Results 51 to 60 of about 6,450 (234)
PLoS ONE, 2009 WWOX, the gene that spans the second most common human chromosomal fragile site, FRA16D, is inactivated in multiple human cancers and behaves as a suppressor of tumor growth.
John H Ludes-Meyers +5 more
doaj +1 more source
WWOX: A fragile tumor suppressor
Experimental Biology and Medicine, 2014 WWOX, the WW domain-containing oxidoreductase gene at chromosome region 16q23.3–q24.1, spanning chromosomal fragile site FRA16D, encodes the 46 kDa Wwox protein, a tumor suppressor that is lost or reduced in expression in a wide variety of cancers, including breast, prostate, ovarian, and lung.
Morgan S, Schrock, Kay, Huebner
openaire +3 more sources
Self-aggregating TIAF1 in lung cancer progression [PDF]
, 2013 Recent studies have demonstrated that transforming growth factor beta (TGF-β1)-induced antiapoptotic factor (TIAF1) is able to form aggregates in the hippocampi of middle-aged normal individuals.
Chen-Yu Lu +6 more
core +1 more source
WWOX Oxidoreductase - Substrate and Enzymatic Characterization
Zeitschrift für Naturforschung C, 2011 WWOX is a tumour suppressor gene that spans the common fragile site FRA16D. Analysis of the WWOX expression pattern in normal human tissues showed the highest expression in testis, prostate, and ovary. Its altered expression has been demonstrated in different tissues and tumour types.
Anna, Sałuda-Gorgul +3 more
openaire +2 more sources
The effects of protocadherin 8 and WWOX in prostate adenocarcinoma
Journal of Men's Health, 2022 Objective: The protocadherin 8 (PCDH8) gene, located on chromosome 13q14.3 encodes an integral membrane protein. WWOX (fragile site FRA16D oxido-reductase) is a tumor suppressor gene located in region 16q23.324.1. The aim of this study was to investigate
Mürüvvet Akçay Çelik +3 more
doaj +1 more source
Cell Communication and Signaling, 2019 Background Tumor suppressor WWOX physically binds p53 and TIAF1 and together induces apoptosis and tumor suppression. To understand the molecular action, here we investigated the formation of WWOX/TIAF1/p53 triad and its regulation of cancer cell ...
Pei-Yi Chou +5 more
doaj +1 more source
WWOX guards genome stability by activating ATM [PDF]
Molecular & Cellular Oncology, 2015 Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be "hot spots" for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates ...
Hazan, Idit +3 more
openaire +2 more sources
Frontiers in Oncology, 2018 It has become clear from multiple studies that WWOX (WW domain-containing oxidoreductase) operates as a “non-classical” tumor suppressor of significant relevance in cancer progression.
Tabish Hussain +4 more
doaj +1 more source
Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas
Frontiers in Oncology, 2013 Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide and therapeutic drugs.
Ming-Fu eChiang +7 more
doaj +1 more source
HACE1 deficiency causes an autosomal recessive neurodevelopmental syndrome [PDF]
, 2015 Background: The genetic etiology of neurodevelopmental defects is extremely diverse, and the lack of distinctive phenotypic features means that genetic criteria are often required for accurate diagnostic classification. We aimed to identify the causative
Abdel-Salam +45 more
core +3 more sources