Results 71 to 80 of about 6,450 (234)

Loss of Wwox Perturbs Neuronal Migration and Impairs Early Cortical Development

Frontiers in Neuroscience, 2020
Mutations in the WWOX gene cause a broad range of ultra-rare neurodevelopmental and brain degenerative disorders, associated with a high likelihood of premature death in animal models as well as in humans.
Michele Iacomino, Simona Baldassari, Yuki Tochigi, Katarzyna Kośla, Francesca Buffelli, Annalaura Torella, Annalaura Torella, Mariasavina Severino, Dario Paladini, Luana Mandarà, Antonella Riva, Marcello Scala, Marcello Scala, Ganna Balagura, Ganna Balagura, Andrea Accogli, Andrea Accogli, Vincenzo Nigro, Vincenzo Nigro, Carlo Minetti, Carlo Minetti, Ezio Fulcheri, Ezio Fulcheri, Federico Zara, Federico Zara, Andrzej K. Bednarek, Pasquale Striano, Pasquale Striano, Hiroetsu Suzuki, Vincenzo Salpietro, Vincenzo Salpietro, Vincenzo Salpietro   +31 more
doaj   +1 more source

Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1. [PDF]

, 2015
In tumor cells, two factors are abnormally increased that contribute to metastatic bone disease: Runx2, a transcription factor that promotes expression of metastasis related and osteolytic genes; and IL-11, a secreted osteolytic cytokine.
Afzal, Akech, Ali, Aqeilan, Bamba, Begley, Buijs, Calon, Campbell, Casimiro, D'Alonzo, Deng, Dutta, Eswaraka, Fradet, Furuya, Gordon, Hess, Huang, Ikushima, Iranikhah, Javed, Kamradt, Kang, Koeneman, Lay, Leong, Massague, Mathew, Matsumoto, Matsumura, McCoy, Mendoza-Villanueva, Morrissey, Necula, Ortiz, Padua, Pratap, Pratap, Pratap, Schroeder, Selvamurugan, Shen, Sottnik, Stein, Tang, Tang, Tohjima, van der Deen, Wan, Weilbaecher, Xiang, Yang, Yang, Yang, Young, Zaidi, Zhang, Zhang, Zurita   +59 more
core   +2 more sources

Wwox–Brca1 interaction: role in DNA repair pathway choice [PDF]

Oncogene, 2016
In this study, loss of expression of the fragile site-encoded Wwox protein was found to contribute to radiation and cisplatin resistance of cells, responses that could be associated with cancer recurrence and poor outcome. WWOX gene deletions occur in a variety of human cancer types, and reduced Wwox protein expression can be detected early during ...
Schrock, M. S., Batar, B., Lee, J., Druck, T., Ferguson, B., Cho, J. H., Akakpo, K., Hagrass, H., Heerema, N. A., Xia, F., Parvin, J. D., Aldaz, C. M., Huebner, K.   +12 more
openaire   +3 more sources

WW domain-containing oxidoreductase-related epileptic encephalopathy in Two Omani Children.

Journal of Biochemical and Clinical Genetics, 2023
Background: Autosomal recessive developmental and epileptic encephalopathy type 28 (DEE28) is a rare genetic disorder that affects children in the early months of life.
Moosa Al-Lawati, Zuha Al-Khaldi, Akbar Mohamed Chettali, Mariya Al-Hinai, Hiba Al-Mazrooey, Ali Al-Ajmi, Salma Al-Harasi, Nadia Al-Hashmi   +7 more
doaj   +1 more source

Phosphoenolpyruvate carboxykinase maintains glycolysis-driven growth in Drosophila tumors [PDF]

, 2017
Published online: 14 September 2017Tumors frequently fail to pass on all their chromosomes correctly during cell division, and this chromosomal instability (CIN) causes irregular aneuploidy and oxidative stress in cancer cells.
Gregory, S., Hussain, R., Khan, M., Saint, R., Shaukat, Z.   +4 more
core   +3 more sources

WWOX, large common fragile site genes, and cancer [PDF]

Experimental Biology and Medicine, 2015
WWOX is a gene that spans an extremely large chromosomal region. It is derived from within chromosomal band 16q23.2 which is a region with frequent deletions and other alterations in a variety of different cancers. This chromosomal band also contains the FRA16D common fragile site (CFS).
Ge, Gao, David I, Smith
openaire   +2 more sources

Altered neocortical oscillations and cellular excitability in an in vitro Wwox knockout mouse model of epileptic encephalopathy

Neurobiology of Disease, 2021
Summary: Loss of function mutations of the WW domain-containing oxidoreductase (WWOX) gene are associated with severe and fatal drug-resistant pediatric epileptic encephalopathy.
Vanessa L. Breton, Mark S. Aquilino, Srinivasarao Repudi, Afifa Saleem, Shanthini Mylvaganam, Sara Abu-Swai, Berj L. Bardakjian, Rami I. Aqeilan, Peter L. Carlen   +8 more
doaj   +1 more source

Novel principles of gamma-retroviral insertional transcription activation in murine leukemia virus-induced end-stage tumors [PDF]

, 2014
BACKGROUND: Insertional mutagenesis screens of retrovirus-induced mouse tumors have proven valuable in human cancer research and for understanding adverse effects of retroviral-based gene therapies.
Finn Pedersen, Irene Ruiz, Martin Sokol, Matthias Wabl   +3 more
core   +2 more sources

Antineoplastic Nature of WWOX in Glioblastoma Is Mainly a Consequence of Reduced Cell Viability and Invasion

Biology, 2023
Following the discovery of WWOX, research has moved in many directions, including the role of this putative tumor suppressor in the central nervous system and related diseases.
Żaneta Kałuzińska-Kołat, Katarzyna Kośla, Damian Kołat, Elżbieta Płuciennik, Andrzej K. Bednarek   +4 more
doaj   +1 more source

BcCluster: a bladder cancer database at the molecular level [PDF]

, 2016
Background: Bladder Cancer (BC) has two clearly distinct phenotypes. Non-muscle invasive BC has good prognosis and is treated with tumor resection and intravesical therapy whereas muscle invasive BC has poor prognosis and requires usually systemic ...
Bhat, Akshay, Jankowski, Vera, Mischak, Harald, Mokou, Marika, Vlahou, Antonia, Zoidakis, Jerome   +5 more
core   +3 more sources