WWOX promotes osteosarcoma development via upregulation of Myc
Cell Death & Disease, 2023 Abstract Osteosarcoma is an aggressive bone tumor that primarily affects children and adolescents. This malignancy is highly aggressive, associated with poor clinical outcomes, and primarily metastasizes to the lungs.
Rania Akkawi +7 more
openaire +3 more sources
The RAG Model: a new paradigm for genetic risk stratification in multiple myeloma [PDF]
, 2014 Molecular studies have shown that multiple myeloma is a highly genetically heterogonous disease which may manifest itself as any number of diverse subtypes each with variable clinicopathological features and outcomes.
Chevassut, Timothy J +2 more
core +3 more sources
The WWOX gene in brain development and pathology [PDF]
Experimental Biology and Medicine, 2020 Shortly after its discovery in 2000, WWOX was hailed as a tumor suppressor gene. In subsequent years of research, this function was confirmed indisputably. Majority of tumors show high rate of loss of heterozygosity and decreased expression of WWOX.
K Kośla, Ż Kałuzińska, AK Bednarek
openaire +2 more sources
Expression profile of CREB knockdown in myeloid leukemia cells. [PDF]
, 2008 BackgroundThe cAMP Response Element Binding Protein, CREB, is a transcription factor that regulates cell proliferation, differentiation, and survival in several model systems, including neuronal and hematopoietic cells.
Cheng, Jerry C +6 more
core +2 more sources
Molecular Biology of the WWOX Gene That Spans Chromosomal Fragile Site FRA16D
Cells, 2021 It is now more than 20 years since the FRA16D common chromosomal fragile site was characterised and the WWOX gene spanning this site was identified. In this time, much information has been discovered about its contribution to disease; however, the normal
Cheng Shoou Lee +4 more
doaj +1 more source
Genome-Wide Copy Number Analysis in Esophageal Adenocarcinoma Using High-Density Single-Nucleotide Polymorphism Arrays [PDF]
, 2008 We applied whole-genome single-nucleotide polymorphism arrays to define a comprehensive genetic profile of 23 esophageal adenocarcinoma (EAC) primary tumor biopsies based on loss of heterozygosity (LOH) and DNA copy number changes.
Clouston, Andrew D +8 more
core +1 more source
BMC Cancer, 2005 Background The putative tumor suppressor WWOX gene spans the common chromosomal fragile site 16D (FRA16D) at chromosome area 16q23.3-24.1. This region is a frequent target for loss of heterozygosity and chromosomal rearrangement in ovarian, breast ...
Liu Jinsong +10 more
doaj +1 more source
Copy number variants are produced in response to low‐dose ionizing radiation in cultured cells [PDF]
, 2013 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106089/1/em21840 ...
Arlt, Martin F. +4 more
core +1 more source
Dynamic expression of genes associated with schizophrenia and bipolar disorder across development [PDF]
, 2019 Common genetic variation contributes a substantial proportion of risk for both schizophrenia and bipolar disorder. Furthermore, there is evidence of significant, but not complete, overlap in genetic risk between the two disorders.
Clifton, Nicholas E. +10 more
core +3 more sources
Molecular Alterations in Osteosarcomas of the Oral and Maxillofacial Region: A Scoping Review
Journal of Oral Pathology &Medicine, EarlyView.ABSTRACT Background Given the rarity and aggressive nature of osteosarcomas (OS) in the oral and maxillofacial region, understanding their molecular alterations is essential to improve diagnosis, prognosis, and guide targeted therapies. This study aimed to map molecular alterations associated with oral and maxillofacial OS, providing an overview of the
Iara Vieira Ferreira +6 more
wiley +1 more source