Sclerosing epithelioid fibrosarcoma associated with WRN gene variant presenting as chronic dyspnea and pathologic cervical fracture: a case report and review of the literature [PDF]
Journal of Medical Case Reports, 2023 Background Sclerosing epithelioid fibrosarcoma is an aggressive sarcoma subtype with poor prognosis and limited response to conventional chemotherapy regimens.
Alexander T. Phan +7 more
doaj +6 more sources
Recurrent skin ulcer cross-repair and sensory reconstruction in a WRN gene mutational patient [PDF]
Anais Brasileiros de Dermatologia, 2018 : A 37-year-old man complained of a refractory posterior malleolar ulceration on his left ankle. He was diagnosed with Werner syndrome according to the progeroid clinical features and genetic testing. To approach the ulceration, a free flow-through right
Jiqiang He +3 more
doaj +7 more sources
Exacerbated Renal and Hematologic Toxicities to Ifosfamide and Doxorubicin-Based Chemotherapy in a Patient with Retroperitoneal Liposarcoma Harboring a Germline Mutation in the WRN Gene [PDF]
Case Reports in Oncology, 2022 Werner’s syndrome is caused by the inactivation of both WRN alleles and is characterized by premature aging and increased risk of neoplasms, especially those of mesenchymal origins, such as sarcomas. Given the characteristic genomic instability, patients
Beatriz Mendes Awni +9 more
doaj +6 more sources
Whole Exome Sequencing Identifies a Novel Frameshift Mutation of the WRN Gene in a Werner Syndrome Family and Functional Analysis [PDF]
Molecular Genetics & Genomic MedicineIntroduction Werner syndrome (WS) is a rare recessive disorder characterized by premature aging and metabolic abnormalities. WS is caused by mutations in the WS RecQ‐like helicase gene (WRN), which encodes the WRN RecQ‐like helicase protein.
Hao Xiong +7 more
doaj +5 more sources
Adult progeria: a new mutation in the WRN gene. [PDF]
BMJ Case Rep, 2022 Werner syndrome (WS), also known as adult progeria, is a rare autosomal recessive inherited progeroid syndrome characterised by multiple features consistent with accelerated ageing. This disease is associated with several rheumatic conditions such as early osteoarthritis and osteoporosis, sarcopenia, soft-tissue calcifications, gout, limb ulcers and ...
Rocha ML +3 more
europepmc +5 more sources
Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells. [PDF]
Oncol Rep, 2012 The Werner (WRN) gene codes for a DNA helicase that contributes to genomic stability and has been identified as the gene responsible for progeria. Recent studies have shown reduced WRN expression due to aberrant DNA hypermethylation in cancer cells. Furthermore, WRN expression is thought to affect sensitivity
Masuda K +11 more
europepmc +6 more sources
Data from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency
, 2023 <div>Abstract<p>MYC-induced DNA damage is exacerbated in WRN-deficient cells, leading to replication stress and accelerated cellular senescence. To determine whether WRN deficiency impairs MYC-driven tumor development, we used both xenograft and autochthonous tumor models.
Russell Moser +8 more
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MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency [PDF]
Molecular Cancer Research, 2012 Abstract MYC-induced DNA damage is exacerbated in WRN-deficient cells, leading to replication stress and accelerated cellular senescence. To determine whether WRN deficiency impairs MYC-driven tumor development, we used both xenograft and autochthonous tumor models.
Russell Moser +8 more
openalex +4 more sources
Supplementary Table 1B from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency [PDF]
, 2023 <p>PDF file - 5.8MB</p>
Russell Moser +8 more
+4 more sources
Supplementary Figure 5 from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency [PDF]
, 2023 <p>PDF file - 101K</p>
Russell Moser +8 more
+4 more sources