Results 81 to 90 of about 6,450 (234)

The Role of DNA Methyltransferases in Urinary System Diseases

Cancer Innovation, Volume 4, Issue 6, December 2025.
Multiple signaling pathways mediated by DNMTs in the formation of renal fibrosis: (a) DNMTs suppress the expression of transcription factor KLF4 by mediating promoter hypermethylation, thereby promoting epithelial–mesenchymal transition and contributing to the development of renal fibrosis; (b) oxidative stress can upregulate the levels of DNMTs, which
Wei Dong, Shengbin Pei, Dacheng Zhu, Cheng Zeng, Yue Qiu, Yuxin Wu, Xinlu Jia, Siqi Zhang, Chao Li, Wenjuan Zhang, Wenbing Zhang, Zhihua Chen   +11 more
wiley   +1 more source

Association of Wwox with ErbB4 in Breast Cancer [PDF]

Cancer Research, 2007
Abstract WWOX, WW domain-containing oxidoreductase, is a tumor suppressor that is altered in many human cancers, including breast cancer. Wwox interacts with the ErbB4 receptor, reduces nuclear translocation of the cleaved intracellular domain of ErbB4, and inhibits its transactivation function mediated through Yes-associated protein.
Rami I, Aqeilan, Valentina, Donati, Eugenio, Gaudio, Milena S, Nicoloso, Maria, Sundvall, Anna, Korhonen, Johan, Lundin, Jorma, Isola, Marius, Sudol, Heikki, Joensuu, Carlo M, Croce, Klaus, Elenius   +11 more
openaire   +2 more sources

Novel homozygous mutation in the WWOX gene causes seizures and global developmental delay: Report and review

Translational Neuroscience, 2018
The WWOX gene has a WW domain containing oxidoreductase, which is located at the common fragile site FRA16D at chromosome 16q23. WWOX is a tumor suppressor gene that has been associated with several types of cancer such as hepatic, breast, lung, prostate,
Ehaideb Salleh N., Al-Bu Ali Majed J., Al-obaid Jaafer J., Aljassim Kareemah M., Alfadhel Majid   +4 more
doaj   +1 more source

Wwox Deletion in Mouse B Cells Leads to Genomic Instability, Neoplastic Transformation, and Monoclonal Gammopathies

Frontiers in Oncology, 2019
WWOX (WW domain containing oxidoreductase) expression loss is common in various cancers and characteristic of poor prognosis. Deletions, translocations, and loss of expression affecting the WWOX gene are a common feature of various B cell neoplasms such ...
Kevin M. McBride, Hyunsuk Kil, Yunxiang Mu, Joshua B. Plummer, Jaeho Lee, Maciej J. Zelazowski, Manu Sebastian, Martin C. Abba, C. Marcelo Aldaz   +8 more
doaj   +1 more source

Decoding the Cryptic Proteome Between Antigens and Novel Functional Proteins

European Journal of Immunology, Volume 55, Issue 12, December 2025.
Unannotated splicing and translation of non‐canonical open reading frames generate a diverse repertoire of cryptic proteins. Most are rapidly degraded, rendering them possible MHC‐I substrates. Yet, a subpopulation can adopt stable structures and impart advantageous functions.
Emma G. Bawden, Sebastian Amigorena, Yago A. Arribas   +2 more
wiley   +1 more source

Decreased WWOX expression promotes angiogenesis in osteosarcoma

Oncotarget, 2017
WWOX (WW domain-containing oxidoreductase) is known to be an important tumor suppressor in cancer. In this study, we used samples from 201 osteosarcoma patients to investigate the effects of WWOX on angiogenesis and invasion. WWOX levels were negatively correlated with RUNX2 and VEGF levels, but were not correlated with OPN levels.
Wen, Jia, Xu, Zongchao, Li, Jiazhen, Zhang, Yingqiang, Fan, Wenzhe, Wang, Yu, Lu, Mingjian, Li, Jiaping   +7 more
openaire   +3 more sources

Wwox and Ap2γ Expression Levels Predict Tamoxifen Response [PDF]

Clinical Cancer Research, 2007
Abstract Purpose: Assessment of expression levels of Wwox, Wwox-interacting proteins Ap2α, Ap2γ, and ErbB4, the Ap2γ transcriptional target protein Her2, and the possible Ap2α transcriptional target PrkaRIα, in breast cancers, to determine their roles in tamoxifen resistance.
Guler, Gulnur, Iliopoulos, Dimitrios, Guler, Nilufer, Himmetoglu, Cigdem, Hayran, Mutlu, Huebner, Kay   +5 more
openaire   +3 more sources

Supplementary Figure 4 from <i>WWOX</i> Gene Expression Abolishes Ovarian Cancer Tumorigenicity <i>In vivo</i> and Decreases Attachment to Fibronectin via Integrin α₃ [PDF]

, 2023
Charlie Gourley, Adam J.W. Paige, Karen J. Taylor, Carol V. Ward, Barbara Kuske, Jieqing Zhang, Mingjun Sun, Szymon Janczar, David J. Harrison, Morwenna Muir, John F. Smyth, Hani Gabra   +11 more
openalex   +2 more sources

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers [PDF]

, 2011
We describe methods with enhanced power and specificity to identify genes targeted by somatic copy-number alterations (SCNAs) that drive cancer growth. By separating SCNA profiles into underlying arm-level and focal alterations, we improve the estimation
A Baross, AB Olshen, AJ Bass, AJ Holland, B Nilsson, BA Weir, Barbara Hill, BM Bolstad, BS Taylor, C Greenman, C Li, C Li, Craig H Mermel, D Chiang, D Etemadmoghadam, D Hanahan, DY Chiang, E Pleasance, ED Pleasance, ES Venkatraman, F Sanchez-Garcia, G Schwarz, Gad Getz, GR Bignell, HS Dahlback, LM Merlo, M Guttman, M Metzker, Matthew L Meyerson, MR Stratton, Network CGAR, NT Leach, P Hupé, PA Northcott, PJ Stephens, PJ Stephens, R Beroukhim, R Beroukhim, R Firestein, R McLendon, Rameen Beroukhim, SA McCarroll, SJ Diskin, SP Shah, Steven E Schumacher, T Santarius, T Sjoblom, WM Lin, Y Benjamini   +48 more
core   +2 more sources

53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process [PDF]

, 2018
Chromosome missegregation acts as one of the driving forces for chromosome instability and cancer development. Here, we find that in human cancer cells, HeLa and U2OS, depletion of 53BP1 (p53-binding protein 1) exacerbates chromosome non-disjunction ...
A Biebricher, A Coquelle, A Janssen, A Moreno, A Xie, AM Casper, B McClintock, B Nera, B Wang, BA Weaver, BC Turner, C Baumann, C Escribano-Diaz, C Lengauer, C Lukas, D Jullien, F Ochs, H Wang, IM Ward, IM Ward, J Karlseder, J Maciejowski, J Maciejowski, JA Harrigan, JM Spence, JR Chapman, K Crasta, KL Chan, KL Chan, KL Chan, KL Chan, LC Funk, M Macville, M Schwartz, M Virgilio Di, M Zimmermann, MF Arlt, N Dimitrova, P Baumann, R Beroukhim, RA Burrell, RC Hengeveld, S Sengupta, S Ying, SF Bunting, SJ Xia, T Caspersson, T Davoli, T Taniguchi, TW Glover, V Naim, V Naim, V Tripathi, V Tripathi   +53 more
core   +2 more sources