WWOX and Its Binding Proteins in Neurodegeneration [PDF]
Cells, 2021 WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for Alzheimer’s disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal SDR domain and interacts with Tau phosphorylating enzymes ERK, JNK, and GSK-3β ...
Che-Yu Hsu +6 more
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Normal cells repel WWOX-negative or -dysfunctional cancer cells via WWOX cell surface epitope 286-299 [PDF]
Communications Biology, 2021 Yu-An Chen et al characterize the role of cell surface epitopes of the tumor suppressor protein WWOX in cell–cell recognition. The find that cells expressing functional WWOX, repel cancer cells which express dysfunctional WWOX or lack this protein, in a ...
Yu-An Chen +9 more
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Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer [PDF]
Advanced ScienceDespite WWOX's established role as a tumor suppressor, conclusive evidence linking germline WWOX loss‐of‐function variants to oncogenesis remains scarce.
Xiaopeng Zhang +8 more
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A multi-exon deletion within WWOX is associated with a 46,XY disorder of sex development [PDF]
, 2011 Disorders of sex development (DSD) are congenital conditions where chromosomal, gonad or genital development is atypical. In a significant proportion of 46,XY DSD cases it is not possible to identify a causative mutation, making genetic counseling ...
AJ Notini +32 more
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Functional genetic variant of WW domain-containing oxidoreductase (WWOX) gene is associated with hepatocellular carcinoma risk. [PDF]
PLoS ONE, 2017 BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Human WW domain-containing oxidoreductase (WWOX) gene has been identified as a tumor suppressor gene in multiple cancers.
Hsiang-Lin Lee +5 more
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Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus [PDF]
Neurobiology of Disease, 2019 The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented.
Tabish Hussain +11 more
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Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFβ/BMP2 signaling [PDF]
Cell Death and Disease, 2022 Pancreatic cancer is one of the most lethal cancers, owing to its late diagnosis and resistance to chemotherapy. The tumor suppressor WW domain-containing oxidoreductase (WWOX), one of the most active fragile sites in the human genome (FRA16D), is ...
Hussam Husanie +7 more
doaj +2 more sources
B-cell–specific Wwox deletion promotes plasmablastic tumor development and proinflammatory signatures in myeloma model [PDF]
Blood Neoplasia: Deletions and translocations affecting WWOX accompanied by loss of expression are frequently observed in B-cell neoplasms and are linked to poor prognosis.
Tabish Hussain +5 more
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Novel Hydrogel-Mediated Lentiviral Gene Delivery via Intravesical Administration for Bladder Cancer Treatment [PDF]
PharmaceuticsBackground/Objectives: Bladder urothelial carcinoma is a frequent malignant tumor of the urinary system, characterized by its high rates of recurrence and resistance to chemotherapy.
Ching-Wen Liu +4 more
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Frontiers in Cellular Neuroscience, 2019 The brain is the most functionally organized structure of all organs. It manages behavior, perception and higher cognitive functions. The WWOX gene is non-classical tumor suppressor gene, which has been shown to have an impact on proliferation, apoptosis
Katarzyna Kośla +5 more
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