Results 41 to 50 of about 6,282 (233)

Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFβ/BMP2 signaling

Cell Death and Disease, 2022
Pancreatic cancer is one of the most lethal cancers, owing to its late diagnosis and resistance to chemotherapy. The tumor suppressor WW domain-containing oxidoreductase (WWOX), one of the most active fragile sites in the human genome (FRA16D), is ...
Hussam Husanie, Muhannad Abu-Remaileh, Kian Maroun, Lina Abu-Tair, Hazem Safadi, Karine Atlan, Talia Golan, Rami I. Aqeilan   +7 more
doaj   +1 more source

Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples. [PDF]

, 2014
BackgroundSince tumor suppressor gene function may be lost through hypermethylation, we assessed whether the demethylating agent decitabine could increase tumor suppressor gene expression clinically.
Aldaz, Marcelo, Gupta, Sanjay, Hong, David, Issa, Jean-Pierre, Jelinek, Jaroslav, Kurzrock, Razelle, Nunez, Maria I, Stewart, David J, Wistuba, Ignacio I   +8 more
core   +3 more sources

WWOX expression in giant cell lesions of the jaws [PDF]

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2013
To investigate WWOX messenger RNA (mRNA) transcriptional levels in giant cell lesions (GCLs) of the jaws and associate its expression with clinical parameters.In this pilot study, quantitative reverse-transcription polymerase chain reaction was performed to analyze WWOX expression in 6 central giant cell lesions (CGCLs) (including 2 aggressive), 5 ...
Carolina Cavaliéri Gomes, Paulo Eduardo Alencar Souza, Marina Gonçalves Diniz, Fabrício Rezende Amaral, Ricardo Santiago Gomez, Vanessa Fátima Bernardes   +5 more
openaire   +3 more sources

WWOX Loss of Function in Neurodevelopmental and Neurodegenerative Disorders [PDF]

International Journal of Molecular Sciences, 2020
The WWOX gene was initially discovered as a putative tumor suppressor. More recently, its association with multiple central nervous system (CNS) pathologies has been recognized. WWOX biallelic germline pathogenic variants have been implicated in spinocerebellar ataxia type 12 (SCAR12; MIM:614322) and in early infantile epileptic encephalopathy (EIEE28;
C. Marcelo Aldaz, Tabish Hussain
openaire   +3 more sources

WWOX Tumor Suppressor Gene in Breast Cancer, a Historical Perspective and Future Directions

Frontiers in Oncology, 2018
The WWOX tumor suppressor gene is located at 16q23. 1–23.2, which covers the region of FRA16D—a common fragile sites. Deletions within the WWOX coding sequence are observed in up to 80% of breast cancer cases, which makes it one of the most common ...
Karolina Pospiech, Elzbieta Płuciennik, Andrzej K. Bednarek   +2 more
doaj   +1 more source

Epigenetic and genetic alterations affect the WWOX gene in head and neck squamous cell carcinoma. [PDF]

PLoS ONE, 2015
Different types of genetic and epigenetic changes are associated with HNSCC. The molecular mechanisms of HNSCC carcinogenesis are still undergoing intensive investigation.
Seda Ekizoglu, Pelin Bulut, Emin Karaman, Erkan Kilic, Nur Buyru   +4 more
doaj   +1 more source

Genetic etiologies with a large NGS panel in a monocentric cohort of 1000 patients with pediatric onset epilepsies. [PDF]

Epilepsia Open
Abstract Objective Genetic testing is now included in the diagnostic assessment of childhood onset epilepsies. We evaluated the yield of a targeted next generation sequencing (TNGS) panel dedicated to pediatric epilepsies. Methods We tested by TNGS panel 1000 consecutive patients presenting with childhood onset epilepsies and including mainly patients ...
Barcia G, Chemaly N, Gobin-Limballe S, Losito E, Aubart M, Sarda E, Assouline Z, Plante-Bordeneuve P, Hully M, Barrois R, Barnerias C, Sareidaki D, Zeitoun DC, Eisermann M, Fourrage C, Hanein S, Rio M, Boddaert N, Desguerre I, Kaminska A, Steffann J, Nabbout R.   +21 more
europepmc   +2 more sources

C6orf10 low-frequency and rare variants in italian multiple sclerosis patients [PDF]

, 2019
In light of the complex nature of multiple sclerosis (MS) and the recently estimated contribution of low-frequency variants into disease, decoding its genetic risk components requires novel variant prioritization strategies.
Balestra, Dario, Benazzo, Andrea, Bernardi, Francesco, Bovolenta, Matteo, Bozzini, Nicolò, Gemmati, Donato, Guidi, Irene, Laino, Lorenza Anna, Lunghi, Barbara, Marchetti, Giovanna, Menegatti, Erica, Meneghetti, Silvia, Salvi, Fabrizio, Scapoli, Chiara, Straudi, Sofia, Zamboni, Paolo, Ziliotto, Nicole   +16 more
core   +2 more sources

WWOX tumor suppressor gene.

Histology and histopathology, 2008
Loss of heterozygosity and chromosomal rearrangement of the WWOX gene, which is located at 16q23.3-24.1, have been detected in ovarian, breast, hepatocellular, and prostate carcinomas and in other neoplasias. This gene, which spans the common chromosomal fragile site 16D, contains 9 exons and encodes a 46 kDa WWOX protein that contains 414 amino acids.
Yang, Jilong, Zhang, Wei
openaire   +4 more sources

WWOX loss activates aerobic glycolysis [PDF]

Molecular & Cellular Oncology, 2014
Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis-a state known as "aerobic glycolysis." Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch.
Rami I. Aqeilan, Muhannad Abu-Remaileh, Victoria L. Seewaldt   +2 more
openaire   +3 more sources