Results 51 to 60 of about 20,035 (219)

Duplex DNA from Sites of Helicase-Polymerase Uncoupling Links Non-B DNA Structure Formation to Replicative Stress [PDF]

, 2020
BACKGROUND: Replication impediments can produce helicase-polymerase uncoupling allowing lagging strand synthesis to continue for as much as 6 kb from the site of the impediment.
Abdelhamid, Mahmoud A S, Amparo, Camille, Bedell, Victoria, Clark, Jarrod, Martella, Marianna, Murata-Collins, Joyce L, Pichiorri, Flavia, Smith, Steven S, Waller, Zoë A E, Warner, Emily F   +9 more
core   +2 more sources

WRN polymorphisms affect expression levels of plasminogen activator inhibitor type 1 in cultured fibroblasts

BMC Cardiovascular Disorders, 2008
Background Recessive mutations in WRN gene eliminate WRN protein function (helicase) and cause Werner syndrome. One of the most important clinical features of Werner syndrome patients are the premature onset and accelerated atherosclerosis process ...
Oviedo-Rodríguez Vladimir, Castro Elena, Angel-Chávez Luis I   +2 more
doaj   +1 more source

Low-Level Mouse DNA in Conditioned Medium Generates False Positive Cross-Species Contamination Results in Human Organoid Cultures

Frontiers in Cell and Developmental Biology, 2020
Cell line authentication is critical for preventing the use of mixed or misidentified cell lines in research. Current efforts include short tandem repeat (STR) analysis and PCR-based assays to detect mixed species cultures.
Margaret S. Bohm, Michael K. Dame, Joseph Boyd, Kevin Su, Angeline Wu, Durga Attili, Vi Chu, Justin A. Colacino, Justin A. Colacino, Justin A. Colacino, Jason R. Spence, Jason R. Spence, Jason R. Spence   +12 more
doaj   +1 more source

Werner syndrome presenting as early‐onset diabetes: A case report

Journal of Diabetes Investigation, 2022
Werner syndrome is a rare autosomal recessive premature progeroid syndrome caused by mutations in the WRN gene. It is characterized by early onset of age‐related diseases, such as cataracts, atherosclerosis, diabetes mellitus, osteoporosis and ...
Xiaoli Wang, Siruo Liu, Fengye Qin, Qian Liu, Qiuyue Wang   +4 more
doaj   +1 more source

ruvA Mutants that resolve Holliday junctions but do not reverse replication forks [PDF]

, 2008
RuvAB and RuvABC complexes catalyze branch migration and resolution of Holliday junctions (HJs) respectively. In addition to their action in the last steps of homologous recombination, they process HJs made by replication fork reversal, a reaction which ...
A Blastyak, A Constantinou, A Kuzminov, A Machwe, Alison Sylvia Bradley, B Guenther, B Michel, B Michel, Bénédicte Michel, C Ralf, CA Parsons, CE Shurvinton, CV Privezentzev, CZ Bachrati, D Chamberlain, D Hargreaves, DV Bugreev, EC Friedberg, EP Rocha, F Lecointe, F Osman, F Osman, G Grompone, H Iwasaki, H Shinagawa, IR Tsaneva, IR Tsaneva, Irina Tsaneva, JB Rafferty, JH Miller, JK Karow, JR Donaldson, K Hiom, K Yamada, K Yamada, L Wu, M Ariyoshi, M Fromant, M Lopes, M Oram, M Seigneur, Marie Le Masson, MC Whitby, MC Whitby, ME Robu, MJ Flores, P McGlynn, P McGlynn, P McGlynn, P McGlynn, R Lestini, RC Heller, RG Lloyd, SC West, SD Vincent, SM Roe, SN Chan, T Hishida, T Hishida, T Nishino, T Nishino, T Shibata, TN Mandal, W Bussen, William F. Burkholder, Y Liu, Y Liu, Z Baharoglu, Zeynep Baharoglu   +68 more
core   +3 more sources

Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion

Journal of Nucleic Acids, 2010
Werner syndrome is a rare disorder that manifests as premature aging and age-related diseases. WRN is the gene mutated in WS, and is one of five human RecQ helicase family members.
Adam D. Brown, Alison B. Claybon, Alexander J. R. Bishop   +2 more
doaj   +1 more source

C. elegans orthologs MUT-7/CeWRN-1 of Werner syndrome protein regulate neuronal plasticity

eLife, 2021
Caenorhabditis elegans expresses human Werner syndrome protein (WRN) orthologs as two distinct proteins: MUT-7, with a 3′−5′ exonuclease domain, and CeWRN-1, with helicase domains. How these domains cooperate remains unclear.
Tsung-Yuan Hsu, Bo Zhang, Noelle D L'Etoile, Bi-Tzen Juang   +3 more
doaj   +1 more source

DNA repair: Disorders [PDF]

, 2010
No description ...
Bose, Burg, Caldecott, Chu, Digweed, Fernandez-Capetillo, Fousteri, Fousteri, Friedberg, Gudmundsdottir, Hashimoto, Hoeijmakers, Jiricny, Kraemer, Lavin, Lehmann, Lieber, Ma, Masutani, McCulloch, Meindl, Moldovan, Moshous, Nance, Nouspikel, O'Driscoll, O'Driscoll, O'Driscoll, O'Driscoll, Rass, Stefanini, Stewart, Stracker, Taylor, Vaz, Wu, Zlatanou   +36 more
core   +1 more source

A scalable saliency-based Feature selection method with instance level information [PDF]

, 2019
Classic feature selection techniques remove those features that are either irrelevant or redundant, achieving a subset of relevant features that help to provide a better knowledge extraction.
Alonso-Betanzos, Amparo, Bolón-Canedo, Verónica, Cancela, Brais, Gama, João   +3 more
core   +2 more sources

Allelic interaction effects of DNA damage and repair genes on the predisposition to age-related cataract. [PDF]

PLoS ONE, 2018
Age-related cataract (ARC) is a leading cause of visual impairment and blindness worldwide. DNA damage and malfunction of DNA repair are believed to contribute to the pathogenesis of ARC.
Mei Yang, Junfang Zhang, Shu Su, Bai Qin, Lihua Kang, Rongrong Zhu, Huaijin Guan   +6 more
doaj   +1 more source