Results 101 to 110 of about 169,270 (280)

Ground states of critical and supercritical problems of Brezis-Nirenberg type

, 2015
We study the existence of symmetric ground states to the supercritical problem \[ -\Delta v=\lambda v+\left\vert v\right\vert ^{p-2}v\text{ \ in }\Omega,\qquad v=0\text{ on }\partial\Omega, \] in a domain of the form \[ \Omega=\{(y,z)\in\mathbb{R}^{k+1 ...
Clapp, Mónica, Pistoia, Angela, Szulkin, Andrzej   +2 more
core   +1 more source

Overcoming the Trade‐Off Between Magnetic Coupling and Electrical Insulation in Soft Magnetic Materials via Nanochain Engineering

Advanced Science, EarlyView.
This study employs a nanochain engineering approach combined with an in situ oxidation strategy to fabricate self‐insulating iron‐based magnetic nanochains, addressing the challenge of balancing magnetic coupling and electrical insulation in soft magnetic materials.
Dingrong Zuo, Lichen Liu, Haibo Ke, Rongsheng Bai, Huaping Ding, Jing Zhou, Zhenxiang Cheng, Peng Yu, Weihua Wang   +8 more
wiley   +1 more source

Expression of WW Domain-Containing Oxidoreductase WOX1 in Human Nervous System Tumors

Analytical Cellular Pathology, 2013
Background and ObjectiveS: We aimed to evaluate the expression levels of the tumor suppressor WOX1 in nervous system tumors and its co-expression with p53 and neurofibromatosis type 2/merlin (NF2) tumor suppressor gene products.
Ming-Fu Chiang, Shur-Tzu Chen, Chen-Peng Lo, Chun-I Sze, Nan-Shan Chang, Yu-Jen Chen   +5 more
doaj   +1 more source

On Exact Multi-fractal Spectrum of the Whole-Plane SLE

, 2012
We consider the whole-plane Shramm-Loewner evolution. Using exact solutions of fundamental equations for moments of derivative of conformal mappings we determine its average integral means beta-spectrum.Comment: Significantly updated version. arXiv admin
Loutsenko, Igor, Yermolayeva, Oksana
core   +1 more source

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Beyond growth signaling: apoptotic sensor MERTK activates AKT by a novel mechanism

Molecular & Cellular Oncology, 2019
Canonically the oncogenic kinase AKT is activated by growth signals. Our work suggests apoptotic materials, abundant in tumors, also contribute to AKT activation by stimulating MERTK that in turn phosphorylates Y26 in the AKT PH domain.
Yanqiong Zhang, H. Shelton Earp, Pengda Liu   +2 more
doaj   +1 more source

The rise and fall of the fourth quark-lepton generation

, 2013
The existence of the fourth quark-lepton generation is not excluded by the electroweak precision data. However, the recent results on the 126 GeV higgs boson production and decay do not allow an extra generation at least as far as the perturbation theory
Vysotsky, M. I.
core   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

Nature Communications, 2018
In breast cancer, the loss of expression of WW domain-containing oxireductase (Wwox) has been observed. Here, the authors illustrate that in triple negative breast cancer models Wwox suppresses metastasis and proliferation via the JAK2/STAT3 pathway.
Renxu Chang, Lele Song, Yi Xu, Yanjun Wu, Cheng Dai, Xinyu Wang, Xia Sun, Yingyong Hou, Wei Li, Xianbao Zhan, Lixing Zhan   +10 more
doaj   +1 more source

3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species

Advanced Science, EarlyView.
ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu, Chenhui Han, Cheng Xue, Manyi Sun, Bobo Song, Yongsong Xue, Guangyan Yang, Shaozhuo Xu, Wei Wei, Jiaming Li, Runze Wang, Jun Wu   +11 more
wiley   +1 more source