Results 111 to 120 of about 20,035 (219)
Advanced Science, Volume 13, Issue 13, 3 March 2026.Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang +10 more
wiley +1 more source
Early diagnosis of Werner’s syndrome using exome-wide sequencing in a single, atypical patient
Frontiers in Endocrinology, 2011 Genetic diagnosis of inherited metabolic disease is conventionally achieved through syndrome recognition and targeted gene sequencing, but many patients receive no specific diagnosis.
Eleanor eRaffan +18 more
doaj +1 more source
Advanced Science, Volume 13, Issue 18, 27 March 2026.In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang +15 more
wiley +1 more source
Clinicopathological and functional significance of RECQL1 helicase in sporadic breast cancers [PDF]
, 2017 RECQL1, a key member of the RecQ family of DNA helicases, is required for DNA replication and DNA repair. Two recent studies have shown that germline RECQL1 mutations are associated with increased breast cancer susceptibility.
Andrew R. Green +22 more
core +2 more sources
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Modeling Polymeric Drug Release: The Emerging Role of Machine Learning
WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.A review of mechanistic, empirical, and machine learning (ML) approaches for modeling drug release from polymeric systems, highlighting how data‐driven methods uncover relationships between formulation parameters and release behavior to guide future drug delivery design.
Ryan N. Woodring, Kristy M. Ainslie
wiley +1 more source
Stem Cell Research, 2019 Werner syndrome (WS) is a rare human autosomal recessive disorder characterized by early onset of aging-associated diseases, chromosomal instability, and cancer predisposition, without therapeutic treatment solution. Major clinical symptoms of WS include
Vincent Gatinois +7 more
doaj +1 more source
Clinical Genetics, Volume 109, Issue 3, Page 458-469, March 2026.Whole‐exome sequencing of five families with non‐medullary thyroid cancer revealed three candidate genes. Functional analyses confirmed BCL2L11 as a strong candidate gene for hereditary predisposition to non‐medullary thyroid cancer. ABSTRACT Familial non‐medullary thyroid cancer, defined as two or more affected first‐degree relatives, accounts for 3 ...
Duygu Abbasoglu +9 more
wiley +1 more source
The Heli-CASE of the Missing WRN Gene [PDF]
Werner Syndrome is an autosomal recessive disease characterized by genomic instability, accelerated telomere shortening, and premature aging. Also, Werner Syndrome patients experience increased cancer rates, believed to be directly related to the lack of
Jeziorny, Lisa +4 more
core +1 more source
A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. [PDF]
, 2016 In mammals the regulation of genomic instability plays a key role in tumor suppression and also controls genome plasticity, which is important for recombination during the processes of immunity and meiosis.
Adams, David J +12 more
core +6 more sources