Results 51 to 60 of about 6,282 (233)

VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX

BMC Biology, 2018
Background The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the pro-apoptotic protein p73α ...
Florian Bonin, Karim Taouis, Paula Azorin, Ambre Petitalot, Zakia Tariq, Sebastien Nola, Nadège Bouteille, Sandrine Tury, Sophie Vacher, Ivan Bièche, Khadija Ait Rais, Gaelle Pierron, Laetitia Fuhrmann, Anne Vincent-Salomon, Etienne Formstecher, Jacques Camonis, Rosette Lidereau, François Lallemand, Keltouma Driouch   +18 more
doaj   +1 more source

WWOX Modulates ROS-Dependent Senescence in Bladder Cancer

Molecules, 2022
The tumor-suppressor gene, WW domain-containing oxidoreductase (WWOX), has been found to be lost in various types of cancers. ROS result as a tightly regulated signaling process for the induction of cell senescence.
Ching-Wen Liu, Po-Hen Chen, Tsan-Jung Yu, Kai-Jen Lin, Li-Ching Chang   +4 more
doaj   +1 more source

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity [PDF]

, 2015
The coordinated regulation of mitochondrial and nuclear activities is essential for cellular respiration and its disruption leads to mitochondrial dysfunction, a hallmark of ageing.
A Dillin, A Wong, AJ Whitmarsh, Alan J. Whitmarsh, AM Nargund, B Lakowski, BN Marbois, C Frezza, C Frokjaer-Jensen, C Lopez-Otin, C Yee, CE Riera, D Cristina, DA Hall, E Owusu-Ansah, E Zeiser, EB Kayser, F Levavasseur, FY Chueh, G Sutendra, G Wright, Gino B. Poulin, H Miyadera, J Yun, JE Aldridge, JJ Ewbank, JM Matés, JM Van Raamsdonk, K Itoh, Kate Fisher, KJ Livak, L Papa, LA Sena, LV O’Keefe, M Bar-Peled, MB Jensen, N Jiang, Nicholas Rooney, NS Chandel, O Yogev, O Yogev, OK Mirzoeva, RH Houtkooper, Richard M. Monaghan, Robert G. Barnes, S Brenner, S Felkai, S Suzuki, SJ Lee, SP Whelan, SW Tait, T Jonassen, T Jonassen, Tereza Andreou, TJ Schulz, VN Kotiadis, W Yang, X Liu, Y Wang   +58 more
core   +1 more source

WWOX: A fragile tumor suppressor

Experimental Biology and Medicine, 2014
WWOX, the WW domain-containing oxidoreductase gene at chromosome region 16q23.3–q24.1, spanning chromosomal fragile site FRA16D, encodes the 46 kDa Wwox protein, a tumor suppressor that is lost or reduced in expression in a wide variety of cancers, including breast, prostate, ovarian, and lung.
Kay Huebner, Morgan S. Schrock
openaire   +3 more sources

Fragile Gene WWOX Guides TFAP2A/TFAP2C-Dependent Actions Against Tumor Progression in Grade II Bladder Cancer

Frontiers in Oncology, 2021
IntroductionThe presence of common fragile sites is associated with no-accidental chromosomal instability which occurs prior to carcinogenesis. The WWOX gene spans the second most active fragile site: FRA16D.
Damian Kołat, Żaneta Kałuzińska, Andrzej K. Bednarek, Elżbieta Płuciennik   +3 more
doaj   +1 more source

The effects of protocadherin 8 and WWOX in prostate adenocarcinoma

Journal of Men's Health, 2022
Objective: The protocadherin 8 (PCDH8) gene, located on chromosome 13q14.3 encodes an integral membrane protein. WWOX (fragile site FRA16D oxido-reductase) is a tumor suppressor gene located in region 16q23.324.1. The aim of this study was to investigate
Mürüvvet Akçay Çelik, Havva Erdem, Soner Çankaya, Yeliz Kaşko Arıcı   +3 more
doaj   +1 more source

Genome-wide association analysis identifies six new loci associated with forced vital capacity [PDF]

