Results 31 to 40 of about 6,450 (234)

WWOX in biological control and tumorigenesis [PDF]

Journal of Cellular Physiology, 2007
AbstractThe WW domain‐containing oxidoreductase (WWOX) gene is located at 16q23.1–16q23.2, a region that spans the second most common human fragile site, FRA16D. The WWOX protein contains two N‐terminal WW domains and a central short chain oxidoreductase‐like domain.
Rami I, Aqeilan, Carlo M, Croce
openaire   +2 more sources

Pleiotropic tumor suppressor functions of WWOX antagonize metastasis [PDF]

Signal Transduction and Targeted Therapy, 2020
AbstractTumor progression and metastasis are the major causes of death among cancer associated mortality. Metastatic cells acquire features of migration and invasion and usually undergo epithelia-mesenchymal transition (EMT). Acquirement of these various hallmarks rely on different cellular pathways, including TGF-β and Wnt signaling.
Saleh Khawaled, Giovanni Nigita, Rosario Distefano, Sara Oster, Sung‐Suk Suh, Yoav Smith, Abed Khalaileh, Yong Peng, Carlo M. Croce, Tamar Geiger, Victoria L. Seewaldt, Rami I. Aqeilan   +11 more
openalex   +3 more sources

WWOX-related epileptic encephalopathy caused by a novel mutation in the WWOX gene: a case report. [PDF]

Front Pediatr
BackgroundWWOX-related epileptic encephalopathy is an autosomal recessive disorder caused by mutations in the WW-containing oxidoreductase gene, characterized by the onset of refractory seizures in infants. Early-onset epilepsy, electroencephalography abnormalities, and developmental delay or degeneration are the main clinical manifestations.
Feng D, Li Y, Zhang YT, Song YJ, Qin DY, Wang F.   +5 more
europepmc   +4 more sources

Loss of WWOX expression in human extrahepatic cholangiocarcinoma

Journal of Cancer Research and Clinical Oncology, 2008
WW domain-containing oxidoreductase (WWOX) is a tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1. To investigate the role of the WWOX gene in the development of extrahepatic cholangiocarcinoma (ECC), 30 tissue samples of ECC were examined.Loss of heterozygosity (LOH), real time reverse transcription PCR (RT ...
Mei Wang, Jun Gu, Yajie Wang, Biao Gong
openalex   +4 more sources

Wwox Deficiency Causes Downregulation of Prosurvival ERK Signaling and Abnormal Homeostatic Responses in Mouse Skin

Frontiers in Cell and Developmental Biology, 2020
Deficiency of tumor suppressor WW domain-containing oxidoreductase (WWOX) in humans and animals leads to growth retardation and premature death during postnatal developmental stages. Skin integrity is essential for organism survival due to its protection
Ying-Tsen Chou, Feng-Jie Lai, Feng-Jie Lai, Nan-Shan Chang, Nan-Shan Chang, Li-Jin Hsu, Li-Jin Hsu   +6 more
doaj   +1 more source

The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding [PDF]

, 2013
Background: The WW domain containing protein WWOX has been postulated to behave as a tumor suppressor in breast and other cancers. Expression of this protein is lost in over 70% of ER negative tumors.
Abba, Martín Carlos, Aldaz, Claudio Marcelo, Ferguson, Brent W., Gao, Xinsheng, Jeter, Collene R., Lee, Jaeho, Zelazowski, Maciej J.   +6 more
core   +3 more sources

Epigenetic and genetic alterations affect the WWOX gene in head and neck squamous cell carcinoma. [PDF]

PLoS ONE, 2015
Different types of genetic and epigenetic changes are associated with HNSCC. The molecular mechanisms of HNSCC carcinogenesis are still undergoing intensive investigation.
Seda Ekizoglu, Pelin Bulut, Emin Karaman, Erkan Kilic, Nur Buyru   +4 more
doaj   +1 more source

Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples. [PDF]

, 2014
BackgroundSince tumor suppressor gene function may be lost through hypermethylation, we assessed whether the demethylating agent decitabine could increase tumor suppressor gene expression clinically.
Aldaz, Marcelo, Gupta, Sanjay, Hong, David, Issa, Jean-Pierre, Jelinek, Jaroslav, Kurzrock, Razelle, Nunez, Maria I, Stewart, David J, Wistuba, Ignacio I   +8 more
core   +3 more sources

Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with carcinogenesis [PDF]

, 2006
Common fragile sites (cfs) are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Several investigations support the view that common fragile sites play a role in carcinogenesis.
A Caputo, A Matsuyama, A Musio, Alda Maria Puliti, AM Casper, Angela Re, CD Hou, CT Miller, D Corà, D Corà, D Iliopoulos, Davide Cora, E Birney, H Ishii, I Sbrana, I Sbrana, Isabella Sbrana, ISCN, J Bartkova, J Hoshen, K Mimori, KA Cimprich, KA Nyberg, LV O'Keefe, M Ashburner, M Fabbri, M Schwartz, Michele Caselle, Newman MEJ, NS Chang, P Hoglund, RS Cha, S Corbin, S Gasser, SL Reiner, T Oyama, TW Glover, U Krummrei, VG Gorgoulis, Y Zhu   +39 more
core   +5 more sources

WWOX protein expression in normal human tissues [PDF]

Journal of Molecular Histology, 2006
WWOX is a putative tumor suppressor gene that spans approximately a 1 Mb genomic region and is the site for the second most common chromosomal fragile site, FRA16D at 16q23. Various studies have focused on the expression of WWOX in human cancer mostly at the RNA level, but little is known about the normal pattern of WWOX protein expression in non ...
Maria I, Nunez, John, Ludes-Meyers, C Marcelo, Aldaz   +2 more
openaire   +2 more sources