Loss of wwox expression in zebrafish embryos causes edema and alters Ca2+ dynamics [PDF]
PeerJ, 2015 We investigated the role of the WW domain-containing oxidoreductase (wwox) gene in the embryonic development of zebrafish, with particular emphasis on intracellular Ca2+ dynamics because Ca2+ is an important intracellular messenger.
Yusuke Tsuruwaka +2 more
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WWOX-Related Epileptic Encephalopathy (WOREE Syndrome): Clinical Case Study and Literature Review [PDF]
Current Issues in Molecular BiologyThe WW domain-containing oxidoreductase (WWOX) gene, well-known as a tumor suppressor, also has a crucial role as a transcription factor in the developing brain.
Annamaria Sapuppo +7 more
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WWOX-related epileptic encephalopathy caused by a novel mutation in the WWOX gene: a case report [PDF]
Frontiers in PediatricsBackgroundWWOX-related epileptic encephalopathy is an autosomal recessive disorder caused by mutations in the WW-containing oxidoreductase gene, characterized by the onset of refractory seizures in infants.
Dan Feng +5 more
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Developmental epileptic encephalopathy caused by homozygosity of a c.172+1G>C variant in the WWOX gene [PDF]
Molecular Genetics & Genomic MedicineBackground Variations in the WWOX gene have been identified as the leading cause of several central nervous system disorders. However, most previous reports have focused on the description of clinical phenotype, neglecting functional verification. Herein,
Yang You +4 more
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WWOX Induction Promotes Bcl-XL and Mcl-1 Degradation Through a Lysosomal Pathway upon Stress Responses [PDF]
CellsThe human WWOX gene resides on a common fragile site and is frequently deleted or altered during DNA replication. WWOX mutations are associated with various human diseases, including cancer, neurodegeneration, and developmental deficits.
Yu-Han Su +8 more
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Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas
Frontiers in Oncology, 2013 Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide and therapeutic drugs.
Ming-Fu eChiang +7 more
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WWOX-Related Neurodevelopmental Disorders: Models and Future Perspectives
Cells, 2021 The WW domain-containing oxidoreductase (WWOX) gene was originally discovered as a putative tumor suppressor spanning the common fragile site FRA16D, but as time has progressed the extent of its pleiotropic function has become apparent.
Daniel J. Steinberg, Rami I. Aqeilan
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The fragile site WWOX gene and the developing brain. [PDF]
Exp Biol Med (Maywood), 2015 Tabarki B, Al Mutairi F, Al Hashem A.
europepmc +2 more sources
Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player? [PDF]
J Neurosci ResAstrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Lange J +4 more
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WWOX Mutation as a Rare Cause of Neonatal-Infantile Parkinsonism Mimicking a Neurotransmitter Disorder: A Case Report. [PDF]
J Paediatr Child HealthJournal of Paediatrics and Child Health, Volume 62, Issue 7, Page 1273-1277, July 2026.
Serce Pehlevan O +3 more
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