Frontiers in Oncology, 2021 IntroductionThe presence of common fragile sites is associated with no-accidental chromosomal instability which occurs prior to carcinogenesis. The WWOX gene spans the second most active fragile site: FRA16D.
Damian Kołat +3 more
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Folate Interaction With Genetic Risk for Neural Tube Defects Among Infants in Bangladesh. [PDF]
Birth Defects ResABSTRACT Background Neural tube defects such as spina bifida (SB) are congenital anomalies associated with significant morbidity and mortality worldwide. Environmental factors, particularly folate, modify SB risk. Based on recurrence rates of SB within families, genetic risk also contributes to SB development.
Mondragon-Estrada E +13 more
europepmc +2 more sources
Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma [PDF]
British Journal of Cancer, 2004 The WWOX (WW-domain containing oxidoreductase) is a candidate tumour suppressor gene spanning the same chromosome region, 16q23, as the second most common fragile site (FS), FRA16D. Deletions detected by comparative genomic hybridisation (CGH) and loss of heterozygosity at microsatellite markers on chromosome 16q are common in many human cancers ...
C Marcelo Aldaz
exaly +3 more sources
WWOX gene is associated with HDL cholesterol and triglyceride levels [PDF]
BMC Medical Genetics, 2010 Background Altered lipid profile, and in particular low HDL and high triglyceride (TG) plasma levels, are within the major determinants of cardiovascular diseases.
Serrano-Ríos Manuel +6 more
doaj +3 more sources
WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis
European Journal of Cancer, 2010 WWOX is a bona fide tumour suppressor, with hypomorphic and knockout mouse models exhibiting increased tumour susceptibility. In ovarian cancer cells WWOX transfection abolishes tumourigenicity, suppresses tumour cell adhesion to extracellular matrix and induces apoptosis in non-adherent cells. One-third of ovarian tumours show loss of WWOX expression,
Manuela Zucknick +2 more
exaly +4 more sources
Prognostic Significance of WWOX/HIF1A Ratio in Cancer Subtypes: Insights into Metabolism, ECM, and EMT [PDF]
BiologyWWOX and HIF1α proteins are involved in cancer progression; their functions are closely related. WWOX binds HIF1α through its WW domains, sequestering it in the cytoplasm and inhibiting its transcriptional activity.
Izabela Baryła +3 more
doaj +2 more sources
WWOX tuning of oleic acid signaling orchestrates immunosuppressive macrophage polarization and sensitizes hepatocellular carcinoma to immunotherapy [PDF]
Journal for ImmunoTherapy of CancerBackground Immune checkpoint inhibitors (ICIs) are therapeutically effective for hepatocellular carcinoma (HCC) but are individually selective. This study examined the role of specific common fragile sites (CFSs) related gene in HCC immunotherapy.Methods
Min Xu +13 more
doaj +2 more sources
Genome-wide identification and functional validation of the WW domain containing oxidoreductase gene associated with sleep duration [PDF]
Scientific ReportsIndividual differences in sleep duration have been reported, and genetic components of sleep duration have been identified showing various heritability.
Soriul Kim +8 more
doaj +2 more sources
Case report: Adult patient with WWOX developmental and epileptic encephalopathy: 40 years of observation [PDF]
Frontiers in GeneticsWWOX developmental and epileptic encephalopathy is characterised by drug-resistant epilepsy with onset within the first year of life and severe psychomotor developmental delay.
Anna Teplyshova +3 more
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WWOX, A NEW POTENTIAL TUMOR SUPPRESSOR GENE [PDF]
Biomedical Papers, 2007 WWOX (WW domain-containing oxidoreductase) gene, located on chromosome 16q 23.3-24.1 in the region recognized as the common fragile site FRA16D is considered to be a tumor suppressor gene involved in various cancers: breast, ovarian, prostate, esophageal, lung, pancreatic, gastric and hepatic.
Renata, Hezova +2 more
openaire +2 more sources