Results 41 to 50 of about 6,450 (234)
WWOX Tumor Suppressor Gene in Breast Cancer, a Historical Perspective and Future Directions
Frontiers in Oncology, 2018 The WWOX tumor suppressor gene is located at 16q23. 1–23.2, which covers the region of FRA16D—a common fragile sites. Deletions within the WWOX coding sequence are observed in up to 80% of breast cancer cases, which makes it one of the most common ...
Karolina Pospiech +2 more
doaj +1 more source
C6orf10 low-frequency and rare variants in italian multiple sclerosis patients [PDF]
, 2019 In light of the complex nature of multiple sclerosis (MS) and the recently estimated contribution of low-frequency variants into disease, decoding its genetic risk components requires novel variant prioritization strategies.
Balestra, Dario +16 more
core +2 more sources
Histology and histopathology, 2008 Loss of heterozygosity and chromosomal rearrangement of the WWOX gene, which is located at 16q23.3-24.1, have been detected in ovarian, breast, hepatocellular, and prostate carcinomas and in other neoplasias. This gene, which spans the common chromosomal fragile site 16D, contains 9 exons and encodes a 46 kDa WWOX protein that contains 414 amino acids.
Yang, Jilong, Zhang, Wei
openaire +3 more sources
VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
BMC Biology, 2018 Background The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the pro-apoptotic protein p73α ...
Florian Bonin +18 more
doaj +1 more source
A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity [PDF]
, 2015 The coordinated regulation of mitochondrial and nuclear activities is essential for cellular respiration and its disruption leads to mitochondrial dysfunction, a hallmark of ageing.
A Dillin +58 more
core +2 more sources
LncRNA WWOX-AS1 sponges miR-20b-5p in hepatocellular carcinoma and represses its progression by upregulating WWOX [PDF]
Cancer Biology & Therapy, 2020 Increasing evidence has revealed that long noncoding RNAs (lncRNAs) emerge as pivotal regulators in diverse cancers, including hepatocellular carcinoma (HCC). This study was conducted to investigate the role of lncRNA WWOX antisense RNA 1 (WWOX-AS1) in HCC progression.
Dafeng Xu +8 more
openaire +2 more sources
Frontiers in Oncology, 2021 IntroductionThe presence of common fragile sites is associated with no-accidental chromosomal instability which occurs prior to carcinogenesis. The WWOX gene spans the second most active fragile site: FRA16D.
Damian Kołat +3 more
doaj +1 more source
WWOX, A NEW POTENTIAL TUMOR SUPPRESSOR GENE [PDF]
Biomedical Papers, 2007 WWOX (WW domain-containing oxidoreductase) gene, located on chromosome 16q 23.3-24.1 in the region recognized as the common fragile site FRA16D is considered to be a tumor suppressor gene involved in various cancers: breast, ovarian, prostate, esophageal, lung, pancreatic, gastric and hepatic.
Renata, Hezova +2 more
openaire +2 more sources
WWOX (WW domain containing oxidoreductase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2008 Review on WWOX (WW domain containing oxidoreductase), with data on DNA, on the protein encoded, and where the gene is implicated.
Druck, Teresa +2 more
openaire +1 more source
Genome-wide association analysis identifies six new loci associated with forced vital capacity [PDF]
, 2014 Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and ...
A Bill Musk +216 more
core +4 more sources