Results 31 to 40 of about 6,282 (233)

Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION This study investigates ancestry‐specific changes in induced pluripotent stem cell (iPSC)‐derived oligodendroglia genomic regulation in Alzheimer's disease (AD), addressing diversity gaps by including African, Amerindian, and European ancestries in the analysis. METHODS We generated 12 iPSC lines from AD patients and controls with
Ramirez AM, Nasciben LB, Moura S, Coombs L, Rajabli F, DeRosa BA, Whitehead PL, Adams LD, Starks TD, Mena PR, Illanes-Manrique M, Tejada S, Byrd GS, Caban-Holt A, Cuccaro ML, McInerney K, Cornejo-Olivas MR, Feliciano-Astacio BE, Wang L, Robayo MC, Xu W, Jin F, Pericak-Vance MA, Griswold AJ, Young JI, Dykxhoorn DM, Vance JM.   +26 more
europepmc   +2 more sources

Wwox inactivation enhances mammary tumorigenesis [PDF]

Oncogene, 2011
Breast cancer is the leading cause of cancer-related death in women worldwide. Expression of the WWOX tumor suppressor is absent or reduced in a large proportion of breast tumors suggesting that loss of WWOX may contribute to breast tumorigenesis. Wwox-deficient mice die by 3-4 weeks of age precluding adult tumor analysis.
Rami I. Aqeilan, B Maly, Zaidoun Salah, Nicola Zanesi, Zafar Nawaz, Mohammad Abu-Odeh, Suhaib K Abdeen, Carlo Croce, Yoav Smith, Rozina Tufail   +9 more
openaire   +3 more sources

Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches. [PDF]

PLoS ONE, 2012
Loss of WWOX expression has been reported in many different cancers including breast cancer. Elucidating the function of this gene in adult tissues has not been possible with full Wwox knockout models. Here we characterize the first conditional models of
Brent W Ferguson, Xinsheng Gao, Hyunsuk Kil, Jaeho Lee, Fernando Benavides, Martin C Abba, C Marcelo Aldaz   +6 more
doaj   +1 more source

The degree of segmental aneuploidy measured by total copy number abnormalities predicts survival and recurrence in superficial gastroesophageal adenocarcinoma [PDF]

, 2014
Background: Prognostic biomarkers are needed for superficial gastroesophageal adenocarcinoma (EAC) to predict clinical outcomes and select therapy. Although recurrent mutations have been characterized in EAC, little is known about their clinical and ...
A Janssen, AH Marx, AJ Lee, AM Dulak, AM Dulak, B Fu, BJ Reid, CA Ong, CD Schweighofer, Christin M. Sciulli, CM Jacobsen, D Choma, D Hanahan, D Hirsch, DJ Nancarrow, DP Cahill, ER Thompson, F Boudreau, G Ng, GA Prasad, George K. Michalopoulos, GJ Kops, H Lango Allen, H Pohl, HJ Stein, J Gu, J Theisen, J. Michael Krill-Burger, James D. Luketich, JC Saldivar, JO Korbel, Jon M. Davison, Katie S. Nason, L Lin, LA Lai, LO Baumbusch, Lori A. Kelly, M Greaves, M Sarbia, M Schweigert, M Tuefferd, Maureen A. Lyons-Weiler, MB Menke-Pluymers, Melissa Yee, N Deng, N McGranahan, NJ Birkbak, NS Chang, O Pech, OM Radu, PJ Stephens, R Beroukhim, R Roylance, S Bayraktar, S Li, SE Araujo, SL Carter, Svetlana Pack, T Nakamura, TM Kim, TW Rice, TW Rice, VI Gaidzik, William A. LaFramboise, WJ Blot, WJ Kent, XY Goh, YJ Bang   +67 more
core   +6 more sources

Association of Wwox with ErbB4 in Breast Cancer [PDF]

