Results 41 to 50 of about 20,035 (219)

Case Report: A novel WRN mutation in Werner syndrome patient with diabetic foot disease and myelodysplastic syndrome

Frontiers in Endocrinology, 2022
Werner syndrome is an autosomal recessive rare disease caused by a WRN gene mutation, which is rarely reported in the Chinese population. We report the clinical and genetic data of a Chinese patient with Werner syndrome.
Huifang Peng, Jie Wang, Yanyun Liu, Haiping Yang, Liping Li, Yujin Ma, Huiqin Zhuo, Hongwei Jiang   +7 more
doaj   +1 more source

WRN inhibits oxidative stress-induced apoptosis of human lensepithelial cells through ATM/p53 signaling pathway and its expression is downregulated by DNA methylation

Molecular Medicine, 2020
Background Apoptosis and oxidative stress are the main etiology of age related cataract (ARC). This article aims to investigate the role of WRN in lens epithelial cells (LECs).
Shengqun Jiang, Jiansu Chen
doaj   +1 more source

Culture of rabbit caecum organoids by reconstituting the intestinal stem cell niche in vitro with pharmacological inhibitors or L-WRN conditioned medium

Stem Cell Research, 2020
Intestinal organoids are self-organized 3-dimensional (3D) structures formed by a single layer of polarized epithelial cells. This innovative in vitro model is highly relevant to study physiology of the intestinal epithelium and its role in nutrition and
Eloïse Mussard, Cécile Pouzet, Virginie Helies, Géraldine Pascal, Sandra Fourre, Claire Cherbuy, Aude Rubio, Nathalie Vergnolle, Sylvie Combes, Martin Beaumont   +9 more
doaj   +1 more source

The Expression Levels of XLF and Mutant P53 Are Inversely Correlated in Head and Neck Cancer Cells. [PDF]

, 2016
XRCC4-like factor (XLF), also known as Cernunnos, is a protein encoded by the human NHEJ1 gene and an important repair factor for DNA double-strand breaks.
Chen, Wei, Feng, Sizhe, Guo, Mian, Hu, Shen, Liang, Guobiao, Messadi, Diana, Rabii, Ramin, Song, Chenxi, Wei, Xuezhong   +8 more
core   +2 more sources

MUT-7 Provides Molecular Insight into the Werner Syndrome Exonuclease

Cells, 2021
Werner syndrome (WS) is a rare recessive genetic disease characterized by premature aging. Individuals with this disorder develop normally during childhood, but their physiological conditions exacerbate the aging process in late adolescence. WS is caused
Tsung-Yuan Hsu, Ling-Nung Hsu, Shih-Yu Chen, Bi-Tzen Juang   +3 more
doaj   +1 more source

Arabidopsis RecQl4A suppresses homologous recombination and modulates DNA damage responses [PDF]

, 2005
The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood.
Bachrati, Bagherieh-Najjar, Bai, Blackburn, Bundock, Cohen, Courcelle, Cromie, De Silva, Dellaporta, Ellis, Fitzgerald, Frei, Gallego, Gallego, Gallego, Gherbi, Gray, Hanada, Hanin, Harrigan, Hartung, Henson, Imamura, Jackson, Jacques Hille, Johnson, Kitao, Krysan, Li, Lovett, Lowndes, McGlynn, McHugh, Mengiste, Michel, Mohammad B. Bagherieh-Najjar, Nakayama, Nakayama, Nugent, Onno M.H. Vries, Osborn, Pastink, Paul P. Dijkwel, Pierce, Puchta, Reiss, Riha, Riha, Rothstein, Sambrook, Seigneur, Sengupta, Sessions, Simon, Sinclair, Sladek, Sundaresan, Swoboda, Tercero, Ui, Valvekens, Watt, Wu, Yamagata   +64 more
core   +3 more sources

A Case of Werner Syndrome with Compound Heterozygous Mutations of <i>WRN</i> Gene.

Nihon Naika Gakkai Zasshi, 2011
Yoshikazu Tamori, Tetsuya Takahashi, Shinsuke Nakajima, Yuki Nishimoto, K. Ohno, Minoru Takemoto, Koutaro Yokote, Tetsuya Kita, Masaharu Tsutsumi   +8 more
openalex   +3 more sources

Single Nucleotide Polymorphism WRN Leu1074Phe Is Associated with Prostate Cancer Susceptibility in Chinese Subjects [PDF]

, 2011
Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer.
Huang, Peng, Kaku, Haruki, Kumon, Hiromi, Li, Ming, Na, Yanqun, Nasu, Yasutomo, Sakai, Akiko, Shimizu, Kenji, Wang, Lei, Wang, Xiaofeng, Watanabe, Masami, Xie, Liping, Xu, Kexin, Yang, Kai, Zhang, Jiheng   +14 more
core   +1 more source

Epigenetic Regulation of Werner Syndrome Gene in Age-Related Cataract

Journal of Ophthalmology, 2015
Purpose. To examine the promoter methylation and histone modification of WRN (Werner syndrome gene), a DNA repair gene, and their relationship with the gene expression in age-related cataract (ARC) lens. Methods.
Xi Zhu, Guowei Zhang, Lihua Kang, Huaijin Guan   +3 more
doaj   +1 more source

Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells

eLife, 2019
Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent functional screening data of cancer cell lines we identify Werner syndrome helicase (WRN) as a novel specific vulnerability of microsatellite ...
Simone Lieb, Silvia Blaha-Ostermann, Elisabeth Kamper, Janine Rippka, Cornelia Schwarz, Katharina Ehrenhöfer-Wölfer, Andreas Schlattl, Andreas Wernitznig, Jesse J Lipp, Kota Nagasaka, Petra van der Lelij, Gerd Bader, Minoru Koi, Ajay Goel, Ralph A Neumüller, Jan-Michael Peters, Norbert Kraut, Mark A Pearson, Mark Petronczki, Simon Wöhrle   +19 more
doaj   +1 more source