Results 61 to 70 of about 20,035 (219)
Human RecQ Helicases in DNA Double-Strand Break Repair
Frontiers in Cell and Developmental Biology, 2021 RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and animals. These helicases play important roles in multiple cellular functions, including DNA replication, transcription, DNA repair, and telomere maintenance.
Huiming Lu, Anthony J. Davis
doaj +1 more source
Genomic aberrations in lung adenocarcinoma in never smokers. [PDF]
PLoS ONE, 2010 BACKGROUND: Lung cancer in never smokers would rank as the seventh most common cause of cancer death worldwide. METHODS AND FINDINGS: We performed high-resolution array comparative genomic hybridization analysis of lung adenocarcinoma in sixty never ...
Bastien Job +12 more
doaj +1 more source
Emerging roles of telomeric chromatin alterations in cancer [PDF]
, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria +2 more
core +1 more source
Journal of Hematology & Oncology, 2016 Background Human T-cell leukemia virus type 1 (HTLV-1) infection is associated with adult T-cell leukemia/lymphoma (ATLL), a lymphoproliferative malignancy with a dismal prognosis and limited therapeutic options.
R. Moles +3 more
doaj +1 more source
Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells [PDF]
, 2015 This research was originally published in Journal of Biological Chemistry. Olesya Chayka, Cosimo Walter D’Acunto, Odette Middleton, Maryam Arab, and Arturo Sala.
Arab, M +4 more
core +1 more source
Genetic Variation in the Premature Aging Gene WRN: A Case-Control Study on Breast Cancer Susceptibility [PDF]
Cancer Epidemiology, Biomarkers & Prevention, 2007 Abstract The high risk of developing cancer seen in human genetic diseases that resemble accelerated aging provides support for a tumorigenic contribution of the mechanisms and genes responsible for regulating life span and aging. We therefore speculated that the WRN gene (encoding RECQL2, a DNA helicase), the germline mutation of which ...
Shian-ling, Ding +4 more
openaire +2 more sources
Hereditary Cancer in Clinical Practice, 2023 Background Synchronous endometrial and ovarian cancer (SEOC) accounts for 50–70% of all synchronous gynecology cancers in women. Approximately 14% of SEOC cases are caused by Lynch syndrome (LS). The widespread introduction of “universal screening” at LS
Zornitsa Bogomilova Kamburova +5 more
doaj +1 more source
Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium [PDF]
, 2017 Adaptive cellular responses are often required during wound repair. Following disruption of the intestinal epithelium, wound‐associated epithelial (WAE) cells form the initial barrier over the wound.
Lai, Chin-Wen +7 more
core +2 more sources
Std fimbriae-fucose interaction increases Salmonella-induced intestinal inflammation and prolongs colonization [PDF]
, 2019 Author summary The intestinal epithelium is a crucial biological interface, interacting with both commensal and pathogenic microorganisms. It’s lined with heavily glycosylated proteins and glycolipids which can act as both attachment sites and energy ...
Baines, J. +12 more
core +1 more source
Accelerated epigenetic aging in Werner syndrome. [PDF]
, 2017 Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased ...
Flunkert, Julia +5 more
core +1 more source