A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin α-dependent nuclear localization signals. [PDF]
Protein SciAbstract Nucleocytoplasmic transport regulates the passage of proteins between the nucleus and cytoplasm. In the best characterized pathway, importin (IMP) α bridges cargoes bearing basic, classical nuclear localization signals (cNLSs) to IMPβ1, which mediates transport through the nuclear pore complex.
Cross EM +10 more
europepmc +2 more sources
DNA Virus Detection in Olfactory Neuroblastomas Using Targeted Enrichment NGS. [PDF]
NeuropathologyABSTRACT A variety of malignancies can be found in the sinonasal tract including the nasal cavity, paranasal sinuses, and skull base. Many of these are attributed to viruses, for example, carcinomas with the presence of transcriptionally active high‐risk human papillomavirus, as well as Epstein–Barr virus associated malignant lymphoepithelial carcinoma
Jauhiainen MK +7 more
europepmc +2 more sources
Prevalence of DNA of fourteen human polyomaviruses determined in blood donors. [PDF]
Transfusion, 2019 Abstract BACKGROUND Human polyomaviruses (HPyVs), like herpesviruses, cause persistent infection in a large part of the population. In immunocompromised and elderly patients, PyVs cause severe diseases such as nephropathy (BK polyomavirus [BKPyV]), progressive multifocal leukoencephalopathy (JC polyomavirus [JCPyV]), and skin cancer (Merkel cell ...
Kamminga S +4 more
europepmc +2 more sources
Activation of Macrophages by Oligomeric Proteins of Different Size and Origin. [PDF]
Mediators Inflamm, 2018 Activation of macrophages is one of the key processes in generating the immune response against pathogens or misfolded/aggregated otherwise unharmful host’s proteins. Antigens and their immune complexes (IC) may shape macrophage phenotype in various directions.
Dalgėdienė I +2 more
europepmc +2 more sources
Production of recombinant VP1-derived virus-like particles from novel human polyomaviruses in yeast [PDF]
, 2015 Background: Eleven new human polyomaviruses (HPyVs) have been identified in the last decade. Serological studies show that these novel HPyVs sub-clinically infect humans at an early age.
Alma Gedvilaite +5 more
core +1 more source
Infrequent detection of KI, WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy. [PDF]
PLoS ONE, 2011 Conflicting prevalence of newly identified KI (KIPyV), WU (WUPyV) and Merkel Cell Carcinoma (MCPyV) polyomaviruses have been reported in progressive multifocal leukoencephalopathy (PML) patient samples, ranging from 0 to 14.3%. We analyzed the prevalence
Xin Dang +5 more
doaj +1 more source
Survey of KI, WU, MW and STL polyomavirus in cancerous and non-cancerous lung tissues [PDF]
, 2018 K
Bidiga, László +4 more
core +1 more source
Evaluation of yield of currently available diagnostics by sample type to optimize detection of respiratory pathogens in patients with a community-acquired pneumonia [PDF]
, 2013 Background: For the detection of respiratory pathogens, the sampling strategy may influence the diagnostic yield. Ideally, samples from the lower respiratory tract are collected, but they are difficult to obtain.
Huijskens, E. (Elisabeth) +4 more
core +11 more sources
No Evidence of Human Polyomavirus 9, WU and KI DNA in Kidney and Urinary Bladder Tumour Tissue Samples [PDF]
, 2016 KAL
Bidiga, László +3 more
core +1 more source
WU Polyomavirus in Respiratory Epithelial Cells from Lung Transplant Patient with Job Syndrome
Emerging Infectious Diseases, 2015 We detected WU polyomavirus (WUPyV) in a bronchoalveolar lavage sample from lungs transplanted into a recipient with Job syndrome by using immunoassays specific for the WUPyV viral protein 1.
Erica A. Siebrasse +9 more
doaj +1 more source