Esophageal Cancer Risk is Associated with Polymorphisms of DNA Repair Genes MSH2 and WRN in Chinese Population [PDF]
Journal of Thoracic Oncology, 2011 Normal function of DNA repair system is essential for the removal of damage induced by many kinds of internal and environmental agents. Genetic polymorphisms in DNA repair genes associated with modified repair capacity may be related to the risk of developing esophageal cancer (EC).
Ting Li +6 more
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Werner Syndrome Helicase (WRN) Gene Variants and Cancer in Japanese Elderly: An Autopsy Study [PDF]
Journal of Geriatric Medicine and Gerontology, 2020 Zong Yuan +3 more
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Cancer Science, 2008 Bone and soft tissue sarcomas (BSTSs) are rare malignant tumors of mesenchymal origin. Although BSTSs frequently occur in some hereditary cancer syndromes with germline mutations of DNA repair genes, genetic factors responsible for sporadic cases have not been determined.
Robert Nakayama +15 more
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Efficacy and safety of SGLT2 inhibitor on insulin resistance and hyperglycemia in Werner syndrome—A case report [PDF]
Journal of Diabetes InvestigationA 48‐year‐old man was referred to our hospital due to hyperglycemia. His casual plasma glucose and glycated hemoglobin A1c were 25.2 mmol/L and 8.7%, respectively. He had undergone bilateral cataract surgery in his 30s.
Takashi Yagi +7 more
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A new Caenorhabditis elegans apurinic/apyrimidinic (AP) endonuclease engaged in rescue from replication stress-induced arrest [PDF]
Genetics and Molecular BiologyApurinic/apyrimidinic sites are one of the most frequent spontaneous lesions in DNA. Evolutionarily conserved AP endonucleases (ExoIII and EndoIV families) incise the DNA backbone 5′ to the AP site and the cleaved AP sites are subsequently repaired by ...
Seoyun Choi, Hoa Thi Pham, Byungchan Ahn
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Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A
Scientific Reports, 2021 Werner syndrome (WRN) is a rare progressive genetic disorder, caused by functional defects in WRN protein and RecQ4L DNA helicase. Acceleration of the aging process is initiated at puberty and the expected life span is approximately the late 50 s ...
So-mi Kang +11 more
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Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells
Cell & Bioscience, 2022 Background Pathogenic mutations in WRN are a cause of premature aging disease Werner syndrome (WS). Besides accelerated aging phenotypes and cancer predisposition, patients with WS also display underdevelopment in the skeletal system, characterized by ...
Adrian On-Wah Leung +7 more
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Stem Cell Research, 2021 Adult progeria Werner syndrome (WS), a rare autosomal recessive disorder, is characterized by accelerated aging symptoms after puberty. The causative gene, WRN, is a member of the RecQ DNA helicase family and is predominantly involved in DNA replication,
Hisaya Kato +17 more
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WRN, the Werner Syndrome Gene, Exhibits Frameshift Mutations in Gastric and Colorectal Cancers
Pathology & Oncology Research, 2016 Ju Hwa Lee +4 more
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Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein. [PDF]
PLoS ONE, 2018 Werner syndrome (WS) is a premature aging disorder caused by mutations in a protein containing both a DNA exonuclease and DNA helicase domain. Mice lacking the helicase domain of the Wrn protein orthologue exhibit transcriptomic and metabolic alterations,
Lucie Aumailley +4 more
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