Results 61 to 70 of about 6,282 (233)

WWOX Oxidoreductase - Substrate and Enzymatic Characterization

Zeitschrift für Naturforschung C, 2011
WWOX is a tumour suppressor gene that spans the common fragile site FRA16D. Analysis of the WWOX expression pattern in normal human tissues showed the highest expression in testis, prostate, and ovary. Its altered expression has been demonstrated in different tissues and tumour types.
Andrzej K. Bednarek, Karolina Seta, Magdalena Nowakowska, Anna Sałuda-Gorgul   +3 more
openaire   +3 more sources

WWOX protein expression in normal human tissues [PDF]

Journal of Molecular Histology, 2006
WWOX is a putative tumor suppressor gene that spans approximately a 1 Mb genomic region and is the site for the second most common chromosomal fragile site, FRA16D at 16q23. Various studies have focused on the expression of WWOX in human cancer mostly at the RNA level, but little is known about the normal pattern of WWOX protein expression in non ...
John Ludes-Meyers, Maria I. Nunez, C. Marcelo Aldaz   +2 more
openaire   +3 more sources

Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas

Frontiers in Oncology, 2013
Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide and therapeutic drugs.
Ming-Fu eChiang, Pei-Yi eChou, Wan-Jen eWang, Chun-I eSze, Nan-Shan eChang, Nan-Shan eChang, Nan-Shan eChang, Nan-Shan eChang   +7 more
doaj   +1 more source

HACE1 deficiency causes an autosomal recessive neurodevelopmental syndrome [PDF]

, 2015
Background: The genetic etiology of neurodevelopmental defects is extremely diverse, and the lack of distinctive phenotypic features means that genetic criteria are often required for accurate diagnostic classification. We aimed to identify the causative
Abdel-Salam, Ahram, Alexander F Markham, Anglesio, Au, Carr, Chang, Christopher P Bennett, Clare V Logan, Corcoran, David A Parry, David T Bonthron, Deciphering Developmental Disorders Study, Eamonn G Sheridan, Frank J Kaiser, Gabriele Gillessen-Kaesbach, Georg C Korenke, Hadchouel, Haruta, Hibi, Hu, Ian M Carr, Kaartinen, Lachance, Lewerenz, Lisa Nalbach, Luo, Mallaret, Mulherkar, Mushtaq Ahmed, Nagase, Parry, Ronja Hollstein, Sakata, Sandeep Uppal, Schwarz, Slade, Song, Tang, Thomas Wieland, Tim M Strom, Torrino, Verity L Hartill, Yu, Zhang, Zhao   +45 more
core   +2 more sources

WWOX and metabolic regulation in normal and pathological conditions

Journal of Molecular Medicine, 2022
AbstractWW domain-containing oxidoreductase (WWOX) spans the common fragile site FRA16D. There is evidence that translocations and deletions affecting WWOX accompanied by loss of expression are frequent in many cancers and often correlate with a worse prognosis.
Izabela Baryła, Katarzyna Kośla, Andrzej K. Bednarek   +2 more
openaire   +2 more sources

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved

Frontiers in Oncology, 2018
It has become clear from multiple studies that WWOX (WW domain-containing oxidoreductase) operates as a “non-classical” tumor suppressor of significant relevance in cancer progression.
Tabish Hussain, Jaeho Lee, Martin C. Abba, Junjie Chen, C. Marcelo Aldaz   +4 more
doaj   +1 more source

Expression profile of CREB knockdown in myeloid leukemia cells. [PDF]

, 2008
BackgroundThe cAMP Response Element Binding Protein, CREB, is a transcription factor that regulates cell proliferation, differentiation, and survival in several model systems, including neuronal and hematopoietic cells.
Cheng, Jerry C, Judelson, Dejah, Nelson, Stanley F, Pellegrini, Matteo, Sakamoto, Kathleen M, Taylor, Julie, Voutila, Jon   +6 more
core   +2 more sources

Pleiotropic tumor suppressor functions of WWOX antagonize metastasis [PDF]

Signal Transduction and Targeted Therapy, 2020
AbstractTumor progression and metastasis are the major causes of death among cancer associated mortality. Metastatic cells acquire features of migration and invasion and usually undergo epithelia-mesenchymal transition (EMT). Acquirement of these various hallmarks rely on different cellular pathways, including TGF-β and Wnt signaling.
Victoria L. Seewaldt, Giovanni Nigita, Saleh Khawaled, Carlo M. Croce, Tamar Geiger, Sara Oster, Rami I. Aqeilan, Rami I. Aqeilan, Rosario Distefano, Yoav Smith, Abed Khalaileh, Sung-Suk Suh, Yong Peng   +12 more
openaire   +2 more sources

Copy number variants are produced in response to low‐dose ionizing radiation in cultured cells [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106089/1/em21840 ...
Arlt, Martin F., Birkeland, Shanda R., Glover, Thomas W., Rajendran, Sountharia, Wilson, Thomas E.   +4 more
core   +1 more source

Wwox Deletion in Mouse B Cells Leads to Genomic Instability, Neoplastic Transformation, and Monoclonal Gammopathies

Frontiers in Oncology, 2019
WWOX (WW domain containing oxidoreductase) expression loss is common in various cancers and characteristic of poor prognosis. Deletions, translocations, and loss of expression affecting the WWOX gene are a common feature of various B cell neoplasms such ...
Kevin M. McBride, Hyunsuk Kil, Yunxiang Mu, Joshua B. Plummer, Jaeho Lee, Maciej J. Zelazowski, Manu Sebastian, Martin C. Abba, C. Marcelo Aldaz   +8 more
doaj   +1 more source