Results 1 to 10 of about 2,696,015 (152)
Molecular Functions of WWOX Potentially Involved in Cancer Development
Cells, 2021 The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated
Karim Taouis +3 more
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WWOX Tumor Suppressor Gene in Breast Cancer, a Historical Perspective and Future Directions [PDF]
Frontiers in Oncology, 2018 The WWOX tumor suppressor gene is located at 16q23. 1–23.2, which covers the region of FRA16D—a common fragile sites. Deletions within the WWOX coding sequence are observed in up to 80% of breast cancer cases, which makes it one of the most common ...
Karolina Pospiech +2 more
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Loss of Wwox Perturbs Neuronal Migration and Impairs Early Cortical Development [PDF]
Frontiers in Neuroscience, 2020 Mutations in the WWOX gene cause a broad range of ultra-rare neurodevelopmental and brain degenerative disorders, associated with a high likelihood of premature death in animal models as well as in humans.
Michele Iacomino +31 more
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BMC Veterinary Research, 2020 Background The WW domain-containing oxidoreductase (WWOX) tumor suppressor gene is frequently lost in a variety of solid and hematopoietic malignancies in humans. Dysregulation of WWOX has been implicated as playing a key role in tumor cell survival, DNA
Rebecca Makii +7 more
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Acta Neuropathologica Communications, 2020 Human WWOX gene resides in the chromosomal common fragile site FRA16D and encodes a tumor suppressor WW domain-containing oxidoreductase. Loss-of-function mutations in both alleles of WWOX gene lead to autosomal recessive abnormalities in pediatric ...
Ya-Yun Cheng +14 more
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Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster. [PDF]
PLoS ONE, 2015 WWOX is a >1 Mb gene spanning FRA16D Common Chromosomal Fragile Site, a region of DNA instability in cancer. Consequently, altered WWOX levels have been observed in a wide variety of cancers. In vitro studies have identified a large number and variety of
Louise V O'Keefe +3 more
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Neurological Disorders Associated with WWOX Germline Mutations—A Comprehensive Overview
Cells, 2021 The transcriptional regulator WW domain-containing oxidoreductase (WWOX) is a key player in a number of cellular and biological processes including tumor suppression. Recent evidence has emerged associating WWOX with non-cancer disorders.
Ehud Banne +10 more
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Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches. [PDF]
PLoS ONE, 2012 Loss of WWOX expression has been reported in many different cancers including breast cancer. Elucidating the function of this gene in adult tissues has not been possible with full Wwox knockout models. Here we characterize the first conditional models of
Brent W Ferguson +6 more
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VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
BMC Biology, 2018 Background The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the pro-apoptotic protein p73α ...
Florian Bonin +18 more
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Neurobiology of Disease, 2021 Summary: Loss of function mutations of the WW domain-containing oxidoreductase (WWOX) gene are associated with severe and fatal drug-resistant pediatric epileptic encephalopathy.
Vanessa L. Breton +8 more
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