Results 121 to 130 of about 20,035 (219)

Supplementary Table 1A from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency [PDF]

, 2023
Russell Moser, Masafumi Toyoshima, Kristin Robinson, Kay E. Gurley, Heather L. Howie, Jerry Davison, Martin Morgan, Christopher J. Kemp, Carla Grandori   +8 more
openalex   +2 more sources

RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner [PDF]

, 2017
Sensitivity of cancer cells to DNA damaging chemotherapeutics is determined by DNA repair processes. Consequently, cancer cells may upregulate the expression of certain DNA repair genes as a mechanism to promote chemoresistance.
Abbruzzese, Berger, Biasin, Blackshear, Blandino, Bohr, Bohr, Bohr, Bohr, Brosh, Brosh, Brosh, Brosh, Brosh, Brosh, Byrski, Chen, Chinnaiyan, Constantinou, Del Sal, Dianov, Furuichi, Furuichi, Furuichi, Furuichi, Goldberg, Goto, Harris, Helleday, Helleday, Helleday, Hickson, Jacks, Jackson, Kaina, Kaina, Kaina, Kufe, Lamond, Larocque, Lees-Miller, Madhusudan, Maloney, Messeguer, Moreaux, Ohnishi, Okabe, Resnick, Resnick, Roy, Serrano, Sharma, Sharma, Sharma, Sharma, Sharma, Sharma, Sharma, Sharma, Szallasi, Vindigni, Vogelstein, Vogelstein, Vogelstein, von Mering, Vousden, Xie, Yano   +67 more
core   +2 more sources

Selection on Codon Usage for Error Minimization at the Protein Level [PDF]

, 2018
Given the structure of the genetic code, synonymous codons differ in their capacity to minimize the effects of errors due to mutation or mistranslation.
Archetti, Marco
core  

Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities

Genome Medicine
Background Loss-of-function (LOF) alterations in tumour suppressor genes cannot be directly targeted. Approaches characterising gene function and vulnerabilities conferred by such mutations are required.
Yuka Takemon, Erin D. Pleasance, Alessia Gagliardi, Christopher S. Hughes, Veronika Csizmok, Kathleen Wee, Diane L. Trinh, Ryan D. Huff, Andrew J. Mungall, Richard A. Moore, Eric Chuah, Karen L. Mungall, Eleanor Lewis, Jessica Nelson, Howard J. Lim, Daniel J. Renouf, Steven JM. Jones, Janessa Laskin, Marco A. Marra   +18 more
doaj   +1 more source

Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression

Cell Reports, 2015
Nucleotide pool imbalance has been proposed to drive genetic instability in cancer. Here, we show that slowing replication forks by depleting nucleotide pools with hydroxyurea (HU) can also give rise to both transient and permanent epigenetic instability
Charikleia Papadopoulou, Guillaume Guilbaud, Davide Schiavone, Julian E. Sale   +3 more
doaj   +1 more source

Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming

Frontiers in Genetics, 2015
Werner syndrome (WS) is a rare human autosomal recessive premature aging disorder characterized by early onset of aging-associated diseases, chromosomal instability, and cancer predisposition.
Akira eShimamoto, Koutaro eYokote, Hidetoshi eTahara   +2 more
doaj   +1 more source

Werner Syndrome Caused by Homozygous Frameshift Variant c.1578del in WRN

Acta Medica Lituanica
Background. Progerias are rare hereditary genetic disorders that cause the onset of aging to occur earlier than generally expected, which initiates the progression of many age-related diseases.
Jovita Patricija Druta, Gunda Petraitytė, Aušra Sasnauskienė, Eglė Preikšaitienė   +3 more
doaj   +1 more source

Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype

BMC Genetics, 2001
Background Genomic instability has been reported at microsatellite tracts in few coding sequences. We have shown that the Bloom syndrome BLM gene may be a target of microsatelliteinstability (MSI) in a short poly-adenine repeat located in its coding ...
Matei Irina, Herlea Vlad, Ranzani Guglielmina N, Amadori Dino, Calin George, Barbanti-Brodano Giuseppe, Negrini Massimo   +6 more
doaj   +1 more source

Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]

, 2012
Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
core  

Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage [PDF]

, 2017
Reactive oxygen species constantly generated as by-products of cellular metabolism readily attack genomic DNA creating mutagenic lesions such as 7,8-dihydro-8-oxo-guanine (8-oxo-G) that promote aging. 8-oxo-G:A mispairs arising during DNA replication are
Bohr, Vilhelm A., Burdova, Kamila, Furrer, Antonia, Hübscher, Ulrich, Janscak, Pavel, Kanagaraj, Radhakrishnan, König, Christiane, Mihaljevic, Boris, Parasuraman, Prasanna, van Loon, Barbara   +9 more
core