, 2014
Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and ...
A Bill Musk, A Hofman, A Rosendahl, A Sountoulidis, Adaikalavan Ramasamy, Akshay Sood, AL Dixon, Alan F Wright, Alan L James, Alanna C Morrison, Albert Hofman, Albert Vernon Smith, Alexander Teumer, Alexessander Couto Alves, Alicja R Rudnicka, Ana Viñuela, Andrew P Morris, André G Uitterlinden, Ani Manichaikul, Anne Newman, Anne Viljanen, Anneli Pouta, AP Boyle, AS Dimas, AT Kho, B Devlin, B Gombojav, B Servin, Beate Koch, Bharat Thyagarajan, BL Browning, Blair H Smith, Bonnie R Joubert, Bruce M Psaty, Bruno H Stricker, Caroline Hayward, CE Elks, Chris Oldmeadow, Christian Gieger, Christopher J Hammond, Cisca Wijmenga, CJ Willer, CJ Zappala, Claudia Flexeder, CM Lindgren, CS Carlson, Daan W Loth, Dana B Hancock, David Couper, David J Lederer, David J Porteous, David P Strachan, DB Hancock, DB Hancock, Deborah L Jarvis, Dirkje S Postma, DJ Gottlieb, DR Nyholt, E Hodge, E Melén, E Repapi, EE Eichler, Elizabeth G Holliday, Erik Ingelsson, Erik Melén, Ernst Omenaas, Esteban G Burchard, Eva Albrecht, F Ashley, Fernando Rivadeneira, Fien M Verhamme, G Lettre, G Raghu, Gail Davies, Generation Scotland, George T O'Connor, Gudny Eiriksdottir, Guo Li, Guy G Brusselle, H Lango Allen, H Marike Boezen, H Takizawa, Harald Grallert, Harry Campbell, Henry Völzke, HJ Westra, HM Lee, Holger Schulz, Holly Trochet, Ian J Deary, Ian P Hall, Ian Sayers, Ida Surakka, Igor Rudan, Isabelle Pin, Ivana Kolcic, J Li, J Marchini, J Sung, J Sung, J Yang, Jaakko Kaprio, James F Wilson, JB Wilk, JB Wilk, Jemma B Wilk, Jennie Hui, Jennifer E Huffman, Jerome I Rotter, JH Park, Jing Hua Zhao, JM Cheverud, Joachim Heinrich, John Beilby, John M Starr, John R Attia, Joohon Sung, Josée Dupuis, Joyce B J van Meurs, JR Gibbs, Judith M Vonk, Juha Pekkanen, K Musunuru, K Zhang, Kari E North, Ken R Bracke, Kim de Jong, Kirsi H Pietiläinen, Kristin M Burkart, Kurt Lohman, Lars Lind, Laura R Loehr, Lenore J Launer, Leslie A Lange, Lewis J Smith, Lies Lahousse, Lina Zgaga, LJ Palmer, Lorna M Lopez, Louise V Wain, M Kimura, M Soler Artigas, M Uhlen, Marcy F Petrini, Marjo-Riitta Jarvelin, Marjolein J Peters, Markku Heliövaara, Martin D Tobin, Mary Wojczynski, María Soler Artigas, Matthias Wjst, Melissa Garcia, Mi Kyeong Lee, Mika Kähönen, Myriam Fornage, N van Putte-Katier, Nadia Hansel, Nathan C Gaddis, Nicholas D Hastie, Nicholas J Wareham, Nora Franceschini, O Dale Williams, Ozren Polasek, P Lange, Patricia A Cassano, Pau Navarro, Peter K Joshi, PG Burney, Pieter S Hiemstra, Pirro G Hysi, PJ McLaughlin, Qing Duan, R Graham Barr, Rajesh Kumar, Regina Hampel, Robert A Scott, Rodney J Scott, Ryan L Minster, Samuli Ripatti, Sarah H Wild, Sina A Gharib, SR Browning, ST Weiss, Stefan Enroth, Stefan Karrasch, Stephanie J London, Stephen B Kritchevsky, Stephen S Rich, Susan Campbell, Susan R Heckbert, Susan Redline, Sven Gläser, Taina Rantanen, Tamara B Harris, Tatijana Zemunik, Tess D Pottinger, Thomas Lumley, Thor Aspelund, Timothy D Spector, Tove Fall, Ulf Gyllensten, Veronique Vitart, Vilmundur Gudnason, WB Kannel, Wei Gao, Wenbo Tang, Wendy B White, Wendy L McArdle, WI de Boer, Woo Jin Kim, Xiangjun Gu, Xin-Qun Wang, Y Li, Yeon-Mok Oh, Yongmei Liu, YS Cho, Åsa Johansson   +216 more
core   +4 more sources

LncRNA WWOX-AS1 sponges miR-20b-5p in hepatocellular carcinoma and represses its progression by upregulating WWOX [PDF]

Cancer Biology & Therapy, 2020
Increasing evidence has revealed that long noncoding RNAs (lncRNAs) emerge as pivotal regulators in diverse cancers, including hepatocellular carcinoma (HCC). This study was conducted to investigate the role of lncRNA WWOX antisense RNA 1 (WWOX-AS1) in HCC progression.
Dafeng Xu, Xiangmei Liu, Jincai Wu, Yu Wang, Kailun Zhou, Wenmei Chen, Jiacheng Chen, Cheng Chen, Liang Chen   +8 more
openaire   +2 more sources

Self-aggregating TIAF1 in lung cancer progression [PDF]

, 2013
Recent studies have demonstrated that transforming growth factor beta (TGF-β1)-induced antiapoptotic factor (TIAF1) is able to form aggregates in the hippocampi of middle-aged normal individuals.
Chen-Yu Lu, Li-Jin Hsu, Nan-Shan Chang, Pei-Yi Chou, Qunying Hong, Ying-Tsen Chou, Yu-An Chen   +6 more
core   +1 more source

A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism

Cell Communication and Signaling, 2019
Background Tumor suppressor WWOX physically binds p53 and TIAF1 and together induces apoptosis and tumor suppression. To understand the molecular action, here we investigated the formation of WWOX/TIAF1/p53 triad and its regulation of cancer cell ...
Pei-Yi Chou, Sing-Ru Lin, Ming-Hui Lee, Lori Schultz, Chun-I Sze, Nan-Shan Chang   +5 more
doaj   +1 more source