Supplementary Figure 3 from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency [PDF]
, 2023 <p>PDF file - 502K</p>
Russell Moser +8 more
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A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype. [PDF]
PLoS ONE, 2013 Our previous studies demonstrated that Wnt/GSK-3/β-catenin and mTOR signaling are necessary to stimulate proliferative processes in adult human β-cells.
Haytham Aly +7 more
doaj +5 more sources
Putative G-quadruplex forming sequence signatures in genes differentially transcribed upon loss of BLM or WRN helicases [PDF]
, 2015 ABSTRACTPutative G-quadruplex-forming sequences (PQS) have long been implicated in regulation of DNA replication and transcription, though their actual roles are unknown. To gain insight into potential PQS transcriptional function, we map and analyze PQS motifs in promoters of genes differentially-expressed in Bloom Syndrome (BS) and Werner Syndrome ...
John Smestad, L. James Maher
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Aging Is Accompanied by a Progressive Decrease of Expression of the WRN Gene in Human Blood Mononuclear Cells [PDF]
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2010 The WRN gene encodes DNA helicase participating in genome maintenance. We looked for associations of natural aging with expression and methylation of this gene in blood mononuclear cells and with its common polymorphisms. Analyses were performed in ethnically homogenous Polish Caucasians.
Jacek Połosak +4 more
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Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population [PDF]
AGE, 2013 Werner syndrome is caused by mutations in the DNA repair Werner helicase (WRN) gene and characterized by accelerated aging including cataracts. Age-related cataract (ARC) cases (N = 504) and controls (N = 244) were recruited from a population-based study to evaluate the association of single-nucleotide polymorphisms (SNPs) of WRN and another DNA repair
Shengqun Jiang +6 more
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WRN participates in translesion synthesis pathway through interaction with NBS1. [PDF]
Mechanisms of Ageing and Development, 2010 Werner syndrome (WS), caused by mutation of the WRN gene, is an autosomal recessive disorder associated with premature aging and predisposition to cancer.
Asaithamby, Aroumougame +8 more
core +3 more sources
Werner syndrome and mutations of theWRNandLMNAgenes in France [PDF]
Human Mutation, 2006 Werner syndrome (WS) is a pleiotropic disease of premature aging involving short stature, tight, atrophied, and/or ulcerated skin; a characteristic 'birdlike' facies and high, squeaky or hoarse voice; premature greying and thinning of the hair; and early onset cataracts.
Nancy Uhrhammer +8 more
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Werner syndrome exonuclease promotes gut regeneration and causes age-associated gut hyperplasia in Drosophila. [PDF]
PLoS BiologyHuman Werner syndrome (adult progeria, a well-established model of human aging) is caused by mutations in the Werner syndrome (WRN) gene. However, the expression patterns and functions of WRN in natural aging remain poorly understood.
Kun Wu +15 more
doaj +2 more sources
Journal of Bone and Mineral Metabolism, 2001 Werner syndrome (WS) is a rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders. The gene responsible for WS has been identified as WRN, a member of the RecQ family of helicase genes. Based on the fact that patients with WS exhibit osteoporosis and osteoarthritis, the present study was ...
Naoshi Ogata +5 more
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