerated aging along with increased risk of cancer and ...
Derek G. Epiney +8 more
doaj +1 more source
Long-term culture captures injury-repair cycles of colonic stem cells [PDF]
, 2019 The colonic epithelium can undergo multiple rounds of damage and repair, often in response to excessive inflammation. The responsive stem cell that mediates this process is unclear, in part because of a lack of in vitro models that recapitulate key ...
Chen, Feidi +19 more
core +1 more source
Functional regulation of FEN1 nuclease and its link to cancer [PDF]
, 2011 Flap endonuclease-1 (FEN1) is a member of the Rad2 structure-specific nuclease family. FEN1 possesses FEN, 5′-exonuclease and gap-endonuclease activities. The multiple nuclease activities of FEN1 allow it to participate in numerous DNA metabolic pathways,
Finger, L.D. +5 more
core +1 more source
Molecular pathology of phyllodes tumours of the breast—much more than MED12
Histopathology, Volume 88, Issue 6, Page 1115-1125, May 2026.Phyllodes tumours can develop from fibroadenomas bearing MED12 variants by the development of pTERT alterations (“MED12 pathway”) or de novo (“MED12 independent pathway”). Grade progression is associated with increasing genetic complexity including cancer driver gene aberrations. Molecular alterations can be useful in assigning grade and distinguishing
Jia‐Min B Pang +3 more
wiley +1 more source
Improvement of heart rate recovery after exercise training in older people. [PDF]
, 2005 Twenty-four subjects aged 70 and older were retrospectively selected from our archives and screened for symptoms of cardiovascular disease. Baseline exercise test was negative for myocardial ischemia in all subjects.
De Lorenzo A. +6 more
core +1 more source
Food Science &Nutrition, Volume 14, Issue 4, April 2026.In 4976 U.S. adults from NHANES 2011–2020, dietary factors influenced urinary volatile organic compound metabolites (VOCMs) and modified their associations with multi‐dimensional biological aging. Multiple VOCMs were positively associated with biological age indicators, with KDMAgeAccel being the most sensitive marker.
Weitao Su +10 more
wiley +1 more source
Breast Cancer Research, 2021 Background NRG1 gene fusions may be clinically actionable, since cancers carrying the fusion transcripts can be sensitive to tyrosine kinase inhibitors.
Karen D. Howarth +12 more
doaj +1 more source