Cancer Research, 2007
Abstract WWOX, WW domain-containing oxidoreductase, is a tumor suppressor that is altered in many human cancers, including breast cancer. Wwox interacts with the ErbB4 receptor, reduces nuclear translocation of the cleaved intracellular domain of ErbB4, and inhibits its transactivation function mediated through Yes-associated protein ...
Jorma Isola, Carlo M. Croce, Rami I. Aqeilan, Johan Lundin, Marius Sudol, Heikki Joensuu, Milena S. Nicoloso, Valentina Donati, Klaus Elenius, Anna Korhonen, Eugenio Gaudio, Maria Sundvall   +11 more
openaire   +3 more sources

Wwox Deficiency Causes Downregulation of Prosurvival ERK Signaling and Abnormal Homeostatic Responses in Mouse Skin

Frontiers in Cell and Developmental Biology, 2020
Deficiency of tumor suppressor WW domain-containing oxidoreductase (WWOX) in humans and animals leads to growth retardation and premature death during postnatal developmental stages. Skin integrity is essential for organism survival due to its protection
Ying-Tsen Chou, Feng-Jie Lai, Feng-Jie Lai, Nan-Shan Chang, Nan-Shan Chang, Li-Jin Hsu, Li-Jin Hsu   +6 more
doaj   +1 more source

A multi-exon deletion within WWOX is associated with a 46,XY disorder of sex development [PDF]

, 2011
Disorders of sex development (DSD) are congenital conditions where chromosomal, gonad or genital development is atypical. In a significant proportion of 46,XY DSD cases it is not possible to identify a causative mutation, making genetic counseling ...
AJ Notini, AJ Paige, AK Bednarek, Andrew Sinclair, D Wilhelm, DM Maatouk, E Sutton, Erin Turbitt, H Stoop, Jacqueline Hewitt, JH Ludes-Meyers, Leendert Looijenga, LH Looijenga, M Cools, M Cools, Martine Cools, MI Nunez, N Bouteille, PA Lee, Peter Koopman, R Hersmus, Remko Hersmus, RI Aqeilan, RI Aqeilan, RI Aqeilan, RI Aqeilan, S Del Mare, SJ White, SJ White, Stefan White, Stenvert Drop, Vincent Harley, Yvonne van der Zwan   +32 more
core   +1 more source

A Role for the WWOX Gene in Prostate Cancer [PDF]

Cancer Research, 2006
Abstract Expression of the WWOX gene, encompassing the common chromosome fragile site FRA16D, is altered in a large fraction of cancers of various types, including prostate cancer. We have examined expression and biological functions of WWOX in prostate cancer.
QIN HR, ILIOPOULOS D, SEMBA S, FABBRI M, DRUCK T, VOLINIA, Stefano, CROCE CM, MORRISON CD, KLEIN RD, HUEBNER K.   +9 more
openaire   +4 more sources

Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with carcinogenesis [PDF]

, 2006
Common fragile sites (cfs) are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Several investigations support the view that common fragile sites play a role in carcinogenesis.
A Caputo, A Matsuyama, A Musio, Alda Maria Puliti, AM Casper, Angela Re, CD Hou, CT Miller, D Corà, D Corà, D Iliopoulos, Davide Cora, E Birney, H Ishii, I Sbrana, I Sbrana, Isabella Sbrana, ISCN, J Bartkova, J Hoshen, K Mimori, KA Cimprich, KA Nyberg, LV O'Keefe, M Ashburner, M Fabbri, M Schwartz, Michele Caselle, Newman MEJ, NS Chang, P Hoglund, RS Cha, S Corbin, S Gasser, SL Reiner, T Oyama, TW Glover, U Krummrei, VG Gorgoulis, Y Zhu   +39 more
core   +5 more sources

Alteration of WWOX in human cancer, a clinical view [PDF]

Experimental Biology and Medicine, 2015
WWOX gene is located in FRA16D, the highly affected chromosomal fragile site. Its tumor suppressor activity has been proposed on a basis of numerous genomic alterations reported in chromosome 16q23.3–24.1 locus. WWOX is affected in many cancers, showing as high as 80% loss of heterozygosity in breast tumors.
Izabela Baryła, Andrzej K. Bednarek, Ewa Styczeń-Binkowska   +2 more
openaire   +3 more sources