Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation [PDF]
Nucleic Acids Research, 2002 A gene encoding a new member of the Pur protein family, Purgamma, has been detected upstream of, and contrapodal to, the gene encoding the Werner syndrome helicase, Wrn, at human chromosome band 8p11-12. Both the PURG and WRN genes initiate transcription at multiple sites, the major clusters of which are approximately 90 bp apart.
Hong Liu
exaly +5 more sources
Supplementary Figure 2 from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency [PDF]
, 2023 <p>PDF file - 164K</p>
Russell Moser +8 more
+4 more sources
Supplementary Figure 4 from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency [PDF]
, 2023 <p>PDF file - 114K</p>
Russell Moser +8 more
+4 more sources
Colorectal cancer and polymorphisms in DNA repair genes WRN , RMI1 and BLM [PDF]
Carcinogenesis, 2009 RecQ helicase family members are involved in multiple DNA repair pathways, protecting the genome from incorrect recombination during mitosis and maintaining its stability. Deficiencies in genes encoding the RecQ helicases WRN and BLM lead to rare autosomal recessive diseases, Werner and Bloom syndromes, which have been implicated in early onset of ...
Bernd Frank +5 more
openalex +3 more sources
Supplementary Figure Legends 1-5, Table Legend 1 from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency [PDF]
, 2023 <p>PDF file - 100K</p>
Russell Moser +8 more
+4 more sources
Premature aging syndrome gene WRN genetically interacts with a topoisomerase [PDF]
Cell Cycle, 2009 Comment on: WRN helicase defective in the premature aging disorder Werner Syndrome genetically interacts with topoisomerase 3 and restores the top3 slowgrowth phenotype of sgs1 top3. Monika Aggarwal, Robert M. Brosh, Jr.
Monika Aggarwal, Robert M. Brosh
openalex +2 more sources
Supplementary Figure 1 from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency [PDF]
, 2023 <p>PDF file - 112K</p>
Russell Moser +8 more
+4 more sources
L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams [PDF]
Stem Cell Research, 2019 Conditioned medium (CM) derived from engineered cells often facilitates the cost-effective culture of a variety of stem cells. Growing emphasis on the importance of rigor and reproducibility in lab-based science requires development of best practices ...
Kelli L. VanDussen +2 more
doaj +3 more sources
Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background [PDF]
Molecular and Cellular Biology, 2000 Werner's syndrome (WS) is a human disease with manifestations resembling premature aging. The gene defective in WS, WRN, encodes a DNA helicase. Here, we describe the generation of mice bearing a mutation that eliminates expression of the C terminus of the helicase domain of the WRN protein.
David B. Lombard +11 more
openalex +4 more sources
Cellular Werner Phenotypes in Mice Expressing a Putative Dominant-Negative Human WRN Gene [PDF]
Genetics, 2000 Abstract Mutations at the Werner helicase locus (WRN) are responsible for the Werner syndrome (WS). WS patients prematurely develop an aged appearance and various age-related disorders. We have generated transgenic mice expressing human WRN with a putative dominant-negative mutation (K577M-WRN).
Lan Wang +6 more
openalex +3 more sources