Results 81 to 90 of about 6,282 (233)

Intermediate Conductance Calcium‐Dependent Potassium Channel (KCa3.1) Interacting Proteins Using Turboid‐Based Proximity Labeling Technology: Insights Into Interactome and Related Signaling Pathways in Pancreatic Tumors

Journal of Cellular Physiology, Volume 240, Issue 9, September 2025.
ABSTRACT KCa3.1 ion channel is a calcium‐activated potassium channel expressed in various tissues, showing dual localization to the plasma membrane and to mitochondria. This channel is highly expressed in numerous cancers and has been implicated in the regulation of proliferation and migration.
Veronica Carpanese, Soha Sadeghi, Luca Matteo Todesca, Ildikò Szabò, Vanessa Checchetto   +4 more
wiley   +1 more source

The WWOX Gene Influences Cellular Pathways in the Neuronal Differentiation of Human Neural Progenitor Cells

Frontiers in Cellular Neuroscience, 2019
The brain is the most functionally organized structure of all organs. It manages behavior, perception and higher cognitive functions. The WWOX gene is non-classical tumor suppressor gene, which has been shown to have an impact on proliferation, apoptosis
Katarzyna Kośla, Elżbieta Płuciennik, Ewa Styczeń-Binkowska, Magdalena Nowakowska, Magdalena Orzechowska, Andrzej K. Bednarek   +5 more
doaj   +1 more source

Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1. [PDF]

, 2015
In tumor cells, two factors are abnormally increased that contribute to metastatic bone disease: Runx2, a transcription factor that promotes expression of metastasis related and osteolytic genes; and IL-11, a secreted osteolytic cytokine.
Afzal, Akech, Ali, Aqeilan, Bamba, Begley, Buijs, Calon, Campbell, Casimiro, D'Alonzo, Deng, Dutta, Eswaraka, Fradet, Furuya, Gordon, Hess, Huang, Ikushima, Iranikhah, Javed, Kamradt, Kang, Koeneman, Lay, Leong, Massague, Mathew, Matsumoto, Matsumura, McCoy, Mendoza-Villanueva, Morrissey, Necula, Ortiz, Padua, Pratap, Pratap, Pratap, Schroeder, Selvamurugan, Shen, Sottnik, Stein, Tang, Tang, Tohjima, van der Deen, Wan, Weilbaecher, Xiang, Yang, Yang, Yang, Young, Zaidi, Zhang, Zhang, Zurita   +59 more
core   +2 more sources

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Antineoplastic Nature of WWOX in Glioblastoma Is Mainly a Consequence of Reduced Cell Viability and Invasion

Biology, 2023
Following the discovery of WWOX, research has moved in many directions, including the role of this putative tumor suppressor in the central nervous system and related diseases.
Żaneta Kałuzińska-Kołat, Katarzyna Kośla, Damian Kołat, Elżbieta Płuciennik, Andrzej K. Bednarek   +4 more
doaj   +1 more source

Sex‐stratified GWAS for Alzheimer’s Disease Reveals African Ancestry Risk variants in Men [PDF]

Alzheimers Dement
Abstract Background Several studies have indicated sex‐specific genetic risk for Alzheimer’s disease (AD), but these were centered on non‐Hispanic White individuals of European ancestry. We sought to identify sex‐specific genetic variants for AD in non‐Hispanic and Hispanic subjects of admixed African ancestry.
Belloy M, Reid D, Guen Y, Napolioni V, Greicius M.   +4 more
europepmc   +2 more sources

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers [PDF]

, 2011
We describe methods with enhanced power and specificity to identify genes targeted by somatic copy-number alterations (SCNAs) that drive cancer growth. By separating SCNA profiles into underlying arm-level and focal alterations, we improve the estimation
A Baross, AB Olshen, AJ Bass, AJ Holland, B Nilsson, BA Weir, Barbara Hill, BM Bolstad, BS Taylor, C Greenman, C Li, C Li, Craig H Mermel, D Chiang, D Etemadmoghadam, D Hanahan, DY Chiang, E Pleasance, ED Pleasance, ES Venkatraman, F Sanchez-Garcia, G Schwarz, Gad Getz, GR Bignell, HS Dahlback, LM Merlo, M Guttman, M Metzker, Matthew L Meyerson, MR Stratton, Network CGAR, NT Leach, P Hupé, PA Northcott, PJ Stephens, PJ Stephens, R Beroukhim, R Beroukhim, R Firestein, R McLendon, Rameen Beroukhim, SA McCarroll, SJ Diskin, SP Shah, Steven E Schumacher, T Santarius, T Sjoblom, WM Lin, Y Benjamini   +48 more
core   +2 more sources

FANCD2 facilitates replication through common fragile sites [PDF]

, 2016
Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the characteristics of CFSs that render them vulnerable to stress are mainly associated with replication, the cellular pathways that ...
Aguilera López, Andrés, García Rubio, María Luisa, Herrera Moyano, Emilia, Madireddy, Advaitha, Olson, Susan, Owen, Nichole   +5 more
core   +1 more source

Role of NTRK Fusion Genes in the Tumor Immune Microenvironment of HPV (+/−) Cervical Cancer

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT Cervical cancer, a prevalent gynecological malignancy, is primarily associated with human papillomavirus (HPV) infection. However, some cases display distinct molecular alterations beyond HPV, significantly impacting the tumor immune microenvironment (TIME) and posing therapeutic challenges.
Qiongying Wang, Chan Zhang, Shijia Liu, Wangshu Li, Wenjuan Wei, Aziz ur Rehman Aziz, Han Lu, Daqing Wang   +7 more
wiley   +1 more source

WWOX (WW domain containing oxidoreductase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2008
Review on WWOX (WW domain containing oxidoreductase), with data on DNA, on the protein encoded, and where the gene is implicated.
Druck, Teresa, Hagrass, Hoda, Huebner, Kay   +2 more
openaire   +2 more sources